Ella Zeldich

Research Assistant Professor Down Syndrome, Myelin abnormalities, cellular IPS-derived models

  • Title Research Assistant Professor

    Down Syndrome, Myelin abnormalities, cellular IPS-derived models
  • Office L-810
  • Phone 617-358-0811

Dr. Zeldich obtained her Ph.D. degree at Department of Physiology and Pharmacology in Tel Aviv University, Israel. In 2011, Dr. Zeldich joined Dr. Carmela Abraham’s lab, Department of Biochemistry at BUSM as a postdoctoral associate. Her research was focused on characterization of the molecular mechanisms leading to normal brain aging and the pathological processes associated with Alzheimer’s disease (AD) and multiple sclerosis (MS). Specifically, she explored the role of anti-aging Klotho protein in the brain as a target for prevention and treatment of neurodegenerative and demyelinating disorders such as AD, MS and Amyotrophic Lateral Sclerosis (ALS) utilizing principles of basic and translational research.
Dr. Zeldich joined the Department of Anatomy and Neurobiology in December 2018 as a member of Dr. Tarik Haydar’s group. Her current research is focused on elucidating molecular and cellular mechanisms underlying the abnormal myelination associated with Down Syndrome and understanding the source of the defective communication between the glial and neuronal cells using iPS cells. Dr. Zeldich is interested in generating functioning iPS-derived oligodendrocytes to further assess the myelination machinery in in vitro and in in vivo models. She is also actively collaborating on studying the diversity and priming of neuronal progenitors in the embryonic cortex during brain development.
Her future research agenda is focused on studying myelination-related abnormalities and heterogeneity of neuronal stem cells in human brain organoids.

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