{"id":99,"date":"2008-08-05T11:53:07","date_gmt":"2008-08-05T15:53:07","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/ppb\/resources\/summary\/"},"modified":"2010-11-18T12:21:42","modified_gmt":"2010-11-18T17:21:42","slug":"summary","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/ppb\/education\/pharmacology\/problem-sets\/problem-1\/summary\/","title":{"rendered":"PHARMACOKINETICS OF CHLORAMPHENICOL"},"content":{"rendered":"
Department of Pharmacology and Experimental Therapeutics<\/a>
\nBoston University School of Medicine<\/a><\/address>\n
\n
Print this page (Choose Print…<\/em> under the File<\/em> menu in your Web browser) and then click here<\/a> to return to the problem set.<\/h5>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Summary Table (Species: Dog, Weight: 16.5, 18.0 kg)<\/th>\n<\/tr>\n
I.<\/strong><\/td>\nOrder of elimination kinetics<\/td>\n_____ – order<\/td>\n<\/tr>\n
II.<\/strong><\/td>\nElimination half-life<\/td>\n_____ min<\/td>\n<\/tr>\n
III.<\/strong><\/td>\nApparent volume of distribution<\/td>\n___ liters
\nin 16.5 kg dog<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n_____ liters\/kg<\/td>\n<\/tr>\n
IV.<\/strong><\/td>\nVd in relation to body fluid compartments<\/td>\n_____% body weight<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n_____body fluid volume<\/td>\n<\/tr>\n
V.<\/strong><\/td>\nGastrointestinal absorption:<\/td>\n<\/tr>\n
<\/td>\n<\/td>\noral bioavailability<\/td>\n_____ %<\/td>\n<\/tr>\n
<\/td>\n<\/td>\nrapidity of absorption<\/td>\n<\/td>\n<\/tr>\n
VI.<\/strong><\/td>\nCumulative percent of dose excreted in urine<\/td>\n<\/tr>\n
<\/td>\n<\/td>\ni.v. route<\/td>\n_____ %<\/td>\n<\/tr>\n
<\/td>\n<\/td>\np.o. route<\/td>\n_____ %<\/td>\n<\/tr>\n
VII.<\/strong><\/td>\nRenal clearance of chloramphenicol<\/td>\n_____ ml\/min<\/td>\n<\/tr>\n
VIII.<\/strong><\/td>\nMechanisms of renal clearance of chloramphenicol<\/td>\n_____<\/td>\n<\/tr>\n
IX.<\/strong><\/td>\nRelationship between renal clearance and urinary pH<\/td>\n_____<\/td>\n<\/tr>\n
X.<\/strong><\/td>\nTotal clearance<\/td>\n_____ ml\/min<\/td>\n<\/tr>\n
XI.<\/strong><\/td>\nRenal clearance of chloramphenicol glucuronide<\/td>\n96.3 ml\/min<\/td>\n<\/tr>\n
<\/td>\n<\/td>\nCumulative % of dose excreted in urine as chloramphenicol glucuronide:<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\ni.v. route<\/td>\n60 %<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/td>\np.o. route<\/td>\n55 %<\/td>\n<\/tr>\n
<\/td>\n<\/td>\nMajor mechanism of elimination of chloramphenicol glucuronide<\/td>\n_____<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Department of Pharmacology and Experimental Therapeutics Boston University School of Medicine Print this page (Choose Print… under the File menu in your Web browser) and then click here to return to the problem set. Summary Table (Species: Dog, Weight: 16.5, 18.0 kg) I. Order of elimination kinetics _____ – order II. Elimination half-life _____ min […]<\/p>\n","protected":false},"author":1135,"featured_media":0,"parent":75,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages\/99"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/users\/1135"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/comments?post=99"}],"version-history":[{"count":5,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages\/99\/revisions"}],"predecessor-version":[{"id":21923,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages\/99\/revisions\/21923"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages\/75"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/media?parent=99"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}