Welcome to the Department of Biochemistry

MOLECULAR BIOLOGY, CELL BIOLOGY, DISEASE MECHANISMS

New Research Discoveries…Beige Adipocyte Differentiation

GprotCongratulations to the Farmer, Layne, and Smith laboratories for their recent publication in Cell investigating the mechanisms of beige adipocyte differentiation. Meghan McDonald and Chendi Li from the Farmer lab are co-first authors. This study found that BMPs induce brown adipogenesis from mesenchymal stem cells by inhibiting ROCK activity. Furthermore this study found that loss of the SRF cofactor MRTFA promoted browning and resistance to diet induced obesity. For more information on their current research please visit: Farmer lab. Layne lab.

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Spotlight on…Dr. Dafne Cardamone

Congratulations to Dr. Dafne Cardamone for her recent promotion to the rank of Instructor. Dr. Cardamone joined Dr. Perissi’s lab and the Biochemistry Department in 2011. Dafne received a PhD in Complex Systems in Molecular Biology from the University of Torino (Italy) and previously worked as a postdoctoral fellow in the Rosenfeld lab at UCSD. In Dr. Perissi’s lab, Dafne is investigating a small transcriptional cofactor, G Protein Suppressor 2 (GPS2) in adipocytes and immune cells. Her studies have revealed interesting insights into the role of GPS2 in regulating inflammation and lipid metabolism via modulating ubiquitin signaling (Cardamone et al, Mol Cell 2012; Cardamone et al, Cell Reports 2014). For past Spotlights:Archives

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