{"id":1421,"date":"2010-05-18T17:17:42","date_gmt":"2010-05-18T21:17:42","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/ppb\/?page_id=1421"},"modified":"2025-10-01T13:05:58","modified_gmt":"2025-10-01T17:05:58","slug":"cottone","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/ppb\/people\/faculty\/faculty-profiles\/cottone\/","title":{"rendered":"Pietro Cottone, Ph.D."},"content":{"rendered":"<p><a href=\"\/ppb\/files\/2010\/05\/Cottone-323x300.jpeg\"><img loading=\"lazy\" class=\"alignleft size-full wp-image-7484\" title=\"Cottone-323x300\" alt=\"Cottone-323x300\" src=\"\/ppb\/files\/2010\/05\/Cottone-323x300.jpeg\" width=\"241\" height=\"300\" \/><\/a><\/p>\n<p><em>Associate Professor of Pharmacology and Psychiatry<\/em><br \/>\nDepartment of Pharmacology<\/p>\n<p><em>Ph.D.: University of Rome La Sapienza, Rome, Italy<\/em><\/p>\n<p><a href=\"https:\/\/www.bumc.bu.edu\/ppb\/training-program\/laboratories\/lad\/\" title=\"LAD\"><img loading=\"lazy\" alt=\"LAD - Laboratory of Addictive Disorders\" src=\"\/ppb\/files\/2010\/05\/LAD_logo2.jpg\" class=\"alignnone size-full wp-image-1435\" width=\"203\" height=\"100\" \/><br \/>\n<\/a>(click for lab site)<\/p>\n<h3>Research Interests<\/h3>\n<p style=\"text-align: justify;\">Dr. Cottone is co-director of the Laboratory of Addictive Disorders. Dr. Cottone\u2019s research interests focus on the neurobiological substrates of motivated behaviors including feeding and addiction. The major goal of Dr. Cottone\u2019s research is identifying the biological bases of and potential treatments for eating disorders and obesity. Current studies concern the role of stress in compulsive eating and palatable food dependence. Areas of focused research include the investigation of the neurobiological bases of stress-related disorders such as anxiety and depression. Dr. Cottone\u2019s studies are carried out on environmental and genetic animal models, using behavioral, biochemical, and molecular approaches.<\/p>\n<p style=\"text-align: justify;\">Dr. Cottone co-directs a graduate course in neuropsychopharmacology offered for the first time in Fall 2010 which examines the interaction between behavior and classes of drugs that affect the central nervous system.<\/p>\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h3 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Recent News<\/h3><div class=\"bu_collapsible_section\" style=\"display: none;\"><strong><\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/www.bumc.bu.edu\/ppb\/2019\/08\/14\/drs-pietro-cottone-and-valentina-sabino-become-u-s-citizens-dr-cottone-records-album-shares-perspective-in-the-boston-globe-and-bu-today\/\">Drs. Pietro Cottone and Valentina Sabino become U.S. citizens. Dr. Cottone Records Album\/Shares Perspective in the Boston Globe and BU Today.<\/a><\/li>\n<li><a href=\"https:\/\/www.bumc.bu.edu\/ppb\/2017\/06\/21\/dr-pietro-cottone-speaks-at-the-royal-societys-of-mice-and-mental-health-facilitating-dialogue-between-basic-and-clinical-neuroscientists\/\">Neurobiology of Compulsive Eating <\/a>Presentation at The Royal Society&#8217;s &#8220;Of mice and mental health: facilitating dialogue between basic and clinical neuroscientists.&#8221;<\/li>\n<\/ul>\n<ul>\n<li>PsychCentral. New\u00a0Pharmacological Approach for\u00a0Binge Eating. <a href=\"https:\/\/www.bumc.bu.edu\/ppb\/2016\/10\/07\/the-laboratory-of-addictive-disorders-identifies-new-approach-to-block-binge-eating\/\">Laboratory of Addictive Disorders <\/a>identify new therapeutic approach.<\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.bumc.bu.edu\/busm\/2014\/05\/05\/study-shows-that-impulsivity-is-risk-factor-for-food-addiction\/\">Boston University School of Medicine<\/a>. Researchers\u00a0in the Laboratory of Addictive Disorders have discovered that impulsivity is a risk factor for food addiction . Results of the study, published online in\u00a0<em>Neuropsychopharmacology\u00a0<\/em><a href=\"http:\/\/www.nature.com\/npp\/journal\/vaop\/naam\/abs\/npp201498a.html\" title=\"High Trait Impulsivity Predicts Food Addiction-Like Behavior in the Rat\" target=\"_blank\" rel=\"noopener noreferrer\"><\/a>, suggest that impulsivity promotes pathological overeating.<\/li>\n<\/ul>\n<ul>\n<li><a href=\" http:\/\/www.sciencedaily.com\/releases\/2014\/05\/140506142157.htm\">Sciencedaily<\/a>: Impulsivity is a risk factor for food addition.<\/li>\n<\/ul>\n<ul>\n<li><a href=\"http:\/\/www.huffingtonpost.com\/2014\/05\/13\/impulsive-behavior-food-addiction_n_5312094.html\">Huffington Post<\/a>: Could Impulsive Behavior Lead to Food Addiction?<\/li>\n<\/ul>\n<ul>\n<li><a href=\"https:\/\/www.bumc.bu.edu\/ppb\/2012\/10\/19\/angelo-blasio-presents-at-annual-sfn-meeting-addiction-drug-could-curb-binge-eating\/\" target=\"_blank\" rel=\"noopener noreferrer\">The Laboratory of Addictive Disorders in the news at SfN<\/a><\/li>\n<\/ul>\n<p><\/div>\n<\/div>\n\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h3 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Selected Peer-Reviewed Publications<\/h3><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublication_ctl01_lblPublication\">Valentina S, Blasio A, Ferragud A, Quadir SG, Iyer MR, Rice KC, <span style=\"text-decoration: underline;\">Cottone P<\/span>. Characterization of a differential reinforcement of low rates of responding task in non-deprived male and female rats: Role of Sigma-1 receptors. <em>Neuropharmacology<\/em>. 2021 12 01; 200:108786.<a data-target=\"#related_profiles_34516984\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/34516984\" target=\"_blank\" rel=\"noopener noreferrer\">34516984<\/a><\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublication_ctl02_lblPublication\">Quadir SG, Tanino SM, Sami YN, Minnig MA, Iyer MR, Rice KC, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Sabino V. Antagonism of Sigma-1 receptor blocks heavy alcohol drinking and associated hyperalgesia in male mice. <em>Alcohol Clin Exp Res.<\/em> 2021 07; 45(7):1398-1407.<a data-target=\"#related_profiles_34060104\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/34060104\" target=\"_blank\" rel=\"noopener noreferrer\">34060104<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1111\/acer.14635\" target=\"_blank\" rel=\"noopener noreferrer\">10.1111\/acer.14635<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublication_ctl03_lblPublication\">Quadir SG, Tanino SM, Rohl CD, Sahn JJ, Yao EJ, Cruz LDR, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Martin SF, Sabino V. The Sigma-2 receptor \/ transmembrane protein 97 (s2R\/TMEM97) modulator JVW-1034 reduces heavy alcohol drinking and associated pain states in male mice. <em>Neuropharmacology<\/em>. 2021 02 15; 184:108409.<a data-target=\"#related_profiles_33221481\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/33221481\" target=\"_blank\" rel=\"noopener noreferrer\">33221481<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1016\/j.neuropharm.2020.108409\" target=\"_blank\" rel=\"noopener noreferrer\">10.1016\/j.neuropharm.2020.108409<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublication_ctl04_lblPublication\">Ferragud A, Velazquez-Sanchez C, Minnig MA, Sabino V, <span style=\"text-decoration: underline;\">Cottone P<\/span>. Pituitary adenylate cyclase-activating polypeptide (PACAP) modulates dependence-induced alcohol drinking and anxiety-like behavior in male rats. <em>Neuropsychopharmacology<\/em>. 2021 02; 46(3):509-518.<a data-target=\"#related_profiles_33191400\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/33191400\" target=\"_blank\" rel=\"noopener noreferrer\">33191400<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1038\/s41386-020-00904-4\" target=\"_blank\" rel=\"noopener noreferrer\">10.1038\/s41386-020-00904-4<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublication_ctl05_lblPublication\">Lee HS, Giunti E, Sabino V, <span style=\"text-decoration: underline;\">Cottone P<\/span>. Consummatory, Feeding Microstructural, and Metabolic Effects Induced by Limiting Access to Either a High-Sucrose or a High-Fat Diet. <em>Nutrients<\/em>. 2020 May 30; 12(6).<a data-target=\"#related_profiles_32486207\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32486207\" target=\"_blank\" rel=\"noopener noreferrer\">32486207<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.3390\/nu12061610\" target=\"_blank\" rel=\"noopener noreferrer\">10.3390\/nu12061610<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublication_ctl06_lblPublication\">Hicks C, Sabino V, <span style=\"text-decoration: underline;\">Cottone P<\/span>. The Alpha-1 Adrenergic Receptor Antagonist Prazosin Reduces Binge-Like Eating in Rats. <em>Nutrients<\/em>. 2020 May 28; 12(6).<a data-target=\"#related_profiles_32481494\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32481494\" target=\"_blank\" rel=\"noopener noreferrer\">32481494<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.3390\/nu12061569\" target=\"_blank\" rel=\"noopener noreferrer\">10.3390\/nu12061569<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublication_ctl07_lblPublication\">Ferragud A, Vel\u00e1zquez-S\u00e1nchez C, Abdullatif AA, Sabino V, <span style=\"text-decoration: underline;\">Cottone P<\/span>. Withdrawal from Extended, Intermittent Access to A Highly Palatable Diet Impairs Hippocampal Memory Function and Neurogenesis: Effects of Memantine. <em>Nutrients<\/em>. 2020 May 23; 12(5).<a data-target=\"#related_profiles_32456193\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32456193\" target=\"_blank\" rel=\"noopener noreferrer\">32456193<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.3390\/nu12051520\" target=\"_blank\" rel=\"noopener noreferrer\">10.3390\/nu12051520<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublication_ctl08_lblPublication\">Quadir SG, Rohl CD, Zeabi A, Moore CF, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Sabino V. Effect of different standard rodent diets on ethanol intake and associated allodynia in male mice. <em>Alcohol<\/em>. 2020 09; 87:17-23.<a data-target=\"#related_profiles_32330590\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32330590\" target=\"_blank\" rel=\"noopener noreferrer\">32330590<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1016\/j.alcohol.2020.04.003\" target=\"_blank\" rel=\"noopener noreferrer\">10.1016\/j.alcohol.2020.04.003<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublication_ctl09_lblPublication\">Valenza M, Blasio A, DiLeo A, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Sabino V. Sigma receptor-induced heavy drinking in rats: Modulation by the opioid receptor system. <em>Pharmacol Biochem Behav.<\/em> 2020 05; 192:172914.<a data-target=\"#related_profiles_32205151\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32205151\" target=\"_blank\" rel=\"noopener noreferrer\">32205151<\/a><\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublication_ctl10_lblPublication\">Moore CF, Leonard MZ, Micovic NM, Miczek KA, Sabino V, <span style=\"text-decoration: underline;\">Cottone P<\/span>. Reward sensitivity deficits in a rat model of compulsive eating behavior. <em>Neuropsychopharmacology<\/em>. 2020 03; 45(4):589-596.<a data-target=\"#related_profiles_31622973\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31622973\" target=\"_blank\" rel=\"noopener noreferrer\">31622973<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1038\/s41386-019-0550-1\" target=\"_blank\" rel=\"noopener noreferrer\">10.1038\/s41386-019-0550-1<\/a>;<\/span><\/div>\n<div id=\"div_publications_more\">\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl01_lblPublication\">Seiglie MP, Huang L, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Sabino V. Role of the PACAP system of the extended amygdala in the acoustic startle response in rats. <em>Neuropharmacology<\/em>. 2019 12 01; 160:107761.<a data-target=\"#related_profiles_31493466\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31493466\" target=\"_blank\" rel=\"noopener noreferrer\">31493466<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1016\/j.neuropharm.2019.107761\" target=\"_blank\" rel=\"noopener noreferrer\">10.1016\/j.neuropharm.2019.107761<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl02_lblPublication\">Quadir SG, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Sabino V. Role of Sigma Receptors in Alcohol Addiction. <em>Front Pharmacol.<\/em> 2019; 10:687.<a data-target=\"#related_profiles_31258483\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31258483\" target=\"_blank\" rel=\"noopener noreferrer\">31258483<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.3389\/fphar.2019.00687\" target=\"_blank\" rel=\"noopener noreferrer\">10.3389\/fphar.2019.00687<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl03_lblPublication\">Moore CF, Blasio A, Sabino V, <span style=\"text-decoration: underline;\">Cottone P<\/span>. Impulsive choice does not predict binge-like eating in rats. <em>Behav Pharmacol.<\/em> 2018 12; 29(8):726-731.<a data-target=\"#related_profiles_30325787\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30325787\" target=\"_blank\" rel=\"noopener noreferrer\">30325787<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1097\/FBP.0000000000000446\" target=\"_blank\" rel=\"noopener noreferrer\">10.1097\/FBP.0000000000000446<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl04_lblPublication\">Moore CF, Panciera JI, Sabino V, <span style=\"text-decoration: underline;\">Cottone P<\/span>. Neuropharmacology of compulsive eating. <em>Philos Trans R Soc Lond B Biol Sci.<\/em> 2018 03 19; 373(1742).<a data-target=\"#related_profiles_29352024\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29352024\" target=\"_blank\" rel=\"noopener noreferrer\">29352024<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1098\/rstb.2017.0024\" target=\"_blank\" rel=\"noopener noreferrer\">10.1098\/rstb.2017.0024<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl05_lblPublication\">Moore CF, Sabino V, <span style=\"text-decoration: underline;\">Cottone P<\/span>. Trace Amine Associated Receptor 1 (TAAR1) Modulation of Food Reward. <em>Front Pharmacol.<\/em> 2018; 9:129.<a data-target=\"#related_profiles_29535626\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29535626\" target=\"_blank\" rel=\"noopener noreferrer\">29535626<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.3389\/fphar.2018.00129\" target=\"_blank\" rel=\"noopener noreferrer\">10.3389\/fphar.2018.00129<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl06_lblPublication\">Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, Ferragud A, Botelho E, Ballance HI, Dhawan U, Boudeau S, Cruz AL, Kashy D, Wong A, Goldberg LR, Yazdani N, Zhang C, Ung CY, Tripodis Y, Kanaan NM, Ikezu T, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Leszyk J, Li H, Luebke J, Bryant CD, Wolozin B. Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. <em>Nat Neurosci.<\/em> 2018 01; 21(1):72-80.<a data-target=\"#related_profiles_29273772\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29273772\" target=\"_blank\" rel=\"noopener noreferrer\">29273772<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1038\/s41593-017-0022-z\" target=\"_blank\" rel=\"noopener noreferrer\">10.1038\/s41593-017-0022-z<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl07_lblPublication\">Moore CF, Schlain GS, Mancino S, Sabino V, <span style=\"text-decoration: underline;\">Cottone P<\/span>. A behavioral and pharmacological characterization of palatable diet alternation in mice. <em>Pharmacol Biochem Behav.<\/em> 2017 Dec; 163:1-8.<a data-target=\"#related_profiles_29097161\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29097161\" target=\"_blank\" rel=\"noopener noreferrer\">29097161<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1016\/j.pbb.2017.10.013\" target=\"_blank\" rel=\"noopener noreferrer\">10.1016\/j.pbb.2017.10.013<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl08_lblPublication\">Moore CF, Sabino V, Koob GF, <span style=\"text-decoration: underline;\">Cottone P<\/span>. Neuroscience of Compulsive Eating Behavior. <em>Front Neurosci.<\/em> 2017; 11:469.<a data-target=\"#related_profiles_28883784\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28883784\" target=\"_blank\" rel=\"noopener noreferrer\">28883784<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.3389\/fnins.2017.00469\" target=\"_blank\" rel=\"noopener noreferrer\">10.3389\/fnins.2017.00469<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl09_lblPublication\">Sabino V, Hicks C, <span style=\"text-decoration: underline;\">Cottone P<\/span>. Sigma Receptors and Substance Use Disorders. <em>Adv Exp Med Biol.<\/em> 2017; 964:177-199.<a data-target=\"#related_profiles_28315272\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28315272\" target=\"_blank\" rel=\"noopener noreferrer\">28315272<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1007\/978-3-319-50174-1_13\" target=\"_blank\" rel=\"noopener noreferrer\">10.1007\/978-3-319-50174-1_13<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl10_lblPublication\">Sabino V, <span style=\"text-decoration: underline;\">Cottone P<\/span>. Sigma Receptors and Alcohol Use Disorders. <em>Handb Exp Pharmacol.<\/em> 2017; 244:219-236.<a data-target=\"#related_profiles_28039543\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28039543\" target=\"_blank\" rel=\"noopener noreferrer\">28039543<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1007\/164_2016_97\" target=\"_blank\" rel=\"noopener noreferrer\">10.1007\/164_2016_97<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl11_lblPublication\">Moore CF, Sabino V, Koob GF, <span style=\"text-decoration: underline;\">Cottone P<\/span>. Pathological Overeating: Emerging Evidence for a Compulsivity Construct. <em>Neuropsychopharmacology.<\/em> 2017 Jun; 42(7):1375-1389.<a data-target=\"#related_profiles_27922596\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27922596\" target=\"_blank\" rel=\"noopener noreferrer\">27922596<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1038\/npp.2016.269\" target=\"_blank\" rel=\"noopener noreferrer\">10.1038\/npp.2016.269<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl12_lblPublication\">Kirkpatrick SL, Goldberg LR, Yazdani N, Babbs RK, Wu J, Reed ER, Jenkins DF, Bolgioni AF, Landaverde KI, Luttik KP, Mitchell KS, Kumar V, Johnson WE, Mulligan MK, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Bryant CD. Cytoplasmic FMR1-Interacting Protein 2 Is a Major Genetic Factor Underlying Binge Eating. <em>Biol Psychiatry.<\/em> 2017 May 01; 81(9):757-769.<a data-target=\"#related_profiles_27914629\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27914629\" target=\"_blank\" rel=\"noopener noreferrer\">27914629<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1016\/j.biopsych.2016.10.021\" target=\"_blank\" rel=\"noopener noreferrer\">10.1016\/j.biopsych.2016.10.021<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl13_lblPublication\">Ferragud A, Howell AD, Moore CF, Ta TL, Hoener MC, Sabino V, Cottone P. The Trace Amine-Associated Receptor 1 Agonist RO5256390 Blocks Compulsive, Binge-like Eating in Rats. Neuropsychopharmacology. 2017 Jun; 42(7):1458-1470.<a data-target=\"#related_profiles_27711047\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27711047\" target=\"_blank\" rel=\"noopener noreferrer\">27711047<\/a>; <\/span><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl14_lblPublication\">Iemolo A, Seiglie M, Blasio A, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Sabino V. Pituitary adenylate cyclase-activating polypeptide (PACAP) in the central nucleus of the amygdala induces anxiety via melanocortin receptors. <em>Psychopharmacology<\/em> (Berl). 2016 Sep; 233(17):3269-77.<a data-target=\"#related_profiles_27376948\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27376948\" target=\"_blank\" rel=\"noopener noreferrer\">27376948<\/a>; PMCID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4982769\" target=\"_blank\" rel=\"noopener noreferrer\">PMC4982769<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1007\/s00213-016-4366-y\" target=\"_blank\" rel=\"noopener noreferrer\">10.1007\/s00213-016-4366-y<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl15_lblPublication\">Giuliano C, <span style=\"text-decoration: underline;\">Cottone P<\/span>. The role of the opioid system in binge eating disorder. <em>CNS Spectr.<\/em> 2015 Dec; 20(6):537-45. PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26499083\" target=\"_blank\" rel=\"noopener noreferrer\">26499083<\/a>; PMCID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4831059\" target=\"_blank\" rel=\"noopener noreferrer\">PMC4831059<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1017\/S1092852915000668\" target=\"_blank\" rel=\"noopener noreferrer\">10.1017\/S1092852915000668<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl16_lblPublication\">Valenza M, DiLeo A, Steardo L, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Sabino V. Ethanol-related behaviors in mice lacking the sigma-1 receptor. <em>Behav Brain Res.<\/em> 2016 Jan 15; 297:196-203.<a data-target=\"#related_profiles_26462569\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26462569\" target=\"_blank\" rel=\"noopener noreferrer\">26462569<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1016\/j.bbr.2015.10.013\" target=\"_blank\" rel=\"noopener noreferrer\">10.1016\/j.bbr.2015.10.013<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl17_lblPublication\">Seiglie MP, Smith KL, Blasio A, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Sabino V. Pituitary adenylate cyclase-activating polypeptide induces a depressive-like phenotype in rats. <em>Psychopharmacology<\/em> (Berl). 2015 Oct; 232(20):3821-31.<a data-target=\"#related_profiles_26264905\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26264905\" target=\"_blank\" rel=\"noopener noreferrer\">26264905<\/a>; PMCID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4565740\" target=\"_blank\" rel=\"noopener noreferrer\">PMC4565740<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1007\/s00213-015-4045-4\" target=\"_blank\" rel=\"noopener noreferrer\">10.1007\/s00213-015-4045-4<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl18_lblPublication\">Valenza M, Steardo L, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Sabino V. Diet-induced obesity and diet-resistant rats: differences in the rewarding and anorectic effects of D-amphetamine. <em>Psychopharmacology<\/em> (Berl). 2015 Sep; 232(17):3215-26.<a data-target=\"#related_profiles_26047964\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26047964\" target=\"_blank\" rel=\"noopener noreferrer\">26047964<\/a>; PMCID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4536171\" target=\"_blank\" rel=\"noopener noreferrer\">PMC4536171<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1007\/s00213-015-3981-3\" target=\"_blank\" rel=\"noopener noreferrer\">10.1007\/s00213-015-3981-3<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl19_lblPublication\">Blasio A, Valenza M, Iyer MR, Rice KC, Steardo L, Hayashi T, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Sabino V. Sigma-1 receptor mediates acquisition of alcohol drinking and seeking behavior in alcohol-preferring rats. <em>Behav Brain Res.<\/em> 2015; 287:315-22.<a data-target=\"#related_profiles_25848705\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25848705\" target=\"_blank\" rel=\"noopener noreferrer\">25848705<\/a>; PMCID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4424067\" target=\"_blank\" rel=\"noopener noreferrer\">PMC4424067<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1016\/j.bbr.2015.03.065\" target=\"_blank\" rel=\"noopener noreferrer\">10.1016\/j.bbr.2015.03.065<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl20_lblPublication\">Vel\u00e1zquez-S\u00e1nchez C, Santos JW, Smith KL, Ferragud A, Sabino V, <span style=\"text-decoration: underline;\">Cottone P<\/span>. Seeking behavior, place conditioning, and resistance to conditioned suppression of feeding in rats intermittently exposed to palatable food. <em>Behav Neurosci.<\/em> 2015 Apr; 129(2):219-24.<a data-target=\"#related_profiles_25798634\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25798634\" target=\"_blank\" rel=\"noopener noreferrer\">25798634<\/a>; PMCID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4456453\" target=\"_blank\" rel=\"noopener noreferrer\">PMC4456453<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1037\/bne0000042\" target=\"_blank\" rel=\"noopener noreferrer\">10.1037\/bne0000042<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl21_lblPublication\">Smith KL, Rao RR, Vel\u00e1zquez-S\u00e1nchez C, Valenza M, Giuliano C, Everitt BJ, Sabino V, <span style=\"text-decoration: underline;\">Cottone P<\/span>. The uncompetitive N-methyl-D-aspartate antagonist memantine reduces binge-like eating, food-seeking behavior, and compulsive eating: role of the nucleus accumbens shell. <em>Neuropsychopharmacology<\/em>. 2015 Apr; 40(5):1163-71.<a data-target=\"#related_profiles_25381776\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25381776\" target=\"_blank\" rel=\"noopener noreferrer\">25381776<\/a>; PMCID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4367459\" target=\"_blank\" rel=\"noopener noreferrer\">PMC4367459<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1038\/npp.2014.299\" target=\"_blank\" rel=\"noopener noreferrer\">10.1038\/npp.2014.299<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl22_lblPublication\">Iemolo A, Ferragud A, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Sabino V. Pituitary Adenylate Cyclase-Activating Peptide in the Central Amygdala Causes Anorexia and Body Weight Loss via the Melanocortin and the TrkB Systems. <em>Neuropsychopharmacology<\/em>. 2015 Jul; 40(8):1846-55.<a data-target=\"#related_profiles_25649277\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25649277\" target=\"_blank\" rel=\"noopener noreferrer\">25649277<\/a>; PMCID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4839508\" target=\"_blank\" rel=\"noopener noreferrer\">PMC4839508<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1038\/npp.2015.34\" target=\"_blank\" rel=\"noopener noreferrer\">10.1038\/npp.2015.34<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl23_lblPublication\">Blasio A, Rice KC, Sabino V, <span style=\"text-decoration: underline;\">Cottone P<\/span>. Characterization of a shortened model of diet alternation in female rats: effects of the CB1 receptor antagonist rimonabant on food intake and anxiety-like behavior. <em>Behav Pharmacol.<\/em> 2014 Oct; 25(7):609-17.<a data-target=\"#related_profiles_25011007\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25011007\" target=\"_blank\" rel=\"noopener noreferrer\">25011007<\/a>; PMCID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4149852\" target=\"_blank\" rel=\"noopener noreferrer\">PMC4149852<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1097\/FBP.0000000000000059\" target=\"_blank\" rel=\"noopener noreferrer\">10.1097\/FBP.0000000000000059<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl24_lblPublication\">Vel\u00e1zquez-S\u00e1nchez C, Ferragud T, Moore CF, Everitt BJ, Sabino V, <span style=\"text-decoration: underline;\">Cottone P<\/span>. High trait impulsivity predicts food Addiction-like behavior in the rat. <em>Neuropsychopharmacol<\/em>. 2014.<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl25_lblPublication\">Vel\u00e1zquez-S\u00e1nchez C, Ferragud A, Moore CF, Everitt BJ, Sabino V, <span style=\"text-decoration: underline;\">Cottone P<\/span>. High trait impulsivity predicts food addiction-like behavior in the rat. <em>Neuropsychopharmacology<\/em>. 2014 Sep; 39(10):2463-72.<a data-target=\"#related_profiles_24776685\" data-toggle=\"collapse\">View Related Profiles<\/a>.<span>\u00a0<\/span>PMID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24776685\" target=\"_blank\" rel=\"noopener noreferrer\">24776685<\/a>; PMCID:<span>\u00a0<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4138758\" target=\"_blank\" rel=\"noopener noreferrer\">PMC4138758<\/a>; DOI:<span>\u00a0<\/span><a href=\"http:\/\/dx.doi.org\/10.1038\/npp.2014.98\" target=\"_blank\" rel=\"noopener noreferrer\">10.1038\/npp.2014.98<\/a>;<\/span><\/div>\n<div><\/div>\n<div class=\"publication\"><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl25_lblPublication\"><\/span><span id=\"ctl00_rptMainTabbed_ctl04_ctl00_rpPublicationMore_ctl26_lblPublication\">Blasio A, Rice KC, Sabino V, <span style=\"text-decoration: underline;\">Cottone P<\/span>. Characterization of a shortened model of diet alternation in female rats: effects of the CB1 receptor antagonist rimonabant on food intake and anxiety-like behavior. <em>Behav Pharmacol<\/em> \u201cSpecial Issue on Behavioural Pharmacology of Stress&#8221;. 2014.<\/span><\/div>\n<\/div>\n<p>Blasio A, Iemolo A, Sabino V, Petrosino S, Steardo L, Rice KC, Orlando P, Arturo Iannotti F, Di Marzo V, Zorrilla EP, <span style=\"text-decoration: underline;\">Cottone P<\/span>. Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdale. <em>Neuropsycholpharmacology<\/em>. 2013 Jun 24. Epub ahead of print<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23793355\" target=\"_blank\" rel=\"noopener noreferrer\"><\/a>.<\/p>\n<p><span style=\"text-decoration: underline;\">Cottone P<\/span>, Wang X, Park JW, Valenza M, Blasio A, Kwak J, Iyer MR, Steardo L, Rice KC, Hayashi T, Sabino V. Antagonism of Sigma-1 Receptors Blocks Compulsive-Like Eating. <em> Neuropsychopharmacology. <\/em> 2012 Jun 20 [Epub ahead of print.] <a target=\"_blank\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22713906\" rel=\"noopener noreferrer\"><\/a>.<\/p>\n<p>Blasio A, Narayan AR, Kaminski BJ, Steardo L, Sabino V, <span style=\"text-decoration: underline;\">Cottone P<\/span>. A modified adjusting delay task to assess implusive choice between isocaloric reinforcers in non-deprived male rats: effects of 5-HT2A\/C and 5-HT1A receptor agonists. <em> Psychopharmacology (Berl). <\/em> 2012 Jan; 219(2):377-86. <a target=\"_blank\" href=\"http:\/\/www.springerlink.com\/content\/b2r3586qt53016r3\/\" rel=\"noopener noreferrer\"><\/a>.<\/p>\n<p>Fekete EM, Zhao Y, Sz\u00fccs A, Sabino V, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Rivier J, Vale WW, Koob GF, Zorrilla EP. Systemic urocotrin 2, but not urocortin 1 or stressin 1-A, suppresses feeding via CRF2 receptors without malaise and stress. <em>Br J Pharmacol.<\/em> 2011 Dec; 164(8):1959-75. <a target=\"_blank\" href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1476-5381.2011.01512.x\/full\" rel=\"noopener noreferrer\"><\/a>.<\/p>\n<p>Sabino V, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Blasio A, Iyer MR, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP. Activation of\u00a0\u03c3-receptor induces binge-like drinking in Sardinian alcohol-preferring rats. <em>Neuropsychopharmacology. <\/em> 2011 May; 36(6):1207-18. PMC 3079320. <a target=\"_blank\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3079320\/?tool=pubmed\" rel=\"noopener noreferrer\"><\/a>.<\/p>\n<p>Repunte-Canonigo V, Berton F., <span style=\"text-decoration: underline;\">Cottone P<\/span>, Reifel-Miller A, Roberts AJ, Morales M., Francesconi W, Sanna PP. A potential role for adiponectin receptor 2 (AdipoR2) in the regulation of alcohol intake. <em> Brain Res <\/em> 2010 Jun 21; 1339:11-7. PMC2906226. <a target=\"_blank\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2906226\/?tool=pubmed\" rel=\"noopener noreferrer\"><\/a>.<\/p>\n<p>Roberto M, Cruz MT, Gilpin NW, Sabino V, Schweitzer P, Bajo M, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Madamba SG, Stouffer DF, Zorrilla EP, Koob GF, Siggins GF, Parson LH. Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release play a key role in alcohol dependence. <em> Biol Psychiatry. <\/em>2010 May 1; 67(9):831-9. PMC2883449. <a target=\"_blank\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2883449\/?tool=pubmed\" rel=\"noopener noreferrer\"><\/a>.<\/p>\n<p><span style=\"text-decoration: underline;\">Cottone P<\/span>, Sabino V, Roberto M, Bajo M, Pockros L, Frihauf J, Fekete EM, Steardo L, Rice KC, Grigoriadis D, Conti B, Koob GF, Zorrilla EP. CRF system recruitment mediates dark side of compulsive eating. <em>Proc Natl Acad Sci U S A. <\/em>2009 Nov 24;106(47):20016-20. PMC Journal 2785284<strong><br \/>\n*<\/strong><em>The paper has been evaluated by the Faculty of 1000 Biology: <span style=\"text-decoration: underline;\">9, Excellent<\/span>. Heilig, Markus<\/em> <a target=\"_blank\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2785284\/?tool=pubmed\" rel=\"noopener noreferrer\"><\/a>.<\/p>\n<p>Sabino V, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Zhao Y, Steardo L, Koob GF, Zorrilla EP. Selective reduction of alcohol drinking in Sardinian alcohol-preferring rats by a sigma-1 receptor antagonist. <em>Psychopharmacol<\/em> 2009; 205(2): 327-335. PMC2748837<\/p>\n<p>Fonareva I, Spangler E, Cannella N, Sabino V, <span style=\"text-decoration: underline;\">Cottone P,<\/span> Ciccocioppo R, Zorrilla EP, Ryabinin AE. Increased perioculomotor Urocortin 1 immunoreactivity in genetically selected alcohol preferring rats. <em>Alcohol Clin Exp Res<\/em>. (2009); 33(11):1956-65. PMC 2813693.<a target=\"_blank\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2813693\/?tool=pubmed\" rel=\"noopener noreferrer\"><\/a>.<\/p>\n<p>Greenwell TN, Funk CK, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Richardson HN, Chen SA, Rice KC, Zorrilla EP, Koob GF. Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long-, but not short-access rats. <em>Addiction Biology<\/em> 2009 Apr;14(2):130-43. PMC2748834<\/p>\n<p>Sabino V, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Parylak SL, Steardo L, Zorrilla EP. Sigma-1 receptor knockout mice display a depressive-like phenotype. <em>Behav Brain Res<\/em> 2009; 198(2): 472-476. PMC2667953<\/p>\n<p>Sabino V, <span style=\"text-decoration: underline;\">Cottone P,<\/span> Zhao Y, Iyer M, Steardo L yr, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP. The sigma receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking. <em>Neuropsychopharmacol<\/em> 2009; 34(6): 1482-93. PMC2669694<\/p>\n<p><span style=\"text-decoration: underline;\">Cottone P<\/span>, Sabino V, Steardo L, Zorrilla EP. Consummatory, anxiety-related and metabolic adaptations in female rats with alternating access to preferred food. <em>Psychoneuroendocrinol<\/em> 2009; 34(1):38-49. PMCID: PMC3224792.<\/p>\n<p>Greenwell TN, Walker BM, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Zorrilla EP, Koob GF. The alpha(1) adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration. <em>Pharmacol Biochem Behav<\/em>. 2009; 91(3):295-302. PMC2637926<\/p>\n<p><span style=\"text-decoration: underline;\">Cottone P<\/span>, Sabino V, Steardo S, Zorrilla EP. Intermittent preferred food access reduces the reinforcing efficacy of chow in rats. <em>Am J Physiol Regul Integr Comp Physiol<\/em> 2008; 295(4):R1066-76. PMC2576087<\/p>\n<p><span style=\"text-decoration: underline;\">Cottone P<\/span>, Sabino V, Steardo L, Zorrilla EP. Opioid-dependent anticipatory negative contrast and binge-like eating in rats with limited access to highly preferred food. <em>Neuropsychopharmacol<\/em> 2008; 33(3):524-35. PMC Journal &#8211; In Process<\/p>\n<p>George O, Ghozland S, Azar MR, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Zorrilla EP, Parsons LH, O\u2019Dell LE, Richardson HN, Koob GF. CRF-CRF1 system activation mediates withdrawal-induced anxiety-like behavior and increases in nicotine self-administration in nicotine dependent rats. <em>Proc Natl Acad Sci<\/em> 2007; 104(43):17198-203. PMC2040467<\/p>\n<p><span style=\"text-decoration: underline;\">Cottone P<\/span>, Sabino V, Nagy TR, Rivier JE, Coscina DV, Zorrilla EP. Feeding microstructure in diet-induced obesity susceptible and resistant rats: comparative central effects of urocortin 2. J Physiol 2007; 583(Pt 2):487-504. PMC2277029<\/p>\n<p>Sabino V, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Steardo L, Schmidhammer H, Zorrilla EP. 14-methoxymetopon, a highly potent mu opioid agonist, biphasically affects ethanol intake in Sardinian alcohol-preferring rats. <em>Psychopharmacol<\/em> 2007; 192(4):537-46. PMC Journal &#8211; In Process<\/p>\n<p><span style=\"text-decoration: underline;\">Cottone P<\/span>, Sabino V, Steardo L, Zorrilla EP. FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability. <em>Neuropsychopharmacol<\/em> 2007; 32(5):1069-81. PMC Journal &#8211; In Process<\/p>\n<p>Sabino V, <span style=\"text-decoration: underline;\">Cottone P<\/span>, Koob GF, Steardo L, Lee MJ, Rice KC, Zorrilla EP. Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats. <em>Psychopharmacol<\/em> 2006; 189(2):175-86. PMC Journal &#8211; In Process<\/p>\n<p><a target=\"_blank\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?dispmax=20&amp;db=pubmed&amp;pmfilter_EDatLimit=added%20to%20PubMed%20in%20the%20last%200%20i&amp;cmd_current=Limits&amp;orig_db=PubMed&amp;cmd=Search&amp;term=cottone%2Bp&amp;doptcmdl=DocSum\" title=\"Publication Search via PubMed\" rel=\"noopener noreferrer\">Publication Search via PubMed<\/a><\/p>\n<p><\/div>\n<\/div>\n\n<div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h3 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">Contact<\/h3><div class=\"bu_collapsible_section\" style=\"display: none;\"><\/p>\n<p>Office: R-618<br \/>\nOffice Phone: 617-358-1950<br \/>\nLab Phone: 617-358-1949<br \/>\n<\/div>\n<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>Associate Professor of Pharmacology and Psychiatry Department of Pharmacology Ph.D.: University of Rome La Sapienza, Rome, Italy (click for lab site) Research Interests Dr. Cottone is co-director of the Laboratory of Addictive Disorders. Dr. Cottone\u2019s research interests focus on the neurobiological substrates of motivated behaviors including feeding and addiction. The major goal of Dr. Cottone\u2019s [&hellip;]<\/p>\n","protected":false},"author":947,"featured_media":0,"parent":1786,"menu_order":20,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages\/1421"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/users\/947"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/comments?post=1421"}],"version-history":[{"count":51,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages\/1421\/revisions"}],"predecessor-version":[{"id":23992,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages\/1421\/revisions\/23992"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/pages\/1786"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/ppb\/wp-json\/wp\/v2\/media?parent=1421"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}