{"id":55,"date":"2010-04-24T07:45:39","date_gmt":"2010-04-24T11:45:39","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/ravidlab\/?page_id=55"},"modified":"2025-10-27T09:45:22","modified_gmt":"2025-10-27T13:45:22","slug":"publications","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/ravidlab\/publications\/","title":{"rendered":""},"content":{"rendered":"

Representative Recent Publications:\"Screen<\/a><\/h3>\n

An updated (every 3-6 months) list of publications can be found in:
<\/strong> https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Ravid+K&sort=date<\/a>
<\/span><\/span><\/p>\n

http:\/\/profiles.bu.edu\/Katya.Ravid\u00a0<\/a>
<\/span><\/span>Highlights of Ravid\u2019s lab contribution to the field of polyploidy in context of platelets and vascular function, podcasted in a\u00a0<\/span>Science editorial interview article\u00a0<\/span><\/span><\/i><\/span>(Science vol 343 14, Feb 2014, page 725<\/a>)<\/span><\/span><\/i><\/span><\/p>\n

Press Releases:<\/strong>
<\/span>Dr. Ravid’s lab mechanistic studies lead to clinical studies with promising results:

https:\/\/www.bumc.bu.edu\/camed\/news-events\/articles\/2025\/high-protein-or-trp-diet-increases-the-risk-of-cancer-associated-venous-thromboembolism\/<\/a>

Collaboration Between BU Clinicians, Basic Scientists and Engineers Can Lead to New Drugs to Fight Disease<\/a><\/strong><\/p>\n

An AHA-funded center led by Dr. Ravid to \u00a0examine the link between cancer (including of hematopoietic origin) and cardiovascular diseases, with a special focus on understanding and preventing health disparities. Please see:\u00a0
<\/span><\/b>Why Are Black Cancer Patients at Higher Risk for Blood Clots?<\/a>
<\/span><\/b><\/p>\n

New drugs for myelofibrosis as basis for a clinical trial <\/b>(clinical trial number: NCT04676529)
<\/strong><\/span><\/em>To read more see the featured article on the BU Chobanian & Avedisian School of Medicine page<\/a> and also referenced in a March 22, 2021, posting by medicalxpress.com\/news
<\/a>New possible treatment approach to primary myelofibrosis<\/strong>
Researchers Attempt New Treatment Approach for Blood Cancer
<\/a><\/span>Discovering new Paths to Thrombosis published in<\/strong> Science Translational Medicine
<\/strong>Understanding a Therapeutic \u201cParadox\u201d for Treating Thrombo-Vascular Complications in Kidney Disease<\/a>\"TranslationalScienceCover2017\"<\/a><\/p>\n

Discovery of a new pathway involved in control of thrombosis
Researchers Discover Key Pathway Involved in Blood Vessel Occlusion
<\/a>Key pathway involved in blood vessel occlusion discovered
<\/a>Adenosine signaling promotes hematopoietic stem and progenitor cell emergence
<\/a><\/a>Study identifies Adenosine Receptor’s role in regulating high fat diet-induced obesity and type 2 diabetes
<\/a><\/a><\/a>http:\/\/www.news-medical.net\/news\/20111213\/Scientists-identify-A2bAR-as-possible-new-therapeutic-target-against-atherosclerosis.aspx
<\/a>http:\/\/medicalxpress.com\/news\/2011-12-agent-responsible-early-stages-atherosclerosis.html
<\/a>http:\/\/www.sciencedaily.com\/releases\/2011\/06\/110623141643.htm<\/a><\/p>\n

\"Blood_cover_image\"<\/a>
Blood Cover, Volume 116, Number 12, Sept 2010.<\/figcaption><\/figure>\n

Representative Papers & Reviews:\u00a0<\/span><\/h3>\n

Dietary tryptophan augments cancer-associated venous thrombogenicity mitigated by indoleamine 2,3-dioxygenase 1 inhibition.<\/a> <\/span>Lotfollahzadeh S, Jose A, Yang X, Bathla T, Lazowski A, Hoekstra I, Sethuraman K, Potluri S, Dulberger KN, La J, Fillmore NR, Piqueras MDC, Lee N, Cabral H,\u00a0Ravid K<\/b>, Chitalia VC.Blood Adv. 2025 Oct 14;9(19):4910-4923. doi: 10.1182\/bloodadvances.2025017079.PMID:\u00a040668615\u00a0Free PMC article.<\/b><\/span>\u00a0<\/span><\/p>\n

Tryptophan metabolism reprogramming contributes to the prothrombotic milieu in mice and humans infected with SARS-CoV-2.<\/a> <\/span>Subramaniam S, Napoleon MA, Lotfollahzadeh S, Kamal MH, Kurniawan H, Elsadawi M, Kenney D, Douam F, Bosmann M, Whelan S, Cabral H, Burks EJ, Zhao G, Kolachalama V,\u00a0Ravid K<\/b>, Chitalia V.bioRxiv [Preprint]. 2025 Jan 30:2025.01.17.633602. doi: 10.1101\/2025.01.17.633602.PMID:\u00a039896681\u00a0<\/span><\/p>\n

Epidemiology of Cancer-Associated Venous Thromboembolism in Patients With Solid and Hematologic Neoplasms in the Veterans Affairs Health Care System<\/a>. Martens KL, Li A, La J, May SB, Swinnerton KN, Tosi H, Elbers DC, Do NV, Brophy MT, Gaziano JM, Lotfollahzadeh S, Chitalia V, Ravid K<\/strong>, Fillmore NR. JAMA Netw Open. 2023 Jun 1;6(6):e2317945. doi: 10.1001\/jamanetworkopen.2023.17945. PMID: 37306999; PMCID: PMC10261992.<\/span><\/p>\n

Characterization of Glycoproteoforms of Integrins \u03b12 and \u03b21 in Megakaryocytes in the Occurrence of JAK2V617F Mutation-Induced Primary Myelofibrosis<\/a>. Gaye MM, Ward CM, Piasecki AJ, Stahl VL, Karagianni A, Costello CE, Ravid K<\/strong>. Mol Cell Proteomics. 2022 Apr;21(4):100213. doi: 10.1016\/j.mcpro.2022.100213. Epub 2022 Feb 17. PMID: 35182768; PMCID: PMC8968581.<\/span><\/p>\n

Indoleamine 2,3-dioxygenase-1, a Novel Therapeutic Target for Post-Vascular Injury Thrombosis in CKD.<\/a> Walker JA, Richards S, Whelan SA, Yoo SB, Russell TL, Arinze N, Lotfollahzadeh S, Napoleon MA, Belghasem M, Lee N, Dember LM, Ravid K<\/strong>, Chitalia VC. J Am Soc Nephrol. 2021 Nov;32(11):2834-2850. doi: 10.1681\/ASN.2020091310. PMID: 34716244; PMCID: PMC8806102.<\/span><\/p>\n

Adhesion to fibronectin via \u03b15\u03b21 integrin supports expansion of the megakaryocyte lineage in primary myelofibrosis.<\/a> Matsuura S, Thompson CR, Ng SK, Ward CM, Karagianni A, Mazzeo C, Malara A, Balduini A, Ravid K<\/strong>. Blood. 2020 Jun 18;135(25):2286-2291. PMID: 32294178; PMCID: PMC7316217.<\/span><\/p>\n

Matrix Mechanosensation in the Erythroid and Megakaryocytic Lineages.<\/a> Ward CM, Ravid K<\/strong>. Cells. 2020 Apr 06; 9(4).<\/span>View Related Profiles.\u00a0PMID:\u00a0<\/span>32268541<\/span><\/a><\/p>\n

Emerging Factors Implicated in Fibrotic Organ-Associated Thrombosis: The Case of Two Organs.<\/a> Leiva O, Bekendam RH, Garcia BD, Thompson C, Cantor A, Chitalia V, Ravid K<\/strong>. TH Open. 2019 Apr; 3(2):e165-e170.<\/span>View Related Profiles.\u00a0<\/span>PMID:\u00a0<\/span><\/span>31259299<\/span><\/a><\/a><\/span><\/p>\n

The role of extracellular matrix stiffness in megakaryocyte development and function.<\/a>\u00a0<\/span>Leiva O, Leon C, Kak Ng S, Mangin P, Gachet C,\u00a0Ravid K<\/b>.\u00a0<\/span>Am J Hematol. 2018 Mar;93(3):430-441. doi: 10.1002\/ajh.25008. Epub 2018 Jan 12. Review.
\n<\/span><\/p>\n

Biology of Platelet Purinergic Receptors and Implications for Platelet Heterogeneity<\/a>. Koupenova M, Ravid K<\/strong>.
\nFront Pharmacol. 2018 Jan 30;9:37. doi: 10.3389\/fphar.2018.00037. eCollection 2018. Review.<\/p>\n

The role of the extracellular matrix in primary myelofibrosis.<\/a> Leiva O, Ng SK, Chitalia S, Balduini A, Matsuura S, Ravid K<\/strong>. Blood Cancer J. 2017 Feb 3;7(2):e525. doi: 10.1038\/bcj.2017.6. Review.<\/p>\n

The Many Faces of the A2b Adenosine Receptor in Cardiovascular and Metabolic Diseases.<\/a> Eisenstein A, Patterson S, Ravid K<\/strong>. J Cell Physiol. 2015 Dec;230(12)2891-7. doi: 10.1002\/jcp.25043. Review. <\/a><\/p>\n

G protein-coupled receptors and adipogenesis: a focus on adenosine receptors.<\/a> Eisenstein A, Ravid K<\/strong>. J Cell Physiol. 2014 Apr;229(4):414-21. doi: 10.1002\/jcp.24473. Review. <\/a><\/p>\n

Regulation of atherosclerosis and associated risk factors by adenosine and adenosine receptors.<\/a> Koupenova M, Johnston-Cox H, Ravid K<\/b>. Curr Atheroscler Rep. 2012 Oct;14(5):460-8. doi: 10.1007\/s11883-012-0263-y.<\/p>\n

A2 adenosine receptors and vascular pathologies. <\/a> Johnston-Cox HA, Koupenova M, Ravid K<\/b>. Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):870-8. doi: 10.1161\/ATVBAHA.112.246181. Review. <\/a><\/p>\n

Megakaryocyte pathology and bone marrow fibrosis: the lysyl oxidase connection. <\/a> Papadantonakis N, Matsuura S, Ravid K<\/b>. Blood. 2012 Aug 30;120(9):1774-81. doi: 10.1182\/blood-2012-02-402594. Epub 2012 Jul 5. Review.<\/p>\n

Oxidases and reactive oxygen species during hematopoiesis: A focus on megakaryocytes<\/a>. Eliades A, Matsuura S, Ravid K<\/strong>. J Cell Physiol. 2012 Fab 13. doi: 10.1002\/jcp.24071. <\/a><\/p>\n

Adenosine and Blood Platelets.<\/a> Johnston-Cox H and Ravid K<\/strong>. Purinergic Signalling. 2011 Sept;7(3):357-65. <\/a><\/p>\n

P<\/a>hysiological Implications of Adenosine Receptor-Mediated Platelet Aggregation.<\/a> Johnston-Cox H, Yang D, Ravid K<\/strong>. J Cell Physiol. 2011 Jan;226(1):46-51. <\/a><\/p>\n

Mechanisms of induction of adenosine receptor genes and its functional<\/a> significance.<\/a> St Hilaire C, Carroll SH, Chen H, Ravid K<\/strong>. J Cell Physiol. 2009 Jan;218(1):35-44. Review. PMID: 18767039 [PubMed – indexed for MEDLINE] <\/a><\/p>\n

Vascular smooth muscle cell polyploidy: an adaptive or maladaptive response?<\/a> McCrann DJ, Nguyen HG, Jones MR, Ravid K<\/strong>. J Cell Physiol. 2008 Jun;215(3):588-92. Review. PMID: 18181174 [PubMed – indexed for MEDLINE] <\/a><\/p>\n

Tetraploidy\/aneuploidy and stem cells in cancer promotion: The role of<\/a> chromosome passenger proteins.<\/a> Nguyen HG, Ravid K<\/strong>. J Cell Physiol. 2006 Jul;208(1):12-22. Review. PMID: 16331679 [PubMed – indexed for MEDLINE] <\/a><\/p>\n

Animal models for the study of adenosine receptor function.<\/a> Yaar R, Jones MR, Chen JF, Ravid K<\/strong>. J Cell Physiol. 2005 Jan;202(1):9-20. Review. PMID: 15389588 [PubMed – indexed for MEDLINE] <\/a><\/p>\n

Role of apoptotic processes in platelet biogenesis.<\/a> Kaluzhny Y, Ravid K<\/strong>. Acta Haematol. 2004;111(1-2):67-77. Review. PMID: 14646346 [PubMed – indexed for MEDLINE] <\/a><\/p>\n

Roads to polyploidy: the megakaryocyte example.<\/a> Ravid K<\/strong>, Lu J, Zimmet JM, Jones MR. J Cell Physiol. 2002 Jan;190(1):7-20. Review. PMID: 11807806 [PubMed – indexed for MEDLINE] <\/a><\/p>\n

Polyploidy: occurrence in nature, mechanisms, and significance for the<\/a> megakaryocyte-platelet system.<\/a> Zimmet J, Ravid K<\/strong>. Exp Hematol. 2000 Jan;28(1):3-16. Review. PMID: 10658672 [PubMed – indexed for MEDLINE]<\/p>\n

Books:<\/h3>\n

\"dnatransferbook.kravid\"<\/a>
\nhttp:\/\/www.wiley-vch.de\/publish\/en\/books\/bySubjectLS00\/bySubSubjectLS30\/0-47<\/a>1-16572-7\/?sID=0f8tr9bpr0j38tpt8tn3tb9q84<\/a> <\/a>
\n\"tf.kravid.book\"<\/a>
\nhttp:\/\/www.boomerangbooks.com.au\/Transcription-Factors\/K-Ravid\/book_97804713<\/a>50545.htm<\/a>
\n<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Representative Recent Publications: An updated (every 3-6 months) list of publications can be found in: https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Ravid+K&sort=date http:\/\/profiles.bu.edu\/Katya.Ravid\u00a0 Highlights of Ravid\u2019s lab contribution to the field of polyploidy in context of platelets and vascular function, podcasted in a\u00a0Science editorial interview article\u00a0(Science vol 343 14, Feb 2014, page 725) Press Releases: Dr. Ravid’s lab mechanistic studies lead […]<\/p>\n","protected":false},"author":1249,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/ravidlab\/wp-json\/wp\/v2\/pages\/55"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/ravidlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/ravidlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ravidlab\/wp-json\/wp\/v2\/users\/1249"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ravidlab\/wp-json\/wp\/v2\/comments?post=55"}],"version-history":[{"count":52,"href":"https:\/\/www.bumc.bu.edu\/ravidlab\/wp-json\/wp\/v2\/pages\/55\/revisions"}],"predecessor-version":[{"id":1250,"href":"https:\/\/www.bumc.bu.edu\/ravidlab\/wp-json\/wp\/v2\/pages\/55\/revisions\/1250"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/ravidlab\/wp-json\/wp\/v2\/media?parent=55"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}