New Research Discoveries…Crb3 and Airway Cell Differentiation
Congratulations to the Varelas Lab for their recent publication in Developmental Cell investigating the relationship between cell polarity and cell fate in the lung. Aleks Szymaniak, a PhD candidate in the Varelas lab, found that the apical polarity determinant Crb3 is an essential regulator of airway cell maturation and that Crb3 scaffolds Hippo pathway components at the apical domain of epithelial cells to restrict the nuclear activity of the transcriptional regulator Yap, and showed that loss of Crb3 results in aberrant airway cell maturation. This study provides a novel mechanism for how tissue architecture integrates with cell fate during organ development. For more information on their research please visit: Varelas lab.
Spotlight on…Dr. Dafne Cardamone
Congratulations to Dr. Dafne Cardamone for her recent promotion to the rank of Instructor. Dr. Cardamone joined Dr. Perissi’s lab and the Biochemistry Department in 2011. Dafne received a PhD in Complex Systems in Molecular Biology from the University of Torino (Italy) and previously worked as a postdoctoral fellow in the Rosenfeld lab at UCSD. In Dr. Perissi’s lab, Dafne is investigating a small transcriptional cofactor, G Protein Suppressor 2 (GPS2) in adipocytes and immune cells. Her studies have revealed interesting insights into the role of GPS2 in regulating inflammation and lipid metabolism via modulating ubiquitin signaling (Cardamone et al, Mol Cell 2012; Cardamone et al, Cell Reports 2014).
For past Spotlights:Archives