{"id":18136,"date":"2022-02-22T17:52:02","date_gmt":"2022-02-22T22:52:02","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/ppb\/?post_type=profile&#038;p=18136"},"modified":"2022-06-08T17:04:06","modified_gmt":"2022-06-08T21:04:06","slug":"benjamin-wolozin-m-d-ph-d","status":"publish","type":"profile","link":"https:\/\/www.bumc.bu.edu\/ppb\/profile\/benjamin-wolozin-m-d-ph-d\/","title":{"rendered":"Benjamin Wolozin, M.D., Ph.D."},"content":{"rendered":"<p><strong>Principal Investigator: <a href=\"https:\/\/sites.bu.edu\/wolozinlab\/\"><span style=\"color: #3366ff;\">Laboratory of Neurodegeneration<\/span><\/a> <\/strong><\/p>\n<h3>Research Interests<strong> <\/strong><\/h3>\n<p class=\"p1\"><a href=\"https:\/\/www.youtube.com\/watch?v=LokutAVYhVw\">https:\/\/www.youtube.com\/watch?v=LokutAVYhVw<\/a><\/p>\n<h4>Pathophysiology of Neurodegeneration: Molecular and cellular Biology<\/h4>\n<p><strong>Overview:<\/strong> The goal of our research is to understand the mechanisms underlying neurodegenerative diseases, and then to use this understanding to develop novel interventions for disease.\u00a0 Much of our research focuses on the central concept of regulated protein aggregation.<strong>\u00a0 <\/strong>Protein aggregation in neurodegenerative diseases is classically thought to occur as an unwanted byproduct of protein misfolding.\u00a0 Human genetic studies increasingly highlight the importance of RNA binding proteins in neurodegenerative diseases.\u00a0 This is important because RNA binding proteins use protein aggregation as part of a normal regulated, physiological mechanism controlling protein synthesis. \u00a0Aggregated RNA binding proteins for stress granules, transport granules, P bodies, as well as participate in physiological functions, such as activity dependent protein synthesis.\u00a0 Our research investigates the hypothesis that dysfunction of RNA granules causes neurodegenerative diseases.\u00a0 Over active stress granule formation could contribute to neurodegeneration by altering patterns of protein synthesis and sequestering proteins that regulate cell death processes.\u00a0 Hypo-active stress granules, leads to inadequate neuroprotection.\u00a0 <strong><\/strong><strong><\/strong><\/p>\n<h3><a href=\"https:\/\/sites.bu.edu\/wolozinlab\/\"><span style=\"color: #3366ff;\">Lab Page<\/span><\/a><\/h3>\n<h3><span style=\"color: #3366ff;\"><a href=\"https:\/\/profiles.bu.edu\/Benjamin.Wolozin\" style=\"color: #3366ff;\">Publications<\/a><\/span><\/h3>\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h3 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Recent News<\/h3><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<ul>\n<li><a title=\"Michael J. Fox and Parkinson's Disease Research\" href=\"https:\/\/www.bumc.bu.edu\/ppb\/2009\/04\/01\/wolozinchannel5\/\">Ben Wolozin, M.D., Ph.D. on News Center 5: Michael J. Fox and Parkinson\u2019s Disease Research<\/a><\/li>\n<\/ul>\n<p><\/div>\n<\/div>\n\n","protected":false},"author":15890,"template":"","_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/profile\/18136"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/profile"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/types\/profile"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/users\/15890"}],"version-history":[{"count":4,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/profile\/18136\/revisions"}],"predecessor-version":[{"id":19662,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/profile\/18136\/revisions\/19662"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/media?parent=18136"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}