{"id":8959,"date":"2013-10-07T12:09:22","date_gmt":"2013-10-07T16:09:22","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/ppb\/?page_id=8959"},"modified":"2022-06-06T14:44:08","modified_gmt":"2022-06-06T18:44:08","slug":"lccb","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/ppb\/education\/pharmacology\/training-program\/laboratories\/lccb\/","title":{"rendered":"Laboratory of Cancer Cell Biology"},"content":{"rendered":"<h3><a href=\"\/ppb\/files\/2013\/10\/Croppedmultipolara.jpg\"><img loading=\"lazy\" class=\"size-large wp-image-8993 aligncenter\" title=\"Croppedmultipolara\" alt=\"Croppedmultipolara\" src=\"\/ppb\/files\/2013\/10\/Croppedmultipolara-1024x796.jpg\" width=\"540\" height=\"420\" srcset=\"https:\/\/www.bumc.bu.edu\/ppb\/files\/2013\/10\/Croppedmultipolara-1024x796.jpg 1024w, https:\/\/www.bumc.bu.edu\/ppb\/files\/2013\/10\/Croppedmultipolara-385x300.jpg 385w\" sizes=\"(max-width: 540px) 100vw, 540px\" \/><\/a><\/h3>\n<h3><b>Research<\/b><\/h3>\n<p><b> <\/b><a href=\"https:\/\/www.bumc.bu.edu\/ppb\/profile\/neil-j-ganem-ph-d\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #3366ff;\">Dr. Neil Ganem<\/span><\/a>\u2019s laboratory uses a combination of high-resolution microscopy, genome-wide RNAi screening, cell biology, and bioinformatics to study the causes and consequences of genome instability in human cancer. Dr. Ganem\u2019s lab seeks to define the tumor suppression mechanisms that \u00a0limit the proliferation of highly abnormal aneuploid cells, as well as to identify the common genetic adaptations made by cancer cells to overcome these growth barriers.<\/p>\n<p>Current projects in the lab are aimed at:<\/p>\n<p>1) Identifying the cellular defects that trigger activation of the Hippo tumor suppressor pathway in aneuploid cells.<\/p>\n<p>2) Examining the consequences of oncogenic signaling on mitotic fidelity and chromosome segregation.<\/p>\n<p>3) Characterizing novel regulators of growth factor signaling and the Hippo pathway, as uncovered by a functional RNAi screen.<\/p>\n<p>&nbsp;<\/p>\n<p>Dr. Ganem is currently accepting Rotation Students.<\/p>\n<h2>People<\/h2>\n<h3>Principal Investigator<\/h3>\n\n\t<ul class=\"profile-listing profile-format-advanced\">\n\t\t\t\t\t\n<li class=\"profile-item profile-item-advanced has-title post-18040 profile type-profile status-publish hentry\">\n\t<a href=\"https:\/\/www.bumc.bu.edu\/ppb\/profile\/neil-j-ganem-ph-d\/\" class=\"profile-link profile-link-advanced\">\n\t\t\t\t\t<figure class=\"profile-photo profile-photo-advanced\"><img width=\"150\" height=\"150\" src=\"\/ppb\/files\/2022\/02\/Ganem_Neil-2-5x3-5-300x300.jpg\" alt=\"Neil J. Ganem\" \/><\/figure>\t\t\t\t<h6 class=\"profile-name profile-name-advanced\">Neil J. Ganem, Ph.D.<\/h6>\n\t\t<p class=\"profile-title profile-title-advanced\">Associate Professor of Pharmacology, Physiology &#038; Biophysics and Medicine<\/p>\t<\/a>\n\n\t\n<\/li>\n\t\t\t<\/ul>\n\n<h3>Graduate Students<\/h3>\n<div class=\"CCBGradStudentGrid\">\n<div class=\"CCBGradStudentImg\"><img loading=\"lazy\" src=\"\/ppb\/files\/2013\/10\/Unknown-150x150.jpeg\" alt=\"\" class=\"alignnone size-thumbnail wp-image-9750\" width=\"150\" height=\"150\" \/><div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h5 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Amanda Bolgioni<\/h5><div class=\"bu_collapsible_section\" style=\"display: none;\">Amanda is a second year graduate student in the Department of Pharmacology and Experimental Therapeutics at Boston University. She joined the Ganem lab in May 2014. Amanda completed her undergraduate degree in Biochemistry at the University of Vermont (UVM) in 2013. Her undergraduate research at UVM focused on the importance of serotonin for gastrointestinal function, specifically how this neurotransmitter contributes to inflammatory bowel disease and irritable bowel syndrome when its regulation is altered.\u00a0 Amanda\u2019s research in the Ganem Lab is aimed at understanding the role of the Hippo pathway in regulating the \u201cmitotic clock.\u201d<\/div>\n<\/div>\n<\/div>\n<div class=\"CCBGradStudentImg\"><img loading=\"lazy\" src=\"\/ppb\/files\/2013\/10\/Sanghee-Lim-Photo-150x150.jpg\" alt=\"\" class=\"alignnone size-thumbnail wp-image-10050\" width=\"150\" height=\"150\" srcset=\"https:\/\/www.bumc.bu.edu\/ppb\/files\/2013\/10\/Sanghee-Lim-Photo-150x150.jpg 150w, https:\/\/www.bumc.bu.edu\/ppb\/files\/2013\/10\/Sanghee-Lim-Photo-300x300.jpg 300w, https:\/\/www.bumc.bu.edu\/ppb\/files\/2013\/10\/Sanghee-Lim-Photo.jpg 756w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/><div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h5 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Sanghee Lim<\/h5><div class=\"bu_collapsible_section\" style=\"display: none;\">Sanghee Lim is an MD\/PhD student in the Department of Pharmacology and Experimental Therapeutics. He joined Dr. Ganem&#8217;s lab in the summer of 2014 following the completion of his pre-clinical studies at the BU School of Medicine. Sanghee graduated from the College of Arts and Sciences at Boston University through the Seven-Year Medical Education program with a degree in Medical Science and a degree with Honors in Political Science. As an undergraduate at BU, Sanghee worked with Dr. Herbert Cohen in the Renal Section at Boston Medical Center, investigating the relationship between Jade-1 (Gene for Apoptosis and Differentiation in Epithelia-1) and invasive phenotypes in models of renal cell carcinoma. Sanghee&#8217;s current work in the Ganem lab focuses on how oncogenic BRAF signaling contributes to genomic instability and disease progression in melanoma through extra-canonical pathways. <\/div>\n<\/div>\n<\/div>\n<\/div>\n<h3>Lab Members<\/h3>\n<div class=\"CCBMemberGrid\">\n<div class=\"CCBMemberImg\"><img loading=\"lazy\" src=\"\/ppb\/files\/2013\/10\/Allison-150x150.jpg\" alt=\"\" class=\"alignnone size-thumbnail wp-image-8969\" width=\"150\" height=\"150\" \/><div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h5 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Allison Matthews<\/h5><div class=\"bu_collapsible_section\" style=\"display: none;\">Allison Matthews is a research technician in the pharmacology department at Boston University. She joined the lab in July 2013 after completing her undergraduate degree in biochemistry at Mount Holyoke College in 2013. At Mount Holyoke she completed a thesis with Professor Amy Camp on the effect of a small inverted repeat sequence in the sigmaG promoter on <i>Bacillus subtilis<\/i> sporulation. Allison previously worked at MD Anderson Cancer Research Center on STAT3 signaling as well as at Brandeis University in the Haber lab studying the effects of CDC5 overexpression on DNA damage repair.<\/div>\n<\/div>\n<\/div>\n<div class=\"CCBMemberImg\"><img loading=\"lazy\" src=\"\/ppb\/files\/2013\/10\/Hatim1-150x150.jpg\" alt=\"\" class=\"alignnone size-thumbnail wp-image-10051\" width=\"150\" height=\"150\" srcset=\"https:\/\/www.bumc.bu.edu\/ppb\/files\/2013\/10\/Hatim1-150x150.jpg 150w, https:\/\/www.bumc.bu.edu\/ppb\/files\/2013\/10\/Hatim1-300x300.jpg 300w, https:\/\/www.bumc.bu.edu\/ppb\/files\/2013\/10\/Hatim1-1024x1024.jpg 1024w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/><div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h5 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Hatim Mustaly<\/h5><div class=\"bu_collapsible_section\" style=\"display: none;\">Hatim Mustaly is a second year graduate student pursuing a Masters in Medical Sciences at Boston University School of Medicine, Division of Graduate Medical Sciences. Hatim completed his undergraduate degree in Neuroscience at Knox College in 2013. At Knox, his research focused on the mechanism of ventral nerve cord regeneration in <i>Themiste lageniformis<\/i> (Peanut worms). Hatim is currently testing potential small molecule modulators of LATS kinases.<\/div>\n<\/div>\n<\/div>\n<div class=\"CCBMemberImg\"><img loading=\"lazy\" src=\"\/ppb\/files\/2013\/10\/photo-150x150.jpg\" alt=\"\" class=\"alignnone size-thumbnail wp-image-10052\" width=\"150\" height=\"150\" srcset=\"https:\/\/www.bumc.bu.edu\/ppb\/files\/2013\/10\/photo-150x150.jpg 150w, https:\/\/www.bumc.bu.edu\/ppb\/files\/2013\/10\/photo-300x300.jpg 300w, https:\/\/www.bumc.bu.edu\/ppb\/files\/2013\/10\/photo-1024x1024.jpg 1024w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/><div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h5 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Tenny Mudianto<\/h5><div class=\"bu_collapsible_section\" style=\"display: none;\">Tenny Mudianto is an undergraduate student at Boston University, majoring in cell and molecular biology. \u00a0As she enters her third year in college, she has developed an interest in studying cancer cell biology and the cell cycle. Tenny joined Dr. Ganem\u2019s lab in the Fall of 2014 and is examining how cancer cells overcome activation of the hippo tumor suppressor pathway. After graduating, she plans to pursue graduate study in biochemistry.<\/div>\n<\/div>\n<\/div>\n<\/div>\n<h3>Lab Alumni<\/h3>\n<div class=\"CCBAlumni\">\n<div class=\"CCBAlum\"><img loading=\"lazy\" src=\"\/ppb\/files\/2011\/07\/Shenk-Image-150x150.png\" alt=\"\" class=\"alignnone size-thumbnail wp-image-5044\" width=\"150\" height=\"150\" \/><strong>Elizabeth Shenk, Ph.D.<\/strong><br \/>\n<strong>Position:<\/strong><span>\u00a0Staff Scientist at Alliance Pharmaceuticals, Boston, MA\u00a0<\/span><\/div>\n<\/div>\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h3 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Lab Photos<\/h3><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<p><div id='gallery-1' class='gallery galleryid-18040 gallery-columns-2 gallery-size-medium'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='\/ppb\/files\/2013\/10\/Print7a.jpg'><img width=\"420\" height=\"300\" src=\"\/ppb\/files\/2013\/10\/Print7a-420x300.jpg\" class=\"attachment-medium size-medium\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/www.bumc.bu.edu\/ppb\/files\/2013\/10\/Print7a-420x300.jpg 420w, https:\/\/www.bumc.bu.edu\/ppb\/files\/2013\/10\/Print7a-1024x731.jpg 1024w\" sizes=\"(max-width: 420px) 100vw, 420px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='\/ppb\/files\/2013\/10\/Print3.jpg'><img width=\"420\" height=\"300\" src=\"\/ppb\/files\/2013\/10\/Print3-420x300.jpg\" class=\"attachment-medium size-medium\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/www.bumc.bu.edu\/ppb\/files\/2013\/10\/Print3-420x300.jpg 420w, https:\/\/www.bumc.bu.edu\/ppb\/files\/2013\/10\/Print3-1024x731.jpg 1024w\" sizes=\"(max-width: 420px) 100vw, 420px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a href='\/ppb\/files\/2013\/10\/Printc.jpg'><img width=\"283\" height=\"300\" src=\"\/ppb\/files\/2013\/10\/Printc-283x300.jpg\" class=\"attachment-medium size-medium\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/www.bumc.bu.edu\/ppb\/files\/2013\/10\/Printc-283x300.jpg 283w, https:\/\/www.bumc.bu.edu\/ppb\/files\/2013\/10\/Printc-967x1024.jpg 967w\" sizes=\"(max-width: 283px) 100vw, 283px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='\/ppb\/files\/2013\/10\/Croppedmultipolara.jpg'><img width=\"385\" height=\"300\" src=\"\/ppb\/files\/2013\/10\/Croppedmultipolara-385x300.jpg\" class=\"attachment-medium size-medium\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/www.bumc.bu.edu\/ppb\/files\/2013\/10\/Croppedmultipolara-385x300.jpg 385w, https:\/\/www.bumc.bu.edu\/ppb\/files\/2013\/10\/Croppedmultipolara-1024x796.jpg 1024w\" sizes=\"(max-width: 385px) 100vw, 385px\" \/><\/a>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n<\/p>\n<p><\/div>\n<\/div>\n\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h3 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Publications<\/h3><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<p><b>Selected Publications:<\/b><\/p>\n<p><b>Ganem NJ<\/b>*<b>,<\/b> and Pellman D. 2012. Linking abnormal mitosis with the acquisition of DNA damage.\u00a0<i>J Cell Biol.<\/i> 199(6):871-878. PMID: 2329895. PMCID: PMC 3518222\u00a0.\u00a0<i>*Corresponding author<\/i><b><i>.<\/i><\/b><\/p>\n<ul>\n<li>Highlighted in Biobytes Podcast: <a href=\"https:\/\/rupress.org\/jcb\/article\/199\/6\/871\/36973\/Linking-abnormal-mitosis-to-the-acquisition-of-DNA\">https:\/\/rupress.org\/jcb\/article\/199\/6\/871\/36973\/Linking-abnormal-mitosis-to-the-acquisition-of-DNA<\/a><\/li>\n<\/ul>\n<p>Crasta K,\u00a0<b>Ganem NJ<\/b>, Dagher R, Lantermann AB, Ivanova EV, Pan Y, Nezi L, Protopopov A, Chowdhury D, and Pellman D. 2012. Errors in mitosis cause DNA breaks and chromosome pulverization.\u00a0<i>Nature<\/i>. 482(7383):53-58. PMID:22258507. PMCID:PMC 3271137.\u00a0.<\/p>\n<ul>\n<li>Highlighted in Nature Reviews Cancer, \u201cShattered details\u201d Research Highlights, 12:153.<\/li>\n<\/ul>\n<p><b>Ganem NJ<\/b>, Godinho SA, and Pellman D. 2009. A mechanism linking extra centrosomes to chromosome instability.\u00a0<i>Nature.<\/i> 460:278-282.<\/p>\n<ul>\n<li>Highlighted in Nature, \u201cMaking the paper: Neil Ganem\u201d, 460:149; Current Biology, \u201cCancer: CINful Centrosomes\u201d Dispatch, 19(15):642-645; Nature Reviews Cancer, \u201cChromosomal Instability: It\u2019s about the geometry\u201d Research Highlights, 9:529.<\/li>\n<\/ul>\n<p>Kwon M, Godinho SA, Chandhok NS,\u00a0<b>Ganem NJ<\/b>, Azioune A, Thery M, and Pellman D. 2008. Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.\u00a0<i>Genes Dev<\/i><b>.<\/b>22(16):2189-2203.<\/p>\n<ul>\n<li>Highlighted in Cell, \u201cA Tale of too many centrosomes\u201d Minireview, 134(4):572-575; Nature Reviews in Molecular Cell Biology, \u201cCancer Biology: The counting game\u201d Research Highlight, 9:669; Genes and Development, \u201cMultiple Centrosomes: together they stand, divided they fall\u201d Perspective, 22 (17):22911-6; and Cancer Cell, \u201cActin and Microtubules: Working together to control spindle polarity\u201d Preview, 14(3):197-199.<\/li>\n<\/ul>\n<p><b>Ganem NJ<\/b>,\u00a0Storchova Z, and Pellman D. 2007. Tetraploidy, aneuploidy, and cancer.\u00a0<i>Curr Opin Genet Dev.<\/i> 17:157-162.<\/p>\n<p><b>Ganem NJ,<\/b> and Pellman D. 2007. Limiting the proliferation of polyploid cells.\u00a0<i>Cell.<\/i> 131:437-440.<\/p>\n<p>Manning AL*,\u00a0<b>Ganem NJ*<\/b>, Bakhoum SF, Wagenbach M, Wordeman L, and Compton DA. 2007. The kinesin-13 proteins Kif2a, Kif2b, and Kif2c\/MCAK have distinct roles during mitosis in human cells.\u00a0<i>Mol. Biol. Cell.<\/i> 18(8):2970-2979.\u00a0<i>*Co-first authors.<\/i><\/p>\n<p>Couch RD,\u00a0<b>Ganem NJ<\/b>, Zhou M, Popov V, Honda T, Veenstra T, Sporn MB, and Anderson AC. 2005. 2-cyano-3,12-dioxooleana-1,9(11)-diene-28-oic acid (CDDO) disrupts microtubule polymerization: A possible mechanism contributing to apoptosis.\u00a0<i>J Mol Pharm<\/i>. 69:1158-1165.<\/p>\n<p><b>Ganem NJ<\/b>, and Compton DA. 2006. Functional roles of poleward microtubule flux during mitosis.<i>Cell Cycle<\/i><b>.<\/b> 5:481-485.<\/p>\n<p><b>Ganem NJ<\/b>, Upton K, and Compton DA.\u00a0 2005. Efficient mitosis in human cells lacking poleward microtubule flux.\u00a0<i>Curr. Biol.<\/i><b> <\/b>15(20): 1827-1832.<\/p>\n<ul>\n<li>Highlighted in Current Biology<i>,<\/i> \u201cMicrotubule flux: what is it good for?\u201d Dispatch, 15(25):966-968.<\/li>\n<\/ul>\n<p><b>Ganem NJ<\/b>, and Compton DA. 2004. The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK.\u00a0<i>J Cell Biol<\/i><b>.<\/b> 166(4): 473-478.<\/p>\n<p><\/div>\n<\/div>\n\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h3 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Contact<\/h3><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<p><span style=\"color: #000000;\"><strong>Neil J. Ganem, Ph.D.<\/strong><\/span><br \/>\n<span style=\"color: #000000;\">Assistant Professor of Pharmacology and Medicine<\/span><br \/>\n<span style=\"color: #000000;\">72 E. Concord St, K-712c<\/span><br \/>\n<span style=\"color: #000000;\">Boston, MA 02118<\/span><br \/>\n<span style=\"color: #000000;\">Phone: 617-638-5382<\/span><br \/>\n<span style=\"color: #000000;\">Email:<\/span>\u00a0<a href=\"mailto:nganem@bu.edu\">nganem@bu.edu<\/a><\/p>\n<p><span style=\"color: #000000;\"><strong>Laboratory of Cancer Cell Biology:<\/strong><\/span><br \/>\n<span style=\"color: #000000;\">Lab: 72 E. Concord St,\u00a0K-706<\/span><br \/>\n<span style=\"color: #000000;\">Phone: 617-638-5308<\/span><\/p>\n<p><\/div>\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>Research Dr. Neil Ganem\u2019s laboratory uses a combination of high-resolution microscopy, genome-wide RNAi screening, cell biology, and bioinformatics to study the causes and consequences of genome instability in human cancer. Dr. Ganem\u2019s lab seeks to define the tumor suppression mechanisms that \u00a0limit the proliferation of highly abnormal aneuploid cells, as well as to identify the [&hellip;]<\/p>\n","protected":false},"author":1135,"featured_media":0,"parent":1794,"menu_order":12,"comment_status":"closed","ping_status":"closed","template":"page-templates\/no-sidebars.php","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages\/8959"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/users\/1135"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/comments?post=8959"}],"version-history":[{"count":32,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages\/8959\/revisions"}],"predecessor-version":[{"id":19610,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages\/8959\/revisions\/19610"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages\/1794"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/media?parent=8959"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}