{"id":3671,"date":"2019-04-02T14:47:14","date_gmt":"2019-04-02T18:47:14","guid":{"rendered":"http:\/\/www.bumc.bu.edu\/pulmonary\/?p=3671"},"modified":"2019-04-02T14:47:14","modified_gmt":"2019-04-02T18:47:14","slug":"pj-maglione-new-paper","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/pulmonary\/2019\/04\/02\/pj-maglione-new-paper\/","title":{"rendered":"PJ Maglione New Paper"},"content":{"rendered":"<p><img loading=\"lazy\" src=\"\/pulmonary\/files\/2019\/04\/JCI-pic-224x300.jpg\" alt=\"\" width=\"224\" height=\"300\" class=\"size-medium wp-image-3672 alignright\" srcset=\"https:\/\/www.bumc.bu.edu\/pulmonary\/files\/2019\/04\/JCI-pic-224x300.jpg 224w, https:\/\/www.bumc.bu.edu\/pulmonary\/files\/2019\/04\/JCI-pic.jpg 300w\" sizes=\"(max-width: 224px) 100vw, 224px\" \/><\/p>\n<p><span>This work demonstrated that B cells, which typically protect us against infection, function abnormally and promote interstitial lung disease in patients with common variable immunodeficiency (CVID). CVID is a primary immunodeficiency, a type of disorder where individuals have an immune system that does not function properly \u2013 causing infections and, for reasons not understood, also leading to \u201cnon-infectious\u201d complications like interstitial lung disease. Dr. Maglione and colleagues were able to therapeutically target B cells and ameliorate the lung disease in all 11 patients they treated. Using this approach, they were able spare the patients side effects of more broadly immunosuppressive therapies. Lastly, they were able to determine that a protein known as B cell activating factor, or BAFF, is an important driver of the dysregulated B cells that drive this lung disease through a specific interaction BAFF has with BAFF receptor. \u00a0This disease pathway mediated by BAFF may be a useful target for therapeutic interventions in these patients.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This work demonstrated that B cells, which typically protect us against infection, function abnormally and promote interstitial lung disease in patients with common variable immunodeficiency (CVID). CVID is a primary immunodeficiency, a type of disorder where individuals have an immune system that does not function properly \u2013 causing infections and, for reasons not understood, also [&hellip;]<\/p>\n","protected":false},"author":13920,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[6012],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/posts\/3671"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/users\/13920"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/comments?post=3671"}],"version-history":[{"count":1,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/posts\/3671\/revisions"}],"predecessor-version":[{"id":3673,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/posts\/3671\/revisions\/3673"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/media?parent=3671"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/categories?post=3671"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/tags?post=3671"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}