Pathogen Induced Inflammation

  A major focus of the pathogen induced inflammation group is to understand the mechanisms by which microbial pathogens induce inflammation via the innate immune response. The innate immune system is the first line of defense against invading pathogens, and is required to optimize the more specialized adaptive immune response.  Several bacterial, viral, and parasitic pathogens are under investigation including several emerging and re emerging infectious pathogens. Much of this work involves detailed mechanistic studies examining pathogen interactions with a variety of host immune cells including macrophages, platelets, dendritic cells, B and T cells, epithelial and endothelial cells.  Likewise this group of investigators utilizes mouse specific models of inflammation employing both genetic knockout mice and transgenic mouse models.