{"id":6823,"date":"2024-02-23T12:48:40","date_gmt":"2024-02-23T16:48:40","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/pulmonary\/?p=6823"},"modified":"2024-08-08T12:49:34","modified_gmt":"2024-08-08T16:49:34","slug":"new-r01-fibrin-in-the-infected-lung","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/pulmonary\/2024\/02\/23\/new-r01-fibrin-in-the-infected-lung\/","title":{"rendered":"New R01: Fibrin in the Infected Lung"},"content":{"rendered":"<p>We are pleased to share that Joseph P. Mizgerd, ScD, the Jerome S. Brody, MD, Professor of Pulmonary Medicine and Director of the Pulmonary Center, has been awarded a four-year, $2.9 million RO1 grant from the NIH\u2019s National Heart, Lung, and Blood Institute for his research \u201cFibrin in the Infected Lung.\u201d Co-investigators on the grant include Drs. Katrina Traber and Nicholas Crossland from BU, and Dr. Thomas Beach from Banner Sun Health (Sun City, AZ).<\/p>\n<p>The study aims to address the challenge of identifying pneumonia subtypes that respond to host-directed therapies. Some pneumonia cases exhibit abundant fibrin in the airspaces, while others do not. \u201cBecause fibrin can be pro-inflammatory and neutrophils (a type of white blood cell) can enhance fibrin accumulation, we propose the central hypothesis that fibrin and neutrophils in the airspaces form a positive feedback loop that causes damage in a subset of pneumonias,\u201d explains Mizgerd.<\/p>\n<div class=\"flex flex-grow flex-col max-w-full\">\n<div data-message-author-role=\"assistant\" data-message-id=\"4637d514-0f00-43c7-8f18-463892ef26cf\" class=\"min-h-[20px] text-message flex flex-col items-start gap-3 whitespace-pre-wrap break-words [.text-message+&amp;]:mt-5 overflow-x-auto\">\n<div class=\"markdown prose w-full break-words dark:prose-invert dark\">\n<p>Dr. Mizgerd&#8217;s recent work highlights changes in lung-localized immune systems post-recovery, including resident memory lymphocytes and trained innate immunity. This new study aims to clarify high fibrin accumulation mechanisms in infected lungs, informing potential efficacy of host-directed therapies such as thrombolytics or anticoagulants.<\/p>\n<figure id=\"attachment_4716\" aria-describedby=\"caption-attachment-4716\" style=\"width: 871px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" src=\"\/pulmonarycenter\/files\/2024\/02\/February-Mizgerd-RO1.png\" alt=\"\" class=\"wp-image-4716 size-full\" width=\"861\" height=\"532\" \/><figcaption id=\"caption-attachment-4716\" class=\"wp-caption-text\">A and B are each from humans who died with pneumonia. The lungs from the subject in A show no polymerized fibrin, whereas the lungs in B show abundant polymerized fibrin.<\/figcaption><\/figure>\n<p>Read more here: <a href=\"https:\/\/www.bumc.bu.edu\/camed\/2024\/02\/15\/joseph-p-mizgerd-scd-awarded-2-9-million-to-better-understand-pneumonia\/\">https:\/\/www.bumc.bu.edu\/camed\/2024\/02\/15\/joseph-p-mizgerd-scd-awarded-2-9-million-to-better-understand-pneumonia\/ <\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>We are pleased to share that Joseph P. Mizgerd, ScD, the Jerome S. Brody, MD, Professor of Pulmonary Medicine and Director of the Pulmonary Center, has been awarded a four-year, $2.9 million RO1 grant from the NIH\u2019s National Heart, Lung, and Blood Institute for his research \u201cFibrin in the Infected Lung.\u201d Co-investigators on the grant [&hellip;]<\/p>\n","protected":false},"author":22552,"featured_media":6824,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[6012,1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/posts\/6823"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/users\/22552"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/comments?post=6823"}],"version-history":[{"count":1,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/posts\/6823\/revisions"}],"predecessor-version":[{"id":6825,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/posts\/6823\/revisions\/6825"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/media\/6824"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/media?parent=6823"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/categories?post=6823"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/tags?post=6823"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}