{"id":18628,"date":"2022-04-29T21:28:34","date_gmt":"2022-04-30T01:28:34","guid":{"rendered":"http:\/\/www.bumc.bu.edu\/ppb\/?post_type=profile&p=18628"},"modified":"2022-04-30T00:16:27","modified_gmt":"2022-04-30T04:16:27","slug":"scott-s-downing-ph-d","status":"publish","type":"profile","link":"https:\/\/www.bumc.bu.edu\/ppb\/profile\/scott-s-downing-ph-d\/","title":{"rendered":"Scott S. Downing, Ph.D."},"content":{"rendered":"

Dr.\u00a0Scott Downing\u00a0earned his doctoral degree in Pharmacology from the Boston University School of Medicine where he trained under the supervision of\u00a0Dr. Terrell Gibbs. \u00a0Dr. Downing completed a post-doctoral fellowship in the Department of Pharmacology and Experimental Therapeutics where his research included\u00a0investigations of novel therapeutic approaches for the treatment of anxiety and cognitive deficits by screening for and characterizing potential drugs at application-specific GABAA<\/sub> receptor subtypes.\u00a0<\/span>While a post-doctoral fellow, Dr. Downing co-led a high-throughput screening center conducting ion channel screening projects for three pharmaceutical companies. \u00a0He r<\/span>edesigned a high-throughput, drug screening system to automate data analysis and reduce operational complexity, increasing the screening efficiency for ion channel modulators by 500%. \u00a0He wrote the computer codes for<\/span>\u00a0digital signal processing and statistical analysis (digital filtering, nonlinear, least squares curve fitting and t tests) with LabVIEW and MATLAB. He also constructed a client\/server network with Microsoft Windows 2000 and XP clients, MAC clients and a Redhat Linux server to centralize data storage and provide distributed data collection \/ analysis.<\/span><\/p>\n

Dr. Downing is currently a member of our in vivo<\/em> electrophysiology<\/a> team. \u00a0His work is focused on studying potential therapeutics for cognitive and memory enhancement. He\u00a0has developed techniques and code (MATLAB) to analyze in-vivo<\/em>\u00a0electrophysiological data derived from our recordings of hippocampal place cell activity. He has implemented unsupervised machine learning techniques to sort the large number of waveforms recorded through each electrode and developed methods to remove hardware-based filtering artifacts from recorded data.<\/p>\n

Select Publications<\/h3>
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Ratner MH,\u00a0Downing SS<\/strong>, Guo O, Odamah KE, Stewart TM, Kumaresan V, Robitsek RJ, Xia W, Farb DH. Prodromal dysfunction of \u03b15GABA-A receptor modulated hippocampal ripples occurs prior to neurodegeneration in the TgF344-AD rat model of Alzheimer\u2019s disease.<\/a> \u00a0Heliyon,\u00a0September 2021, 7(9): e07895. PMID: 34568591<\/a><\/p>\n

Downing, S.S.,<\/strong> Lee, Y.T., Farb, D.H., and Gibbs, T.T. (2005) Benzodiazepine Modulation of Partial Agonist Efficacy and Spontaneously Active GABAA Receptors Support a Two-State Model of Allosteric Modulation<\/a>. British Journal of Pharmacology, Aug;145(7):894<\/p>\n

Berezhnoy, D., Gravielle, MC., Downing, S.<\/strong>, Kostakis, E., Basile, A.S., Skolnick, P., Gibbs, T.T., and Farb, D.H. (2008) Pharmacological Properties of DOV 315,090, an ocinaplon metabolite.<\/a> BMC Pharmacology, Jun 13; 8(1):11<\/p>\n

<\/div>\n<\/div>\n\n

Select Abstracts<\/h3>

\n<\/strong><\/p>\n

Ratner\u00a0<\/sup>MH, Downing SS,\u00a0<\/strong>Guo O, Odamah KA, Stewart TM, Kumaresan V,\u00a0Xia W,\u00a0Farb DH: Loss of tonic inhibitory control of sharp wave ripples in the TgF344-AD rat<\/a>. \u00a0Program\/Poster No. P232.10.\u00a0<\/span>\u00a0Presented at the Society for Neuroscience Annual Meeting, November 2021.\u00a0<\/span><\/p>\n

Ratner\u00a0<\/sup>MH, Downing SS,\u00a0<\/strong>Guo O, Odamah KA, Stewart TM, Kumaresan V,\u00a0Xia W,\u00a0Farb DH: Does Modulation of Tonic Inhibition Control Sharp Wave Ripples and Hippocampal Place Cell Dynamics?<\/a> \u00a0Program\/Poster No. P234.02.<\/span>\u00a0Presented at the Society for Neuroscience Annual Meeting, November 2021.\u00a0<\/span><\/p>\n

Kumaresan V, Ratner MH, Sugunan K, Downing SS<\/strong>, Casarella A, Li N, Joyal AA, Farb DH: Regulation of Activity Dependent Synaptic Plasticity and Synaptic Expression of Glutamate Receptors by the Neurosteroid Pregnenolone Sulfate: Implications for Learning and Memory<\/a>. Program\/Poster No. 576.25. Presented at Society for Neuroscience Annual Meeting, Washington, D.C.: Society for Neuroscience, 2017. Online.<\/p>\n

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