{"id":8306,"date":"2013-06-19T11:45:51","date_gmt":"2013-06-19T15:45:51","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/ppb\/?page_id=8306"},"modified":"2023-09-14T08:27:36","modified_gmt":"2023-09-14T12:27:36","slug":"ganem","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/ppb\/people\/faculty\/faculty-profiles\/ganem\/","title":{"rendered":"Neil J. Ganem, Ph.D."},"content":{"rendered":"<p><em><img loading=\"lazy\" class=\"alignleft size-large wp-image-8307\" height=\"258\" width=\"216\" title=\"DSC_0015\" alt=\"DSC_0015\" src=\"\/ppb\/files\/2013\/06\/DSC_0015-857x1024.jpg\" srcset=\"https:\/\/www.bumc.bu.edu\/ppb\/files\/2013\/06\/DSC_0015-857x1024.jpg 857w, https:\/\/www.bumc.bu.edu\/ppb\/files\/2013\/06\/DSC_0015-251x300.jpg 251w, https:\/\/www.bumc.bu.edu\/ppb\/files\/2013\/06\/DSC_0015.jpg 1246w\" sizes=\"(max-width: 216px) 100vw, 216px\" \/><em>Associate Professor of Pharmacology and Medicine, <\/em><\/em>Section of Hematology and Medical Oncology<br \/>\nDepartment of Pharmacology<em><br \/>\n<\/em><\/p>\n<p><em>Ph.D.: <\/em>Dartmouth Medical School<\/p>\n<p><em>Post-Doctoral Fellow: <\/em>Dana-Farber Cancer Institute, Harvard Medical School<\/p>\n<p><a href=\"http:\/\/ganemlab.com\/\" target=\"_blank\" rel=\"noopener noreferrer\"><em>Link to the Official Website of the Ganem Laboratory of Cancer Cell Biology<\/em><\/a><\/p>\n<h3>Research Interests<\/h3>\n<p>Dr. Ganem\u2019s laboratory uses a combination of high-resolution microscopy, genome-wide RNAi screening, cell biology, and bioinformatics to study the causes and consequences of genome instability in human cancer. Dr. Ganem\u2019s lab seeks to define the tumor suppression mechanisms that \u00a0limit the proliferation of highly abnormal aneuploid cells, as well as to identify the common genetic adaptations made by cancer cells to overcome these growth barriers.<\/p>\n<p>Current projects in the lab are aimed at:<\/p>\n<p>1) Identifying the cellular defects that trigger activation of the Hippo tumor suppressor pathway in aneuploid cells.<\/p>\n<p>2) Examining the consequences of oncogenic signaling on mitotic fidelity and chromosome segregation.<\/p>\n<p>3) Characterizing novel regulators of growth factor signaling and the Hippo pathway, as uncovered by a functional RNAi screen.<\/p>\n<p>Dr. Ganem is currently accepting Rotation Students.<\/p>\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h3 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Contact<\/h3><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<p>Office: K-712c<br \/>\nLab: K-706<br \/>\nPhone: 617-358-4678<br \/>\nFax: 617-358-6583<br \/>\nEmail: <a href=\"mailto:nganem@bu.edu\">nganem@bu.edu<\/a><br \/>\n<\/div>\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>Associate Professor of Pharmacology and Medicine, Section of Hematology and Medical Oncology Department of Pharmacology Ph.D.: Dartmouth Medical School Post-Doctoral Fellow: Dana-Farber Cancer Institute, Harvard Medical School Link to the Official Website of the Ganem Laboratory of Cancer Cell Biology Research Interests Dr. Ganem\u2019s laboratory uses a combination of high-resolution microscopy, genome-wide RNAi screening, cell [&hellip;]<\/p>\n","protected":false},"author":6226,"featured_media":0,"parent":1786,"menu_order":10,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages\/8306"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/users\/6226"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/comments?post=8306"}],"version-history":[{"count":39,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages\/8306\/revisions"}],"predecessor-version":[{"id":21656,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages\/8306\/revisions\/21656"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages\/1786"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/media?parent=8306"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}