![\"Lindsay](\"\/ophthalmology\/files\/2012\/07\/lfarrer_000.jpg\" "\\"Lindsay")
<\/p>\n<\/p>\n
Professor of Medicine, Neurology, Ophthalmology,
\nGenetics & Genomics, Epidemiology, &
\nBiostatistics
\nChief, Genetics Program<\/p>\n
Phone: 617.638.5393
\nFax:617.638.4275<\/p>\n
Email: farrer@bu.edu<\/a><\/p>\n Website: http:\/\/genetics.bumc.bu.edu<\/a><\/p>\n Dr. Lindsay Farrer is a medical geneticist at Boston University Dr. Farrer\u2019s research has lead to more than 300 publications on Under Dr. Farrer\u2019s leadership, the MIRAGE Project, a multi-center Lindsay Farrer, PhD is a senior investigator within the ADC. He is Dr. Farrer was named an Alfred P. Sloan Research Fellow, recognized Naj AC, Jun G, Beecham GW,\u2026[148 co-authors]\u2026Pericak-Vance MA, Farrer Logue MW, Schu M, Vardarajan BN, Buros J, Green RC, Go R, Griffith P, Farrell JJ, Sherva RM, Luo H-Y, Chen Z-Y, Ha SY, Li CK, Lee ACW, Li Erlich PM, Lunetta KL, Cupples, LA, Abraham CR, Green RC, Baldwin CT, Reitz C, Tokuhiro S, Clark LN, Conrad C, Vonsattel J-P, Palotas A, Solovieff N, Milton JN, Hartley SW, Sherva R, Sebastiani P, Dworkis Farrer LA, Kranzler HR, Yu Y, Weiss RD, Brady, KT, Cubells JF, Green RC, Roberts JS, Cupples LA, Relkin NR, Whitehouse PJ, Brown T, Rogaeva E, Meng Y, Lee JH, Gu Y-J, Zou F, Kawarai T, Katayama T, Edwards AO, Ritter R, Abel KJ, Manning A, Panhuysen C, Farrer LA. Saleh M, Vaillancourt JP, Graham RK, Huyck M, Srinivasula SM, Alnemri Farrer LA , Bowirrat A, Friedland RP, Waraska K, Korczyn AD, Baldwin Kennedy JL, Farrer LA, Andreasen NC, Mayeux R, St. George-Hyslop P. Green RC, Cupples LA, Go R, Benke KS, Edeki T, Griffith PA, Williams Graff-Radford N, Green RC, Go RC, Hutton ML, Edeki T, Bachman D, Riazanskaya N, Lukiw WJ, Grigorenko A, Korovaitseva G, , Molyaka Y, Professor of Medicine, Neurology, Ophthalmology, Genetics & Genomics, Epidemiology, & Biostatistics Chief, Genetics Program Phone: 617.638.5393 Fax:617.638.4275 Email: farrer@bu.edu Website: http:\/\/genetics.bumc.bu.edu Background Dr. Lindsay Farrer is a medical geneticist at Boston University Schools of Medicine and Public Health where he is Chief of Biomedical Genetics and a Professor of Medicine, Neurology, Ophthalmology, Genetics […]<\/p>\n","protected":false},"author":3705,"featured_media":0,"parent":547,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/ophthalmology\/wp-json\/wp\/v2\/pages\/916"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/ophthalmology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/ophthalmology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ophthalmology\/wp-json\/wp\/v2\/users\/3705"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ophthalmology\/wp-json\/wp\/v2\/comments?post=916"}],"version-history":[{"count":20,"href":"https:\/\/www.bumc.bu.edu\/ophthalmology\/wp-json\/wp\/v2\/pages\/916\/revisions"}],"predecessor-version":[{"id":1002,"href":"https:\/\/www.bumc.bu.edu\/ophthalmology\/wp-json\/wp\/v2\/pages\/916\/revisions\/1002"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ophthalmology\/wp-json\/wp\/v2\/pages\/547"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/ophthalmology\/wp-json\/wp\/v2\/media?parent=916"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n <\/p>\nBackground<\/h2>\n
\nSchools of Medicine and Public Health where he is Chief of Biomedical
\nGenetics and a Professor of Medicine, Neurology, Ophthalmology, Genetics
\n& Genomics, Epidemiology, and Biostatistics. Dr. Farrer is a
\ngraduate of the University of North Carolina in Chapel Hill, received
\nhis Ph.D. from the Indiana University School of Medicine, and gained
\nadditional training in genetic epidemiology at Yale University. He holds
\nadjunct faculty positions at Harvard Medical School, Massachusetts
\nGeneral Hospital, and the Veterans Administration Medical Center in
\nBedford, Massachusetts. He is a Founding Fellow of the American College
\nof Medical Genetics. Dr. Farrer teaches several courses in human
\ngenetics and genetic epidemiology at Boston University, directs Boston
\nUniversity\u2019s Molecular Genetics Core Facility which offers DNA
\ngenotyping and sequencing services to investigators at the Boston
\nMedical Center, and provides genetic counseling and testing to patients
\nwith a variety of inherited conditions.<\/p>\nResearch Interests<\/h2>\n
\ngenetic risk factors for several familial neurodegenerative and other
\nchronic diseases. In collaboration with other laboratories worldwide,
\nhis group has localized genes causing a variety of rare and common
\ndisorders including Alzheimer disease (AD), Wilson disease,
\nMachado-Joseph disease, Waardenburg syndrome, hypertension,
\nsensorineural deafness, and osteoarthritis. His group identified a
\nfunctional genetic variant in the complement factor H gene which
\naccounts for more than 30% of the attributable risk for age-related
\nmacular degeneration (AMD), the leading cause of progressive vision loss
\nand blindness in the elderly. In collaboration with other researchers,
\nDr. Farrer is conducting genome wide association studies (GWAS) for
\nseveral disorders including AD, substance dependence (cocaine, opiates,
\nnicotine and alcohol), AMD and vasculitis.\u00a0 Dr. Farrer\u2019s team is
\nalso developing methods for locating genes that influence the natural
\nhistory of complex diseases and pharmacogenetic response.<\/p>\n
\nstudy of AD funded since 1991 by the National Institute on Aging, has
\nmade several important contributions to our understanding of the
\ninteractions between genetic and environmental factors for the disorder.
\nThis study has a particular emphasis on the genetics of AD in African
\nAmericans. Thus far, detailed family histories, risk factor data, and
\nDNA specimens from more than 2,500 AD families have been collected as a
\npart of this program. MIRAGE was the first study to demonstrate that
\ngenetic factors have a major role in the development of AD and that APOE
\n\u03b54 is more weakly associated with disease in men and persons older than
\n75 years.\u00a0 Dr. Farrer co-directed the international effort which
\ndemonstrated that SORL1 is genetically and functionally associated with
\nAD, thus implicating intracellular protein trafficking as integral
\npathway in AD.\u00a0 His laboratory conducted genome wide association
\nstudies (GWAS) for AD in several populations including African Americans
\nand an inbred Israeli-Arab community.\u00a0 Dr. Farrer serves on the
\nExecutive Committee of the national Alzheimer Disease Genetics Consortium<\/a>
\nand co-directs the data analysis effort for this large NIH-funded
\nproject.\u00a0 He and his colleagues recently discovered four new
\nAlzheimer genes in the largest GWAS of AD to date.<\/p>\nADC role<\/h2>\n
\nProject Director for the Multi-Institutional Research in Alzheimer\u2019s
\nGenetic Epidemiology (MIRAGE) study.<\/p>\nAwards\/Memberships<\/h2>\n
\nby \u201cWho\u2019s Who in the World\u201d, and received several awards including the
\nDistinguished Alumnus Award from the Department of Medical and Molecular
\nGenetics at Indiana University School of Medicine and an award for
\nOutstanding Scientific Achievement from the Department of Medicine at
\nBoston University. He is a member of several scientific and medical
\norganizations including the American Society of Human Genetics<\/a>. He is a founding member of International Genetic Epidemiology Society<\/a> and was elected to the World Federation of Neurology and Human Genome Organization.<\/p>\nRecent Publications<\/h2>\n
\nLA, Schellenberg GD. Genome-wide association study of late-onset
\nAlzheimer disease identifies disease associated variants in
\nMS4A4\/MS4A6E, CD2AP, CD33, and EPHA1.\u00a0 Nat Genet 2011. (In press)<\/p>\n
\nAkomolafe A, Obisesan TO, Shatz R, Borenstein A, Cupples LA, Lunetta
\nKL, Fallin MD, Baldwin CT, Farrer LA, for the MIRAGE Study Group.
\nGenetic variants at multiple loci influence Alzheimer disease risk
\nin African Americans. Arch Neurol 2011. (In press)<\/p>\n
\nCK, Yuen HL, So JCC, Ma ESK, Chan LC, Chan V, Sebastiani P, Farrer LA,
\nBaldwin CT, Steinberg MH, Chui DHK.\u00a0 A 3-bp deletion in the
\nHBS1L-MYB intergenic region on chromosome 6q23 is associated with Hb F
\nexpression.\u00a0 Blood 2011 Mar 8 (Epub ahead of print).<\/p>\n
\nFarrer LA.\u00a0 Serum paraoxonase activity is associated with variants
\nin the PON gene cluster and risk of Alzheimer disease.\u00a0 Neurobiol
\nAging 2010 Oct 25 (Epub ahead of print). PMID: 20980077.<\/p>\n
\nLantigua R, Medrano M, Jim\u00e9nez-Vel\u00e1zquez IZ, Haines JL,Pericak-Vance MA,
\nFarrer LA, Lee JH, Rogaeva E, St. George-Hyslop P, Mayeux
\nR.\u00a0SORCS1 alters amyloid precursor protein processing and variants
\nmay increase Alzheimer\u2019s disease risk. Ann Neurol 2011; 69:47-64.<\/p>\n
\nDA, Klings E, Farrer LA, Garrett ME, Ashley-Koch A, Telen MJ, Fucharoen
\nS, Ha SY, Li CK, Chui DHK, Baldwin CT, Steinberg MH.\u00a0 Fetal
\nhemoglobin in sickle cell anemia: genome-wide association studies
\nsuggest a regulatory region in the 5\u2032 olfactory receptor gene
\ncluster.\u00a0 Blood 2010 Mar 4;115(9):1815-22. Epub 2009 Dec 16.<\/p>\n
\nGelernter J.\u00a0 Association of Variants in the \u03b1-endomannosidase
\n(MANEA) gene with cocaine-related behaviors.\u00a0 Arch Gen Psychiatry
\n2009; 66:267-274.<\/p>\n
\nLaRusse Eckert S, Butson M, Sadovnick AD, Quaid KA, Chen C, Cook-Deegan
\nR, Farrer LA for the REVEAL Study Group.\u00a0 A randomized trial of
\nAPOE disclosure for risk of Alzheimer\u2019s disease: The REVEAL Study.
\nNew Engl J Med 2009; 361:245-254.<\/p>\n
\nBaldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL,
\nPardossi-Piquard R, Bohm C, Wakutani Y, Cupples LA, T.Cuenco K, Green
\nRC, Pinessi L, Rainero I, Sorbi S, Bruni A, Duara R, Friedland R,
\nInzelberg R, Hampe W, Bujo H, Song Y, Andersen O, Graff-Radford N,
\nPetersen R, Dickson D, Der SD, Fraser PE, Schmitt-Ulms G, Younkin S,
\nMayeux R, Farrer LA, St George-Hyslop P.\u00a0 The sortilin-related
\nreceptor SORL1 is functionally and genetically associated with
\nAlzheimer\u2019s disease.\u00a0 Nat Genet 2007; 39:168-177.<\/p>\n
\nComplement factor H polymorphism and age-related macular degeneration. Science<\/em> 2005; 308: 421-424.<\/p>\n
\nES, Steinberg MH, Nolan V, Baldwin, CT, Hotchkiss RS, Buchman TG,
\nZehnbauer BA, Hayden MR, Farrer LA, Roy S, Nicholson DW. Differential
\nmodulation of endotoxin responsiveness by human caspase-12 polymorphs. Nature<\/em> 2004; 429: 75-79.<\/p>\n
\nCT. Identification of multiple loci for Alzheimer disease in a
\nconsanguineous Israeli-Arab Community. Hum Mol Genet<\/em> 2003;12: 415-422.<\/p>\n
\nThe genetics of adult-onset neuropsychiatric disease: complexities and
\nconundra? Science<\/em> 2003; 302: 822-826<\/p>\n
\nM, Hipps Y, Graff-Radford N, Bachman D, Farrer LA. Risk of dementia
\namong White and African American relatives of patients with Alzheimer
\ndisease. JAMA <\/em>2002; 287: 329-336.<\/p>\n
\nAdamson JL, Griffith P, Willis FB, Williams M, Hipps Y, Haines JL,
\nCupples LA, Farrer LA. Association between apolipoprotein E genotype and
\nAlzheimer disease in African American subjects. Arch Neurol<\/em> 2002; 59:594-600.<\/p>\n
\nNicolaou M, Farrer L, Bazan NG, Rogaev EI. Regulatory region variability
\nin the human presenilin-2 (PSEN2) gene: modulation of gene activity and
\npotential contribution to the risk for AD. Mol Psychiatry<\/em> 2002; 7:891-898.<\/p>\n","protected":false},"excerpt":{"rendered":"