{"id":871,"date":"2013-09-06T10:02:47","date_gmt":"2013-09-06T14:02:47","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/wci-training-programs\/?page_id=871"},"modified":"2013-09-06T17:34:45","modified_gmt":"2013-09-06T21:34:45","slug":"christopher-james-mcknight-ph-d","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/wci-training-programs\/mentors\/christopher-james-mcknight-ph-d\/","title":{"rendered":"Christopher James McKnight, Ph.D."},"content":{"rendered":"<h3>Associate Professor of Physiology and Biophysics<\/h3>\n<p><img loading=\"lazy\" src=\"\/wci-training-programs\/files\/2013\/04\/Jamie-McKnight-regalia.jpg\" alt=\"Jamie McKnight regalia\" title=\"Jamie McKnight regalia\" class=\"alignright size-full wp-image-872\" height=\"276\" width=\"212\" \/><\/p>\n<p>Direct Contact: <a href=\"mailto:cjmck@bu.edu\">cjmck@bu.edu<\/a><\/p>\n<p><a href=\"http:\/\/biophysics.bumc.bu.edu\/faculty\/mcknight\">Lab Website<\/a><\/p>\n<p><a href=\"\/wci-training-programs\/files\/2013\/04\/CJMcKnight-Publications-LINKED.pdf\">Publications<\/a> <a href=\"\/wci-training-programs\/files\/2013\/04\/CJMcKnight-Positions-and-Honors.pdf\">Positions and Honors<\/a><\/p>\n<p>My research focuses on the structural aspects of protein folding and the assembly of protein lipidcomplexes.\u00a0 A wide range of approaches is used including molecular biology, electron microscopy, X-Ray crystallography, circular dichroism, thermodynamic measurements and others.\u00a0 A key technology used is heteronuclear NMR.\u00a0 Our main focus is the structural characterization of apolipoprotein B and its role in the assembly and secretion of very low density lipoprotein, the precursor of low density lipoprotein (LDL, the &#8220;bad cholesterol&#8221;).\u00a0 Also of interest are the structure and folding &#8220;villin-type&#8221; headpiece domains and their interactions with actin and other regulatory proteins.\u00a0 The laboratory also applies its structural biology approach to collaborative projects.<\/p>\n<p>&nbsp;<\/p>\n<p>I direct the Boston University School of Medicine Core Facility for Structural NMR.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Associate Professor of Physiology and Biophysics Direct Contact: cjmck@bu.edu Lab Website Publications Positions and Honors My research focuses on the structural aspects of protein folding and the assembly of protein lipidcomplexes.\u00a0 A wide range of approaches is used including molecular biology, electron microscopy, X-Ray crystallography, circular dichroism, thermodynamic measurements and others.\u00a0 A key technology used [&hellip;]<\/p>\n","protected":false},"author":6933,"featured_media":0,"parent":843,"menu_order":21,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/wci-training-programs\/wp-json\/wp\/v2\/pages\/871"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/wci-training-programs\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/wci-training-programs\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/wci-training-programs\/wp-json\/wp\/v2\/users\/6933"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/wci-training-programs\/wp-json\/wp\/v2\/comments?post=871"}],"version-history":[{"count":8,"href":"https:\/\/www.bumc.bu.edu\/wci-training-programs\/wp-json\/wp\/v2\/pages\/871\/revisions"}],"predecessor-version":[{"id":1252,"href":"https:\/\/www.bumc.bu.edu\/wci-training-programs\/wp-json\/wp\/v2\/pages\/871\/revisions\/1252"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/wci-training-programs\/wp-json\/wp\/v2\/pages\/843"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/wci-training-programs\/wp-json\/wp\/v2\/media?parent=871"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}