Dr. Jiang was a Postdoc Fellow in the Laboratory of Neurodegeneration mentored by Dr. Benjamin Wolozin. Her previous work demonstrated that propagated tau oligomers (but not tau fibrils) induce pathological changes in RNA metabolism and neurodegeneration. Upon that, Dr. Jiang developed an optogenetic system for controlling tau aggregation, which brought in a seminal discovery that tau oligomerization drives the accumulation of RNA binding protein HNRNPA2B1 and N6-methyladenosine modified transcripts in the aggregated tau complex.<\/p>\n
Dr. Jiang has also lead on the generation of human 3D iPSC M\/AstAD based models of AD for the exploration of molecular mechanism and drug screening. Her research interests include: 1) Protein-Protein and Protein-RNA interactions in AD and related dementia; 2) Molecular mechanism of Tau prion-like propagation in Braak stages of AD; 3) Neuron-glia interactions in pathogenesis of AD and PD; 4) iPSC-induced 3D brain organoid models of neurodegenerative diseases and precision medicine; 5) Development of novel therapeutics for neurodegenerative diseases.<\/p>\n
November 22, 2021<\/strong> Sep 03, 2021<\/strong> Sep 14, 2021<\/strong> Dr. Jiang\u2019s research article published on Molecular Cell was reported by other News Media:<\/p>\n August 30, 2021<\/strong> August 27, 2021<\/strong>
\nDr. Jiang is invited as speaker on the Symposium of Single-cell genomics stem cells at AD\/PD22: 16th International Conference on Alzheimer\u2019s & Parkinson\u2019s Diseases taking place Online and in Barcelona, Spain during March 15-20, 2022.<\/p>\n
\nDr. Jiang\u2019s findings in Wolozin lab illustrated that oligomeric Tau binds indirectly to N6-methyladenosine (m6A)-modified RNA transcripts in the cytoplasm via the linker RNA-binding protein HNRNPA2B1. This discovery was published on Molecular Cell and marked as Research Highlight by Nature Reviews Molecular Cell Biology: Baumann, K. Tau oligomers are linked to m6A-RNA. Nat Rev Mol Cell Biol (2021). https:\/\/doi.org\/10.1038\/s41580-021-00419-w<\/p>\n
\nDr. Jiang\u2019s publication \u201cInteraction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy\u201d on Mol Cell was recommended and reported by Alzforum News with title: Methylated RNA: A New Player in Tau Toxicity?
\nAlzforum News: https:\/\/www.alzforum.org\/news\/research-news\/methylated-rna-new-player-tau-toxicity.<\/p>\n
\nGenetic Engineering News by Jeffrey S. Buguliskis, Ph.D., title: Alzheimer\u2019s Tau Protein Interacts with RNA to Induce Neurodegeneration, https:\/\/www.genengnews.com\/news\/alzheimers-tau-protein-interacts-with-rna-to-induce-neurodegeneration\/
\nAugust 28, 2021<\/strong>
\nNews-Medical.Net, title: Research analyzes the role of RNA tags in Alzheimer\u2019s disease, https:\/\/www.news-medical.net\/news\/20210828\/Research-analyzes-the-role-of-RNA-tags-in-Alzheimere28099s-disease.aspx<\/p>\n
\nMedical Xpress, title: First study to investigate the role of RNA tags in Alzheimer’s disease, https:\/\/medicalxpress.com\/news\/2021-08-role-rna-tags-alzheimer-disease.html<\/p>\n