{"id":4539,"date":"2020-11-03T11:31:43","date_gmt":"2020-11-03T16:31:43","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/pulmonary\/?p=4539"},"modified":"2020-11-03T17:14:07","modified_gmt":"2020-11-03T22:14:07","slug":"past-infections-with-other-coronaviruses-influence-covid-19","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/pulmonary\/2020\/11\/03\/past-infections-with-other-coronaviruses-influence-covid-19\/","title":{"rendered":"Past infections with other coronaviruses influence COVID-19"},"content":{"rendered":"<p><img loading=\"lazy\" src=\"\/pulmonary\/files\/2020\/11\/spotlight-pic-2-1024x658.png\" alt=\"\" width=\"1024\" height=\"658\" class=\"aligncenter wp-image-4542 size-large\" srcset=\"https:\/\/www.bumc.bu.edu\/pulmonary\/files\/2020\/11\/spotlight-pic-2-1024x658.png 1024w, https:\/\/www.bumc.bu.edu\/pulmonary\/files\/2020\/11\/spotlight-pic-2-467x300.png 467w, https:\/\/www.bumc.bu.edu\/pulmonary\/files\/2020\/11\/spotlight-pic-2-768x494.png 768w, https:\/\/www.bumc.bu.edu\/pulmonary\/files\/2020\/11\/spotlight-pic-2.png 1496w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>Endemic coronaviruses have been causing human infections for many years, long before the recent emergence of SARS-CoV-2 which causes COVID-19. Jay Mizgerd and Manish Sagar (from the Section of Infectious Diseases) hypothesized that infections with endemic coronavirus, which are molecularly similar to SARS-CoV-2, might elicit cross-reactive immunity that influences what happens during a SARS-CoV-2 infection. They tested this hypothesis using medical records from the Boston Medical Center. They found that those who had been <img loading=\"lazy\" src=\"\/pulmonarycenter\/files\/2020\/11\/spotlight-pic-1-150x150.png\" alt=\"\" width=\"150\" height=\"150\" class=\"size-thumbnail wp-image-2798 alignleft\" \/>diagnosed within the prior 5 years with an endemic coronavirus infection fared better during COVID-19, compared to others who were similarly tested in the same time-frame but did not have endemic coronaviruses diagnosed. The rates of SARS-CoV-2 infection were similar between the groups, as were the rates of SARS-CoV-2 hospitalization. However, those with prior coronavirus <img loading=\"lazy\" src=\"\/pulmonarycenter\/files\/2020\/11\/spotlight-pic-3-150x150.png\" alt=\"\" width=\"150\" height=\"150\" class=\"size-thumbnail wp-image-2800 alignleft\" \/>diagnoses were less likely to need ICU admission and were less likely to die. These findings suggest that immunity against endemic coronaviruses may cross-react with SARS-CoV-2 and help<br \/>\nprevent serious infections in the lung. The study is published in the <a href=\"https:\/\/www.jci.org\/articles\/view\/143380\" target=\"_blank\" rel=\"noopener noreferrer\">Journal of Clinical Investigation<\/a>.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Endemic coronaviruses have been causing human infections for many years, long before the recent emergence of SARS-CoV-2 which causes COVID-19. Jay Mizgerd and Manish Sagar (from the Section of Infectious Diseases) hypothesized that infections with endemic coronavirus, which are molecularly similar to SARS-CoV-2, might elicit cross-reactive immunity that influences what happens during a SARS-CoV-2 infection. [&hellip;]<\/p>\n","protected":false},"author":16527,"featured_media":4542,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[6012],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/posts\/4539"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/users\/16527"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/comments?post=4539"}],"version-history":[{"count":3,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/posts\/4539\/revisions"}],"predecessor-version":[{"id":4543,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/posts\/4539\/revisions\/4543"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/media\/4542"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/media?parent=4539"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/categories?post=4539"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/tags?post=4539"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}