Martin Joyce-Brady, M.D.
Associate Professor of Medicine
Director, Pulmonary, Respiratory Therapy and Ventilator Care Services
Radius Specialty Hospital-Boston/Quincy
Medical School: University of Maryland School of Medicine
Internship: Boston City Hospital
Residency: Boston City Hospital
Chief Residency: Boston City Hospital
Fellowship: The Pulmonary Center at Boston University
- Lung Development
- Regulation of Perinatal Lung Gene Expression
- Role of lung and lung lining fluid glutathione metabolism in antioxidant defense
- Outcomes of Patients requiring Long Term Mechanical Ventilation
- Ventilator associated pneumonia in the Long Term Acute Care Hospital setting
- Critical Care Medicine
Dr. Joyce-Brady is Associate Professor in the Department of Medicine. He is an Attending Physician for the Medical Intensive Care Unit and the Pulmonary Consultation Service at Boston Medical Center . He is also the Director of Pulmonary, Respiratory Therapy and Ventilator Care Services at The Radius Specialty Hospital-Boston and Quincy.
Dr. Joyce-Brady’s research is focused on the response of the developing and the adult lung to oxidant stress. His focus is on glutathione and glutathione metabolism, particularly in the lung lining fluid that baths the surface of the lung. His laboratory has characterized the key enzyme in glutathione metabolism, gamma-glutamyl transferase (GGT), and a mouse model of GGT deficiency, the GGTenu1 mouse. This work has revealed the presence of glutathione metabolism in LLF and a novel target that can augment lung lining fluid glutathione content under oxidant stress associated with inflammatory lung disease.
His laboratory has also utilized several tools to study gene expression in the developing lung, including suppression subtractive hybridization, differential display and microarrays. Selected genes that are developmentally regulated in the perintal period are now under study in adult lung to decipher their role in repair following injury. One such gene, fibulin-5, is a regulator of elastogenesis and severe emphysema develops with fibulin-5 deficiency in the knock out lung. Fibulin-5 is a matrix protein that also functions in antioxidant defense and current studies are aimed at integrating the loss of elastogenesis with oxidant stress.
For more details see the web page for Dr. JC Jean
His clinical interests center on the outcomes of patients requiring long term mechanical ventilatory support in the environment of the long term acute care hospital (LTACH). He has defined a tool to predict weaning success and the epidemiology of ventilator-associated pneumonia (VAP) in his LTACH, Radius Specialty Hospital. The overall goal is to increase translational research to improve outcomes in this ever expanding population of LTACH patients.
Please see BU Profile for complete Publications list
- Lung Lining Fluid Glutathione Attenuates IL13-Induced Asthma
- The importance of gamma-glutamyl transferase in lung glutathione homeostasis and antioxidant defense
- Coordinate expression of fibulin-5/DANCE and elastin during lung injury repair
- Gamma-Glutamyltransferase and Its Isoform Mediate an Endoplasmic Reticulum Stress Response
- Hypoxia results in an HIF-1-dependent induction of brain-specific aldolase C
- Fibulin-5 gene expression in human lung fibroblasts is regulated by TGF
- Epidemiology of Ventilator-associated pneumonia in a Long-term acute care hospital
- Bioinformatics web site
- Mass.Gov – Massachusetts Board of Registration in Medicine
- NHLBI – National Heart, Lung & Blood
- Radius Specialty Hospital: Pulmonary Rehabilitation
- NALTH web site (http://www.nalth.org)