{"id":845,"date":"2012-07-19T12:42:51","date_gmt":"2012-07-19T16:42:51","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/ophthalmology\/?page_id=845"},"modified":"2012-07-19T16:01:55","modified_gmt":"2012-07-19T20:01:55","slug":"joyce_wong_phd","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/ophthalmology\/core\/joyce_wong_phd\/","title":{"rendered":"Joyce Y. Wong, PhD"},"content":{"rendered":"

\"Wong-Profile\"<\/p>\n

Associate Professor, Biomedical Engineering
\nBiomimetic Materials Engineering Laboratory<\/a>
\nCellular and Subcellular Mechanics Laboratory<\/a>
\nCenter for Nanoscience and Nanobiotechnology<\/a>
\nPh.D.,Materials Science and Engineering, Program in Polymer Science and Technology, Massachusetts Institute of Technology
\nS.B., Materials Science and Engineering, Massachusetts Institute of Technology
\nPhone: (617) 353-2374; Fax: (617) 353-6766
\nEmail: jywong@bu.edu<\/a>
\nOffice: ERB 520A<\/a><\/p>\n

Office hours: By appointment<\/p>\n

Research Interests<\/h2>\n

Biomaterials, tailoring cell-material interfaces for drug delivery
\nand tissue engineering applications; direct, quantitative measurement of
\nbiological interactions.<\/p>\n

Current Research<\/h2>\n

The Biomimetic Materials Engineering Laboratory is focused on the
\ndevelopment of biomaterials to probe how structure, material properties
\nand composition of the cell-biomaterial interface affect fundamental
\ncellular processes. Specifically, we are interested in developing
\nsubstrata with features that mimic physiological and pathophysiological
\nenvironments to study fundamental cellular processes at the
\nbiointerface. Current research projects include tissue engineering of
\nsmall diameter blood vessels for bypass and intravascular pharmacology (e.g.<\/em><\/em>
\nstents); development of targeted nano- and micro-particle contrast
\nagents for multi-modal (magnetic resonance, ultrasound, and optical)
\ndetection of atherosclerotic and vulnerable plaque; and engineering
\nbiomimetic systems to study restenosis and breast cancer.<\/p>\n

Selected Recent Publications<\/h2>\n

Duncanson, W.J, K. Oum, J.R. Eisenbrey, R.O. Cleveland, M. A. Wheatley, J.Y. Wong <\/strong>\u201cTargeted binding of PEG-lipid\u00a0\u00a0\u00a0 modified polymer ultrasound contrast agents with tiered surface architecture\u201d Biotechnology and Bioengineering.<\/em> (accepted)<\/p>\n

Isenberg, B.C.*, P.A. DiMilla*, M. Walker, S. Kim, and J. Y. Wong<\/strong> (*co-first authors) \u201cVascular smooth muscle cell durotaxis depends on substrate stiffness gradient strength\u201d Biophys. J.<\/em> 97: 1313.\u00a0 (2009)<\/p>\n

Amstad, E., S. Zurcher, A. Mashaghi, J.Y. Wong<\/strong>, M. Textor, and E. Reimhult \u201cSurface Functionalization of Single Superparamagnetic Iron Oxide Nanoparticles for Targeted Magnetic Resonance Imaging<\/a>\u201d Small.<\/em> 5 (11): 1334-1342. (2009)<\/p>\n

Williams, C., Y. Tsuda, B.C. Isenberg, M. Yamato, T. Shimizu, T. Okano, and J.Y. Wong<\/strong> \u201cAligned cell sheets grown on thermo-responsive substrates with micro-contact printed protein patterns\u201d Advanced Materials. <\/em>21 (21): 2161-2164. (2009)<\/p>\n

Williams, C.*, J. Liao*, E.M. Joyce, J.B. Leach, M.S. Sacks, and J.Y. Wong<\/strong>
\n(*co-first authors) \u201cChanges in structural and mechanical properties in
\ndecellularized arteries: Implications for vascular tissue engineering\u201d Acta Biomaterialia. <\/em>5 (4): 993-1005.\u00a0 (2008)<\/p>\n

Jacot, J.G. and J.Y. Wong<\/strong> \u201cEndothelial injury
\ninduces vascular smooth muscle cell proliferation in highly localized
\nregions of a direct contact co-culture system\u201d Cell Biochemistry and Biophysics.<\/em> 52 (1): 37-46. (2008)<\/p>\n

Isenberg, B.C., Tsuda, Y., Williams, C., Shimizu, T., Yamato, M., Okano, T. and Wong, J.Y. <\/strong>\u201cA Thermoresponsive, Microtextured Substrate for Cell Sheet Engineering with Defined Structural Organization\u201d Biomaterials.<\/em> 29 (17): 2565-72. (2008)<\/p>\n

Duncanson, W.J., Figa, M.A., Hallock, K., Zalipsky, S., Hamilton, J.A. and Wong, J.Y.<\/strong> \u201cTargeted Binding of PLA Microparticles with Lipid-PEG-tethered Ligands\u201d Biomaterials.<\/em> 28: 4991-4999. (2007)<\/p>\n

Koester, S., Leach, J.B., Pfohl, T., and Wong, J.Y.<\/strong> \u201cVisualization of Flow-Aligned Type I Collagen Self-Assembly in Tunable pH-Gradients\u201d Langmuir.<\/em> 23: 357-359. (2007)<\/p>\n

Gaudet, C., Marganski, W.A., Kim, S., Brown, C.T., Gunderia, V., Dembo, M.<\/a> and Wong, J.Y.<\/strong> \u201cInfluence of Substratum Type I Collagen Concentration on Fibroblast Spreading, Motility and Contractility\u201d Biophys. J.<\/em> 85 (5): 3329-3335. (2003)<\/p>\n","protected":false},"excerpt":{"rendered":"

Associate Professor, Biomedical Engineering Biomimetic Materials Engineering Laboratory Cellular and Subcellular Mechanics Laboratory Center for Nanoscience and Nanobiotechnology Ph.D.,Materials Science and Engineering, Program in Polymer Science and Technology, Massachusetts Institute of Technology S.B., Materials Science and Engineering, Massachusetts Institute of Technology Phone: (617) 353-2374; Fax: (617) 353-6766 Email: jywong@bu.edu Office: ERB 520A Office hours: By […]<\/p>\n","protected":false},"author":3705,"featured_media":0,"parent":547,"menu_order":9,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/ophthalmology\/wp-json\/wp\/v2\/pages\/845"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/ophthalmology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/ophthalmology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ophthalmology\/wp-json\/wp\/v2\/users\/3705"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ophthalmology\/wp-json\/wp\/v2\/comments?post=845"}],"version-history":[{"count":13,"href":"https:\/\/www.bumc.bu.edu\/ophthalmology\/wp-json\/wp\/v2\/pages\/845\/revisions"}],"predecessor-version":[{"id":848,"href":"https:\/\/www.bumc.bu.edu\/ophthalmology\/wp-json\/wp\/v2\/pages\/845\/revisions\/848"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ophthalmology\/wp-json\/wp\/v2\/pages\/547"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/ophthalmology\/wp-json\/wp\/v2\/media?parent=845"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}