{"id":2797,"date":"2020-11-03T11:18:43","date_gmt":"2020-11-03T16:18:43","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/pulmonarycenter\/?p=2797"},"modified":"2020-11-03T17:09:03","modified_gmt":"2020-11-03T22:09:03","slug":"past-infections-with-other-coronaviruses-influence-covid-19","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/pulmonarycenter\/2020\/11\/03\/past-infections-with-other-coronaviruses-influence-covid-19\/","title":{"rendered":"Past infections with other coronaviruses influence COVID-19"},"content":{"rendered":"<p><img loading=\"lazy\" src=\"\/pulmonary\/files\/2020\/11\/spotlight-pic-2-1024x658.png\" alt=\"\" width=\"1024\" height=\"658\" class=\"aligncenter wp-image-4542 size-large\" \/>Endemic coronaviruses have been causing human infections for many years, long before the recent emergence of SARS-CoV-2 which causes COVID-19. Jay Mizgerd and Manish Sagar (from the Section of Infectious Diseases) hypothesized that infections with endemic coronavirus, which are molecularly similar to SARS-CoV-2, might elicit cross-reactive immunity that influences what happens during a SARS-CoV-2 infection. They tested this hypothesis using medical records from the Boston Medical Center. They found that those who had been <img loading=\"lazy\" src=\"\/pulmonarycenter\/files\/2020\/11\/spotlight-pic-1-150x150.png\" alt=\"\" width=\"150\" height=\"150\" class=\"size-thumbnail wp-image-2798 alignleft\" \/>diagnosed within the prior 5 years with an endemic coronavirus infection fared better during COVID-19, compared to others who were similarly tested in the same time-frame but did not have endemic coronaviruses diagnosed. The rates of SARS-CoV-2 infection were similar between the groups, as were the rates of SARS-CoV-2 hospitalization. However, those with prior coronavirus <img loading=\"lazy\" src=\"\/pulmonarycenter\/files\/2020\/11\/spotlight-pic-3-150x150.png\" alt=\"\" width=\"150\" height=\"150\" class=\"size-thumbnail wp-image-2800 alignleft\" srcset=\"https:\/\/www.bumc.bu.edu\/pulmonarycenter\/files\/2020\/11\/spotlight-pic-3-150x150.png 150w, https:\/\/www.bumc.bu.edu\/pulmonarycenter\/files\/2020\/11\/spotlight-pic-3-300x300.png 300w, https:\/\/www.bumc.bu.edu\/pulmonarycenter\/files\/2020\/11\/spotlight-pic-3-100x100.png 100w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/>diagnoses were less likely to need ICU admission and were less likely to die. These findings suggest that immunity against endemic coronaviruses may cross-react with SARS-CoV-2 and help<br \/>\nprevent serious infections in the lung. The study is published in the <a href=\"https:\/\/www.jci.org\/articles\/view\/143380\" target=\"_blank\" rel=\"noopener noreferrer\">Journal of Clinical Investigation<\/a>.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Endemic coronaviruses have been causing human infections for many years, long before the recent emergence of SARS-CoV-2 which causes COVID-19. Jay Mizgerd and Manish Sagar (from the Section of Infectious Diseases) hypothesized that infections with endemic coronavirus, which are molecularly similar to SARS-CoV-2, might elicit cross-reactive immunity that influences what happens during a SARS-CoV-2 infection. [&hellip;]<\/p>\n","protected":false},"author":16527,"featured_media":2799,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[4141],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonarycenter\/wp-json\/wp\/v2\/posts\/2797"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonarycenter\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonarycenter\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonarycenter\/wp-json\/wp\/v2\/users\/16527"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonarycenter\/wp-json\/wp\/v2\/comments?post=2797"}],"version-history":[{"count":8,"href":"https:\/\/www.bumc.bu.edu\/pulmonarycenter\/wp-json\/wp\/v2\/posts\/2797\/revisions"}],"predecessor-version":[{"id":2809,"href":"https:\/\/www.bumc.bu.edu\/pulmonarycenter\/wp-json\/wp\/v2\/posts\/2797\/revisions\/2809"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonarycenter\/wp-json\/wp\/v2\/media\/2799"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonarycenter\/wp-json\/wp\/v2\/media?parent=2797"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonarycenter\/wp-json\/wp\/v2\/categories?post=2797"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonarycenter\/wp-json\/wp\/v2\/tags?post=2797"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}