{"id":64,"date":"2007-11-09T11:47:58","date_gmt":"2007-11-09T15:47:58","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/pulmonary\/pastandpresent\/"},"modified":"2024-08-07T14:09:55","modified_gmt":"2024-08-07T18:09:55","slug":"pasthighlights","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/pulmonary\/about-us\/history\/pasthighlights\/","title":{"rendered":"Past Highlights"},"content":{"rendered":"

Notable discoveries and contributions to modern medicine from the Boston University School of Medicine Pulmonary Section:<\/p>\n

Pre-Snider Era (1940s-1968)<\/strong><\/h2>\n

\"\"Description of a device for timed vital capacity measurements: the spirometer and use of the FEV1 as a clinical tool for assessing obstructive lung disease. (Gaensler EA. Science 1951; 114:114)\"\"<\/p>\n

Description of the criteria for removal of lung parenchyma in emphysema: the origins of lung reduction surgery. (Gaensler E. Ann Thorac Surg 1965; 1:332\u2013362)<\/p>\n

 <\/p>\n

Snider Era (1968-1986)<\/strong><\/h2>\n

\"\"Description of the xray findings and response to steroids of eosinophilic pneumonia. (Jederlinic PJ, Sicilian L, Gaensler EA. Chest 1975; 68:665-71)<\/p>\n

Differentiation of the pathologic entities of UIP and DIP. (Carrington CB, Gaensler EA, Coutu RE, et al. N Engl J Med 1978; 298:801)<\/p>\n

Description of the first reproducible small animal models of emphysema with pancreatic elastase: the chemical origins of the protease-anti-protease balance theory. (Karlinsky JB, Snider GL. Am Rev Respir Dis 1978; 117:1109\u20131133)\"\"<\/p>\n

Description of the first reproducible small animal model of pulmonary fibrosis and acute lung injury with bleomycin. (Snider GL, Hayes JA, Korthy AL. Am Rev Respir Dis 1978; 117: 1099-1108)<\/p>\n

Description of the first instrument for sterile sampling of the lower respiratory tract during fiberoptic bronchoscopy: the protected brush. (Wimberley N, Faling LJ, Bartlett JG. Am Rev Respir Dis. 1979 Mar; 119(3):337\u2013343)<\/p>\n

\"\"Description of spurious hypoxemia in patients with high white blood cell counts: leukocyte larceny. (Fox MJ, Brody JS, Weintraub LR. Am J Med 1979; 67:742-746)<\/p>\n

Description of the entity of chronic necrotizing pulmonary aspergillosis infection. (Binder RE, Faling, LJ, Pugatch, RD, et al. Medicine 1982; 61,109-124)Description of the first lymphocyte specific chemotactic cytokine: cloning of Interleukin-16. (Cruikshank WW and Center, DM .J Immunol. 1982 Jun; 128(6):2563-8)<\/p>\n

Description of the Clinical entity Bronchiolitis Obliterans Organizing Pneumonia: BOOP. (Epler GR, Colby TV, McLoud TC, Carrington CB, Gaensler. EA. N Engl J. Med 1985; 312:152\u20138)\"\"<\/p>\n

First description of biologic effects of protein products of HIV-1 independent of infection: the chemotactic and activating functions of gp120. (Kornfeld, H,Cruikshank, WW, Pyle, SW; Berman, J. S.; Center. D. M. Nature, 1988, 335, 445-448)<\/p>\n

 <\/p>\n

Post-Snider Era (1986-present)<\/strong><\/h2>\n

\"\"Description of engraftment of stem cell-derived populations in the injured lung (Kotton DN, Ma BY, Cardoso WV, Sanderson EA, Summer RS, Williams MC, Fine A. Development. 2001 Dec;128(24):5181-8.<\/p>\n

Description of fundamental mechanisms controlling early embryonic lung development (reviewed in:Cardoso WV, L\u00fc J. Development. 2006 May; 133(9):1611-24)<\/p>\n

Description of the airway transcriptome as a tool for determining genes associated with lung cancer and COPD. (Spira,A., Beane,J., Shah,V., Liu,G., Schembri,F., Yang,X., Palma,J. and Brody, PNAS 2004 101 27 10143-10148. Spira A, Brody JS et al..Nat Med. 2007 Mar; 13(3):361-6)<\/p>\n","protected":false},"excerpt":{"rendered":"

Notable discoveries and contributions to modern medicine from the Boston University School of Medicine Pulmonary Section: Pre-Snider Era (1940s-1968) Description of a device for timed vital capacity measurements: the spirometer and use of the FEV1 as a clinical tool for assessing obstructive lung disease. (Gaensler EA. Science 1951; 114:114) Description of the criteria for removal […]<\/p>\n","protected":false},"author":1196,"featured_media":0,"parent":65,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/pages\/64"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/users\/1196"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/comments?post=64"}],"version-history":[{"count":13,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/pages\/64\/revisions"}],"predecessor-version":[{"id":6761,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/pages\/64\/revisions\/6761"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/pages\/65"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/pulmonary\/wp-json\/wp\/v2\/media?parent=64"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}