{"id":4563,"date":"2020-12-17T13:38:11","date_gmt":"2020-12-17T18:38:11","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/pulmonary\/?p=4563"},"modified":"2020-12-17T13:38:11","modified_gmt":"2020-12-17T18:38:11","slug":"actionable-lung-cell-responses-to-sars-cov-2-infection","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/pulmonary\/2020\/12\/17\/actionable-lung-cell-responses-to-sars-cov-2-infection\/","title":{"rendered":"Actionable Lung Cell Responses to SARS-CoV-2 Infection"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" width=\"375\" height=\"375\" class=\"wp-image-2852 size-full alignleft\" alt=\"\" src=\"\/pulmonarycenter\/files\/2020\/12\/Kotton-Wilson-Spotlight-image.jpg\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>Teams from Pulmonary Center Faculty members Andrew Wilson and Darrell Kotton (and collaborators) recently published exciting new findings about how alveolar epithelial type 2 cells respond to SARS-CoV-2 infection!<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&#8220;Briefly, we found that there are changes to cellular proteins (the proteome and phosphoproteome) that occur as soon as 1 hour after infection with SARS-CoV-2. We defined those changes and how they evolve over time following infection and demonstrate a variety of pathways that are perturbed in this process. Those pathways represent potential drug targets that could be useful for drug development.&#8221;<\/p>\n<p><strong>-Andrew Wilson, M.D.<\/strong><\/p>\n<p><strong>For more information, please see the following links:<\/strong><\/p>\n<p><strong><span style=\"text-decoration: underline;\">Press Releases:<\/span><\/strong><br \/>\n<a href=\"https:\/\/www.livemint.com\/science\/health\/decoded-how-covid-19-hijacks-and-damages-lung-cells-11607843559657.html\" target=\"_blank\" rel=\"noopener noreferrer\">MINT &#8211; Dec. 13th, 2020<\/a><br \/>\n<a href=\"https:\/\/www.technologynetworks.com\/analysis\/news\/how-sars-cov-2-hijacks-and-rapidly-damages-human-lung-cells-343553\" target=\"_blank\" rel=\"noopener noreferrer\">TECHNOLOGY NETWORKS &#8211; Dec. 3rd, 2020<\/a><\/p>\n<p><strong><span style=\"text-decoration: underline;\">Full Article:<\/span><\/strong><br \/>\n<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1097276520308285?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer\"><span>Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; &nbsp; &nbsp; Teams from Pulmonary Center Faculty members Andrew Wilson and Darrell Kotton (and collaborators) recently published exciting new findings about how alveolar epithelial type 2 cells respond to SARS-CoV-2 infection! &nbsp; &nbsp; &#8220;Briefly, we found that there are changes to cellular proteins (the proteome and phosphoproteome) that occur as soon as 1 hour [&hellip;]<\/p>\n","protected":false},"author":16527,"featured_media":4564,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[6012],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/posts\/4563"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/users\/16527"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/comments?post=4563"}],"version-history":[{"count":1,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/posts\/4563\/revisions"}],"predecessor-version":[{"id":4565,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/posts\/4563\/revisions\/4565"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/media\/4564"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/media?parent=4563"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/categories?post=4563"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/tags?post=4563"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}