![\"Sabino\"](\"\/ppb\/files\/2010\/05\/Sabino-188x300.jpg\")
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Professor of Pharmacology and Psychiatry<\/em> Ph.D.: University of Palermo, Palermo, Italy<\/em><\/p>\n Dr. Sabino is co-director of the Laboratory of Addictive Disorders, and is currently researching the neurobiology of addiction and stress-related disorders. Studies on addiction aim to understand the neurobiological substrates of alcohol abuse and dependence by exploring the role of neurochemical systems in excessive alcohol drinking.<\/p>\n Dr. Sabino is working toward the development of new therapeutic agents to alleviate alcohol addiction. Animal models for excessive drinking are studied in order to identify compounds for potential clinical development. Research is also conducted on the neurobiology of stress-related disorders such as anxiety and depression.<\/p>\n The approach of the laboratory is interdisciplinary, involving behavioral neuroscience, neuropharmacology, neuroanatomy, biochemistry and molecular biology.<\/p>\n Dr. Sabino co-directs a graduate course in neuropsychopharmacology offered for the first time in Fall 2010 which examines the interaction between behavior and classes of drugs that affect the central nervous system giving emphasis on how behavioral studies can assist in our understanding of mental disorders.<\/p>\n <\/div>\n<\/div>\n\n
\nDepartment of Pharmacology<\/p>\n![\"LAD](\"\/ppb\/files\/2010\/05\/LAD_logo2.jpg\"){kind=logo}
\n<\/a>(click for lab site)<\/p>\nResearch Interests<\/h3>\n
Recent News<\/h3>
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Selected Publications<\/h3>
<\/p>\nSabino V<\/span><\/span><\/span><\/span><\/span><\/span>, Blasio A, Ferragud A, Quadir SG, Iyer MR, Rice KC, Cottone P<\/span><\/span><\/span><\/span><\/span>. Characterization of a differential reinforcement of low rates of responding task in non-deprived male and female rats: Role of Sigma-1 receptors. Neuropharmacology<\/em>. 2021 12 01; 200:108786.View Related Profiles<\/a>.\u00a0<\/span>PMID:\u00a0<\/span>34516984<\/a><\/span><\/div>\n<\/div>\nQuadir SG, Tanino SM, Sami YN, Minnig MA, Iyer MR, Rice KC, Cottone P, Sabino V<\/span><\/span><\/span><\/span><\/span>. Antagonism of Sigma-1 receptor blocks heavy alcohol drinking and associated hyperalgesia in male mice. Alcohol Clin Exp Res.<\/em> 2021 07; 45(7):1398-1407.View Related Profiles<\/a>.\u00a0<\/span>PMID:\u00a0<\/span>34060104<\/a>; DOI:\u00a0<\/span>10.1111\/acer.14635<\/a>;<\/span><\/div>\n<\/div>\nQuadir SG, Tanino SM, Rohl CD, Sahn JJ, Yao EJ, Cruz LDR, Cottone P<\/span><\/span><\/span><\/span><\/span>, Martin SF, Sabino V<\/span><\/span><\/span><\/span><\/span><\/span>. The Sigma-2 receptor \/ transmembrane protein 97 (s2R\/TMEM97) modulator JVW-1034 reduces heavy alcohol drinking and associated pain states in male mice. Neuropharmacology<\/em>. 2021 02 15; 184:108409.View Related Profiles<\/a>.\u00a0<\/span>PMID:\u00a0<\/span>33221481<\/a>; DOI:\u00a0<\/span>10.1016\/j.neuropharm.2020.108409<\/a>;<\/span><\/div>\n<\/div>\nFerragud A, Velazquez-Sanchez C, Minnig MA, Sabino V<\/span><\/span><\/span><\/span><\/span><\/span>, Cottone P<\/span><\/span><\/span><\/span><\/span><\/span>. Pituitary adenylate cyclase-activating polypeptide (PACAP) modulates dependence-induced alcohol drinking and anxiety-like behavior in male rats. Neuropsychopharmacology<\/em>. 2021 02; 46(3):509-518.View Related Profiles<\/a>.\u00a0<\/span>PMID:\u00a0<\/span>33191400<\/a>; DOI:\u00a0<\/span>10.1038\/s41386-020-00904-4<\/a>;<\/span><\/div>\n<\/div>\nLee HS, Giunti E, Sabino V<\/span><\/span><\/span><\/span><\/span><\/span><\/span>, Cottone P<\/span><\/span><\/span><\/span><\/span><\/span>. Consummatory, Feeding Microstructural, and Metabolic Effects Induced by Limiting Access to Either a High-Sucrose or a High-Fat Diet. Nutrients<\/em>. 2020 May 30; 12(6).View Related Profiles<\/a>.\u00a0<\/span>PMID:\u00a0<\/span>32486207<\/a>; DOI:\u00a0<\/span>10.3390\/nu12061610<\/a>;<\/span><\/div>\n<\/div>\nHicks C, Sabino V<\/span><\/span><\/span><\/span><\/span><\/span><\/span>, Cottone P<\/span><\/span><\/span><\/span><\/span><\/span><\/span>. The Alpha-1 Adrenergic Receptor Antagonist Prazosin Reduces Binge-Like Eating in Rats. Nutrients<\/em>. 2020 May 28; 12(6).View Related Profiles<\/a>.\u00a0<\/span>PMID:\u00a0<\/span>32481494<\/a>; DOI:\u00a0<\/span>10.3390\/nu12061569<\/a>;<\/span><\/div>\n<\/div>\nFerragud A, Vel\u00e1zquez-S\u00e1nchez C, Abdullatif AA, Sabino V<\/span><\/span><\/span><\/span><\/span><\/span><\/span>, Cottone P<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span>. Withdrawal from Extended, Intermittent Access to A Highly Palatable Diet Impairs Hippocampal Memory Function and Neurogenesis: Effects of Memantine. Nutrients<\/em>. 2020 May 23; 12(5).View Related Profiles<\/a>.\u00a0<\/span>PMID:\u00a0<\/span>32456193<\/a>; DOI:\u00a0<\/span>10.3390\/nu12051520<\/a>;<\/span><\/div>\n<\/div>\nQuadir SG, Rohl CD, Zeabi A, Moore CF, Cottone P, Sabino V<\/span><\/span><\/span><\/span><\/span>. Effect of different standard rodent diets on ethanol intake and associated allodynia in male mice. Alcohol<\/em>. 2020 09; 87:17-23.View Related Profiles<\/a>.\u00a0<\/span>PMID:\u00a0<\/span>32330590<\/a>; DOI:\u00a0<\/span>10.1016\/j.alcohol.2020.04.003<\/a>;<\/span><\/div>\n<\/div>\nValenza M, Blasio A, DiLeo A, Cottone P, Sabino V<\/span><\/span><\/span><\/span><\/span>. Sigma receptor-induced heavy drinking in rats: Modulation by the opioid receptor system. Pharmacol Biochem Behav.<\/em> 2020 05; 192:172914.View Related Profiles<\/a>.\u00a0<\/span>PMID:\u00a0<\/span>32205151<\/a><\/span><\/div>\n<\/div>\nMoore CF, Leonard MZ, Micovic NM, Miczek KA, Sabino V<\/span>, Cottone P<\/span><\/span><\/span><\/span><\/span>. Reward sensitivity deficits in a rat model of compulsive eating behavior. Neuropsychopharmacology<\/em>. 2020 03; 45(4):589-596.View Related Profiles<\/a>.\u00a0<\/span>PMID:\u00a0<\/span>31622973<\/a>; DOI:\u00a0<\/span>10.1038\/s41386-019-0550-1<\/a>;<\/span><\/div>\n\n<\/div>\nSeiglie MP, Huang L, Cottone P, Sabino V<\/span><\/span><\/span><\/span>. Role of the PACAP system of the extended amygdala in the acoustic startle response in rats. Neuropharmacology<\/em>. 2019 12 01; 160:107761.View Related Profiles<\/a>.\u00a0<\/span>PMID:\u00a0<\/span>31493466<\/a>; DOI:\u00a0<\/span>10.1016\/j.neuropharm.2019.107761<\/a>;<\/span><\/div>\n<\/div>\n