{"id":22327,"date":"2023-10-20T13:40:37","date_gmt":"2023-10-20T17:40:37","guid":{"rendered":"http:\/\/www.bumc.bu.edu\/ppb\/?page_id=22327"},"modified":"2025-10-09T12:52:50","modified_gmt":"2025-10-09T16:52:50","slug":"pharmacokinetic-and-pharmacodynamic-simulators","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/ppb\/pharmacokinetic-and-pharmacodynamic-simulators\/","title":{"rendered":"Pharmacokinetic and Pharmacodynamic Simulators"},"content":{"rendered":"

\"10-3009-PHARMAHEAD-026_2\"<\/p>\n

The simulators on this page were built by the late Dr. Terrell T. Gibbs to help students gain a conceptual understanding of pharmacokinetics and pharmacodynamics. \u00a0Dr. Gibbs\u00a0played a key role in the design and implementation of the curriculum for the Biomolecular Pharmacology Predoctoral Training Program at Boston University and guided innumerable PhD candidates. \u00a0He taught medical, dental, and master\u2019s degree students at BUSM the principles of pharmacology and the actions of drugs affecting the peripheral and central nervous system. \u00a0 Numerous medical students learned the principles of pharmacodynamics under his tutelage.<\/span><\/p>\n

 <\/p>\n

Pharmacokinetic simulators:<\/strong><\/p>\n

1..Multiple dose 1.1<\/a>\u00a0 This simulator is designed to allow students to experiment with effects dose and dosing interval as well as the effects of individual differences in total clearance and volume of distribution. \u00a0Simulation of Cp vs t for a multiple i.v. dosing regimen: effect of maintenance dose,\u00a0V<\/span>d<\/span>, Cl<\/span>tot<\/span>,\u00a0dosing interval (<\/span>t<\/span>),\u00a0and number of doses.<\/span><\/p>\n

2.\u00a0Infusion kinetics 1.1<\/a>\u00a0 This simulator is designed to allow students to experiment with the effects of changing loading dose, infusion rate, duration as well as the effects of individual differences in total clearance and volume of distribution. \u00a0Simulation of Cp vs t for a continuous iv infusion: effect of infusion rate (ko<\/span>), Vd<\/span>, Cltot<\/span>, infusion time (Tinf<\/span>), and loading dose (L.D.).<\/p>\n

 <\/p>\n

Pharmacodynamic simulators:<\/strong><\/p>\n

1.\u00a0ExploratoryTheorPham1.251<\/a>\u00a0Simulator includes: a) Effects of uncompetitive inhibitor on agonist binding and response; b) Spare receptors and noncompetitive inhibition; c)\u00a0Spare receptors and competitive inhibition; and d)\u00a0Two-state models of receptor activation<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

The simulators on this page were built by the late Dr. Terrell T. Gibbs to help students gain a conceptual understanding of pharmacokinetics and pharmacodynamics. \u00a0Dr. Gibbs\u00a0played a key role in the design and implementation of the curriculum for the Biomolecular Pharmacology Predoctoral Training Program at Boston University and guided innumerable PhD candidates. \u00a0He taught […]<\/p>\n","protected":false},"author":1811,"featured_media":0,"parent":0,"menu_order":30,"comment_status":"closed","ping_status":"closed","template":"page-templates\/no-sidebars.php","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages\/22327"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/users\/1811"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/comments?post=22327"}],"version-history":[{"count":7,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages\/22327\/revisions"}],"predecessor-version":[{"id":24043,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages\/22327\/revisions\/24043"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/media?parent=22327"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}