{"id":13417,"date":"2017-06-21T11:30:56","date_gmt":"2017-06-21T15:30:56","guid":{"rendered":"http:\/\/www.bumc.bu.edu\/ppb\/?p=13417"},"modified":"2017-06-21T11:30:56","modified_gmt":"2017-06-21T15:30:56","slug":"dr-pietro-cottone-speaks-at-the-royal-societys-of-mice-and-mental-health-facilitating-dialogue-between-basic-and-clinical-neuroscientists","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/ppb\/2017\/06\/21\/dr-pietro-cottone-speaks-at-the-royal-societys-of-mice-and-mental-health-facilitating-dialogue-between-basic-and-clinical-neuroscientists\/","title":{"rendered":"Dr. Pietro Cottone Speaks at The Royal Society&#8217;s &#8220;Of Mice and Mental Health: Facilitating Dialogue Between Basic and Clinical Neuroscientists&#8221;"},"content":{"rendered":"<p><a href=\"https:\/\/www.bumc.bu.edu\/ppb\/people\/faculty\/faculty-profiles\/cottone\/\">Pietro Cottone, Ph.D., Associate Professor of Pharmacology and Psychiatry<\/a>, made a presentation on the &#8220;Neurobiology of Compulsive Eating&#8221; at The Royal Society&#8217;s <a href=\"https:\/\/royalsociety.org\/science-events-and-lectures\/2017\/04\/mental-health\/\">&#8220;Of Mice and Mental Health: Facilitating Dialogue Between Basic and Clinical Neuroscientists<\/a>&#8221;\u00a0in London on\u00a0April 24-25, 2017. Based upon his current research, Dr. Cottone and his research group in the<a href=\"https:\/\/www.bumc.bu.edu\/ppb\/training-program\/laboratories\/lad\/\"> Laboratory of Addictive Disorders<\/a> tested the hypothesis that &#8220;one of the underlying mechanisms of compulsive eating involves the\u00a0negative reinforcing properties palatable food . . .&#8221; \u00a0According to their studies,\u00a0rats who were deprived of regular access to highly palatable food demonstrated &#8220;spontaneous emotional signs of palatable food withdrawal, including anxiety- and depressive-like behavior,&#8221; \u00a0that was &#8220;accompanied by increased corticotropin-releasing factor expression (CRF),&#8221; and that &#8220;administration of a selective CRF1 receptor antagonist . . . was able to block both the overeating . . . and negative emotional state.&#8221; These results are important in ultimately\u00a0discovering novel therapeutics to combat compulsive eating. \u00a0The manuscript with details of this research\u00a0will be published in The Royal Society&#8217;s journal, &#8220;<a href=\"http:\/\/rstb.royalsocietypublishing.org\/\">Philosophical Transactions of the Royal Society B<\/a>.&#8221;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pietro Cottone, Ph.D., Associate Professor of Pharmacology and Psychiatry, made a presentation on the &#8220;Neurobiology of Compulsive Eating&#8221; at The Royal Society&#8217;s &#8220;Of Mice and Mental Health: Facilitating Dialogue Between Basic and Clinical Neuroscientists&#8221;\u00a0in London on\u00a0April 24-25, 2017. Based upon his current research, Dr. Cottone and his research group in the Laboratory of Addictive Disorders [&hellip;]<\/p>\n","protected":false},"author":1327,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1783],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/posts\/13417"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/users\/1327"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/comments?post=13417"}],"version-history":[{"count":3,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/posts\/13417\/revisions"}],"predecessor-version":[{"id":13420,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/posts\/13417\/revisions\/13420"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/media?parent=13417"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/categories?post=13417"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/tags?post=13417"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}