{"id":7615,"date":"2021-11-03T10:44:19","date_gmt":"2021-11-03T14:44:19","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/neurology\/?page_id=7615"},"modified":"2021-11-03T12:20:29","modified_gmt":"2021-11-03T16:20:29","slug":"neurocritical-care","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/neurology\/research-2\/neurocritical-care\/","title":{"rendered":"Neurocritical Care"},"content":{"rendered":"<p><span style=\"color: #000000;\"><img loading=\"lazy\" src=\"\/neurology\/files\/2021\/11\/BDA97FF5-6133-4888-B20E-ED660D2BFE8C_1_201_a-scaled.jpeg\" alt=\"\" width=\"344\" height=\"199\" class=\"wp-image-7619 alignright\" srcset=\"https:\/\/www.bumc.bu.edu\/neurology\/files\/2021\/11\/BDA97FF5-6133-4888-B20E-ED660D2BFE8C_1_201_a-scaled.jpeg 2560w, https:\/\/www.bumc.bu.edu\/neurology\/files\/2021\/11\/BDA97FF5-6133-4888-B20E-ED660D2BFE8C_1_201_a-519x300.jpeg 519w, https:\/\/www.bumc.bu.edu\/neurology\/files\/2021\/11\/BDA97FF5-6133-4888-B20E-ED660D2BFE8C_1_201_a-1024x592.jpeg 1024w, https:\/\/www.bumc.bu.edu\/neurology\/files\/2021\/11\/BDA97FF5-6133-4888-B20E-ED660D2BFE8C_1_201_a-768x444.jpeg 768w, https:\/\/www.bumc.bu.edu\/neurology\/files\/2021\/11\/BDA97FF5-6133-4888-B20E-ED660D2BFE8C_1_201_a-1536x888.jpeg 1536w, https:\/\/www.bumc.bu.edu\/neurology\/files\/2021\/11\/BDA97FF5-6133-4888-B20E-ED660D2BFE8C_1_201_a-2048x1184.jpeg 2048w\" sizes=\"(max-width: 344px) 100vw, 344px\" \/>The Division of Neurocritical Care provides care for critically ill patients with a wide variety of neurologic emergencies.\u00a0 Our research parallels illnesses most frequently affecting our patient population with a focus on brain death, coma post-cardiac arrest, traumatic brain injury, neurologic infections including COVID-19 and infectious endocarditis, and development of tools for early identification of patients with secondary decline.\u00a0 In addition we participate in acute stroke and epilepsy clinical trials.\u00a0<\/span><\/p>\n<h5><span style=\"color: #008080;\">Current Research<\/span><\/h5>\n<p><span style=\"color: #000000;\"><strong>Neurologic Infections<\/strong> (PI: Anna Cervantes)<\/span><\/p>\n<ul>\n<li><span style=\"text-decoration: underline;\"><span style=\"color: #000000; text-decoration: underline;\">COVID 19<\/span><\/span><br \/>\n<span style=\"color: #000000;\">Characterizing acute neurologic complications of hospitalized patients with COVID-19<\/span><br \/>\n<span style=\"color: #000000;\">Observational study of recovery post-COVID (Post-Acute Sequelae of COVID-19) as part of a Boston consortium<\/span><\/li>\n<li><span style=\"color: #000000;\"><span style=\"text-decoration: underline;\">Infectious Endocarditis<\/span> (collaboration with CT surgery, cardiology, infectious disease, and addiction medicine)<\/span><br \/>\n<span style=\"color: #000000;\">Characterizing neurologic complications in tricuspid valve disease<\/span><br \/>\n<span style=\"color: #000000;\">Investigating acute stroke treatment options for IE related stroke<\/span><br \/>\n<span style=\"color: #000000;\">Seizures during IE and epilepsy in IE survivors<\/span><\/li>\n<li><span style=\"color: #000000;\"><span style=\"text-decoration: underline;\">Infection in Hospitalized patients with acute severe traumatic brain injury<\/span> (collaboration with NCC, Neurosurgery, and Trauma Surgery\/Surgical Critical Care) (PI: Ali Daneshmand)<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000;\"><strong>Medical Ethics in the ICU<\/strong> (PI: Anna Cervantes)<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000;\">Evaluation of Crisis Standards of Care triage protocols for determining allocation of limited resources<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000;\"><strong>Outcomes following Cardiac Arrest<\/strong> (PI: David Greer)<\/span><\/p>\n<ul><\/ul>\n<ul>\n<li><span style=\"color: #000000;\">MOCA &#8211; advanced MRI and EEG techniques to help determine recovery of arousal post-cardiac arrest<\/span><\/li>\n<\/ul>\n<ul>\n<li><span style=\"color: #000000;\">MOCHA\/SPARE &#8211; cooperative study with Brazil looking at the impact of withdrawal of life-sustaining therapy on outcomes and prognostic tool performance<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000;\"><strong>Brain Death<\/strong> (PI: David Greer)<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000;\">New England Brain Death Database &#8211; a national database for collecting brain death cases prospectively and retrospectively to answer the many remaining questions in brain death<\/span><\/li>\n<\/ul>\n<ol>\n<li style=\"list-style-type: none;\">\n<ol>\n<li style=\"list-style-type: none;\">\n<ol>\n<li style=\"list-style-type: none;\">\n<ol>\n<li style=\"list-style-type: none;\">\n<ol start=\"7\"><\/ol>\n<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<p><span style=\"color: #000000;\"><strong>Dynamic Risk Prediction of Life threatening Mass Effect<\/strong> (PI: Charlene Ong)<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000;\">Retrospective dynamic models of life threatening mass effect after ischemic stroke<\/span><\/li>\n<li>Prospective dynamic models using Quantitative Pupillometry<\/li>\n<\/ul>\n<p><span style=\"color: #000000;\"><strong>LTME Risk Prediction Automated Email<\/strong> (PI: Charlene Ong)<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000;\">Obtain survey feedback on automated emails calculating risk of EDEMA to clinical providers (IRB approved, not started yet)<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000;\"><strong>Oculography<\/strong> (PI: Charlene Ong)<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000;\">Automated eye movement detection algorithm using sleep study EOG<\/span><\/li>\n<li><span style=\"color: #000000;\">Enrollment of comatose cardiac arrest patients to determine qualitative eye movements and recovery potential<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000;\"><strong>Pupillometry<\/strong> (PI: Charlene Ong)<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000;\">Midbrain Compression and Pupillometry: Test the association of quantitative pupil markers and quantitative midbrain compression in large stroke and intraparenchymal hemorrhage<\/span><\/li>\n<li><span style=\"color: #000000;\">Examination of associations between analgosedatives and quantitative pupillometry<\/span><\/li>\n<li><span style=\"color: #000000;\">Case series of pre and post quantitative pupil metrics and hemicraniectomy<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000;\"><strong>Subarachnoid Hemorrhage<\/strong> (PI: David Chung)<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000;\">Reducing complications and optimizing outcomes in hospitalized patients following brain aneurysm rupture<\/span><\/li>\n<li><span style=\"color: #000000;\">The role of cortical spreading depolarizations in injury progression in subarachnoid hemorrhage and trauma<\/span><\/li>\n<li><span style=\"color: #000000;\">Functional connectivity and long term cognitive deficits following subarachnoid hemorrhage and trauma<\/span><\/li>\n<li><span style=\"color: #000000;\">Non-invasive cerebral blood flow determination in acutely brain injured patients<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000;\"><strong>Perihematomal edema (PHE) in the setting of spontaneous intracranial hemorrhage (ICH)<\/strong> (PI: Courtney Takahashi)<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000;\">Developing and refining a semi-automated computer program to accurately measure PHE volumes\u00a0<\/span><\/li>\n<li><span style=\"color: #000000;\">Determining if PHE volumes correlate with outcomes (e.g. mRS)\u00a0<\/span><\/li>\n<li><span style=\"color: #000000;\">Determining the natural history of PHE development and abatement over time\u00a0<\/span><\/li>\n<li><span style=\"color: #000000;\">Overall goal is to evaluate the utility of PHE as a biomarker and possible intervention point to improve outcomes in ICH\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000;\"><strong>Neurocritical Care Nursing education<\/strong>\u00a0(PI: Courtney Takahashi)<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000;\">Developing modern learning techniques (e.g. small group evaluation) and applying them to see if they can help with improved retention and synthesis. Topics include neuroanatomy, case based scenarios, and imaging.\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000;\"><strong>Traumatic Brain Injury<\/strong> (collaboration with NCC, Neurosurgery, and Trauma Surgery\/Surgical Critical Care) (PI: Ali Daneshmand)<\/span><\/p>\n<ul>\n<li>Impact of infections on outcomes in TBI<\/li>\n<li>Prognostication models in TBI<\/li>\n<\/ul>\n<p><strong><span style=\"color: #000000;\">Status Epilepticus<\/span><\/strong><\/p>\n<ul>\n<li><span style=\"color: #000000;\">RAISE &#8211; a randomized, double-blind, placebo-controlled trial that will evaluate the efficacy and safety of IV ganaxolone in RSE<\/span><\/li>\n<\/ul>\n<h5><span style=\"color: #008080;\">Research Faculty:<\/span><\/h5>\n<p><a href=\"https:\/\/www.bumc.bu.edu\/neurology\/profile\/anna-m-cervantes-arslanian-md\/\"><span style=\"color: #000000;\">Anna Cervantes-Arslanian, MD<\/span><\/a><br \/>\n<a href=\"https:\/\/www.bumc.bu.edu\/neurology\/profile\/david-m-greer-m-d-m-a\/\"><span style=\"color: #000000;\">David Greer, MD, MA<\/span><\/a><br \/>\n<a href=\"https:\/\/www.bumc.bu.edu\/neurology\/profile\/courtney-takahashi-md-mcr\/\"><span style=\"color: #000000;\">Courtney Takahashi, MD, MCR<\/span><\/a><br \/>\n<a href=\"https:\/\/www.bumc.bu.edu\/neurology\/profile\/charlene-j-ong-md\/\"><span style=\"color: #000000;\">Charlene Ong, MD, MPHS<\/span><\/a><br \/>\n<a href=\"https:\/\/www.bumc.bu.edu\/neurology\/profile\/david-y-chung-m-d-ph-d\/\"><span style=\"color: #000000;\">David Chung, MD, PhD<\/span><\/a><br \/>\n<a href=\"https:\/\/www.bumc.bu.edu\/neurology\/profile\/ali-daneshmand-md-mph\/\"><span style=\"color: #000000;\">Ali Daneshmand, MD, MPH<\/span><\/a><br \/>\n<a href=\"https:\/\/www.bumc.bu.edu\/neurology\/profile\/kushak-suchdev-md\/\"><span style=\"color: #000000;\">Kushak Suchdev, MD\u00a0<\/span><\/a><\/p>\n<h5><span style=\"color: #008080;\">Grants:<\/span><\/h5>\n<p><span style=\"color: #000000;\">David Chung (<a href=\"https:\/\/www.massgeneral.org\/neurology\/research\/david-chung-lab\">Chung Lab<\/a>):<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000;\">Non-Invasive Blood Flow to Predict Recovery from Coma in Brain Injured Patients (CTSI Pilot award 2021)<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000;\">Charlene Ong:<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000;\">Peter Paul Career Development Award \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/span><\/li>\n<li><span style=\"color: #000000;\">Grinspoon Family Junior Faculty Research Award<\/span><\/li>\n<li><span style=\"color: #000000;\">K23NS116033, Dynamic Risk Prediction of Life Threatening Mass Effect after Ischemic Stroke<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #000000;\">David Greer:<\/span><\/p>\n<ul>\n<li><span style=\"color: #000000;\">R01NS102574 &#8211; Multimodal network connectivity architecture (MOCA) of the brain and its role in the recovery of consciousness in comatose cardiac arrest patients<\/span><\/li>\n<\/ul>\n<h5><span style=\"color: #008080;\">Selected Publications:<\/span><\/h5>\n<ul>\n<li><span style=\"color: #000000;\">Takahashi, CE; Brambrink AM, Aziz MF, Macri E, Raines J, Multani-Kohol A, Hinson HE, Lutsep HL, Clark WM, Fields, J. Association of intraprocedural blood pressure and end tidal carbon dioxide with outcome after acute stroke intervention.\u00a0 <em>Neurocritical Care<\/em>, 2014: 202-208<em>.\u00a0 <\/em>PMID 24114519<\/span><\/li>\n<li><span style=\"color: #000000;\">Sweeney EM, Thakur KT, Lyons JL, Smith BR, Willey JZ, Cervantes-Arslanian AM<strong>,<\/strong> Hickey MK, Uchino K, Haussen DC, Koch S, Schwamm LH, Elkind MS, Shinohara RT, Mateen FJ. Outcomes of intravenous tissue plasminogen activator for acute ischaemic stroke in HIV-infected adults. <em>Eur J Neurol<\/em>. 2014 Jul 10. PMID: 25040336<\/span><\/li>\n<li><span style=\"color: #000000;\">Ong CJ, Dhand A, Diringer MN. Early withdrawal decision making in patients with coma after cardiac arrest: a qualitative study of intensive care clinicians. Neurocritical Care 2016;25(2):258-65. PMID 27112149<\/span><\/li>\n<li><span style=\"color: #000000;\">Burns JD, Rindler RS, Carr C, Lau H, Cervantes-Arslanian AM, Green-LaRoche DM, Salem R, Kase CS. Delay in Diagnosis of Basilar Artery Stroke. Neurocrit Care. 2016 Apr; 24(2):172-9. PMID:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26503513\" style=\"color: #000000;\">26503513<\/a><\/span><\/li>\n<li><span style=\"color: #000000;\">Chung DY, Oka F, Ayata C. Spreading Depolarizations: A Therapeutic Target Against Delayed Cerebral Ischemia After Subarachnoid Hemorrhage. J Clin Neurophysiol. 2016 Jun; 33(3):196-202. PMID: 27258442.<\/span><\/li>\n<li><span style=\"color: #000000;\">Chung DY, Claassen J, Agarwal S, Schmidt JM, Mayer SA. Assessment of Noninvasive Regional Brain Oximetry in Posterior Reversible Encephalopathy Syndrome and Reversible Cerebral Vasoconstriction Syndrome. J Intensive Care Med. 2016 Jul; 31(6):415-9. PMID: 26732768.<\/span><\/li>\n<li><span style=\"color: #000000;\">Mukerji SS, Misra V, Lorenz D, Cervantes-Arslanian AM, Lyons J, Chalkias S, Wurcel A, Burke D, Venna N, Morgello S, Koralnik IJ and Gabuzda D. Temporal Patterns and Drug Resistance in CSF Viral Escape Among ART-Experienced HIV-1 Infected Adults. <em>J Acquir Immune Defic Syndr<\/em>. 2017;75:246-255. PMID: 28328546<\/span><\/li>\n<li><span style=\"color: #000000;\">Ong CJ, Gluckstein JA, Laurido-Soto O, Yan Y, Dhar R, Lee JM. Enhanced detection of edema in malignant anterior circulation stroke (EDEMA) score: A risk prediction tool. Stroke 2017;48(7):1969-72. PMID: 2847333<\/span><\/li>\n<li><span style=\"color: #000000;\">AbdelRazek MA, Gutierrez J, Mampre D,\u00a0Cervantes-Arslanian\u00a0A, Ormseth C, Haussen D, Thakur KT, Lyons JL, Smith BR, O&#8217;Connor O, Willey JZ, Mateen FJ. Intravenous Thrombolysis for Stroke and Presumed Stroke in Human Immunodeficiency Virus-Infected Adults: A Retrospective, Multicenter US Study. <em>Stroke<\/em> 2018 Jan;49(1):228-231. PMID:29273597<\/span><\/li>\n<li><span style=\"color: #000000;\">Chung DY, Sugimoto K, Fischer P, B\u00f6hm M, Takizawa T, Sadeghian H, Morais A, Harriott A, Oka F, Qin T, Henninger N, Yaseen MA, Sakad\u017eic S, Ayata C. Real-time non-invasive in vivo visible light detection of cortical spreading depolarizations in mice. J Neurosci Methods. 2018 11 01; 309:143-146. PMID: 30194041.<\/span><\/li>\n<li><span style=\"color: #000000;\">Chung DY, Olson DM, John S, Mohamed W, Kumar MA, Thompson BB, Rordorf GA. Evidence-Based Management of External Ventricular Drains. Curr Neurol Neurosci Rep. 2019 11 26; 19(12):94. PMID: 31773310.<\/span><\/li>\n<li><span style=\"color: #000000;\">Chung DY, Sadeghian H, Qin T, Lule S, Lee H, Karakaya F, Goins S, Oka F, Yaseen MA, Houben T, Tolner EA, van den Maagdenberg AMJM, Whalen MJ, Sakad\u017eic S, Ayata C. Determinants of Optogenetic Cortical Spreading Depolarizations. Cereb Cortex. 2019 03 01; 29(3):1150-1161. PMID: 29425263.<\/span><\/li>\n<li><span style=\"color: #000000;\">Ong CJ, Hutch M, Smirnakis SM. The Effect of Ambient Light Conditions on Quantitative Pupillometry. Neurocrit Care 2019;30(2):316-321. PMID 30218349<\/span><\/li>\n<li><span style=\"color: #000000;\">Ong CJ, Hutch M, Barra M, Kim A, Zafar S, Smirnakis SM. Osmotic therapy effects on pupil reactivity: Quantification using pupillometry in critically ill neurologic patients. Neurocrit Care 2019;30(2):307-315. PMID 30298336<\/span><\/li>\n<li><span style=\"color: #000000;\">Chung DY, Olson DM, John S, Mohamed W, Kumar MA, Thompson BB, Rordorf GA. Evidence-Based Management of External Ventricular Drains. Curr Neurol Neurosci 2019 11 26; 19(12):94. PMID: 31773310.<\/span><\/li>\n<li><span style=\"color: #000000;\">Ibrahim MS, Samuel B, Mohamed W, Suchdev K. Cardiac Dysfunction in Neurocritical Care: An Autonomic Perspective. Neurocrit Care. 2019 06; 30(3):508-521. PMID:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30484009\" style=\"color: #000000;\">30484009<\/a><\/span><\/li>\n<li><span style=\"color: #000000;\">Chung DY, Olson DM, John S, Mohamed W, Kumar MA, Thompson BB, Rordorf GA. Evidence-Based Management of External Ventricular Drains. Curr Neurol Neurosci Rep. 2019 11 26; 19(12):94. PMID: 31773310.<\/span><\/li>\n<li><span style=\"color: #000000;\">Malak, W; Qureshi MM; Kiliany, R; Brahmbhatt, TS; Mian AZ and Takahashi, CE. Contribution of Brain MRI after Head CT in the Evaluation of Acute, Hospitalized Traumatic Brain Injury Patients: An Under-Utilized Resource? <em>Biomedical Journal of Scientific &amp; Technical Research<\/em>, March 2020: 20264-20269. DOI: 10.26717\/BJSTR.2020.26.004408<\/span><\/li>\n<li><span style=\"color: #000000;\">Cervantes-Arslanian A*, Lau, V*, Anand P, Shulman J, Ford T, Takahashi C, Daneshmand A, Nguyen T, Suchdev K, Abdennadher M, Saxena A, Macone A, Perloff M, Zhu S, Greer M. Rapid Development and Dissemination of Protocols for Managing Neurology Inpatients with COVID-19. <em>Ann Neurol.<\/em> 12 May 2020. PMID: 32395831.<\/span><\/li>\n<li><span style=\"color: #000000;\">Moloney PB, Hutchinson S, Heskin J, Mulcahy F, Langan Y, Conlon NP, Linas BP, Takahashi C, Cervantes-Arslanian AM. Possible N-methyl-D-aspartate receptor antibody-mediated encephalitis in the setting of HIV cerebrospinal fluid escape. J Neurol. 2020 May; 267(5):1348-1352. PMID:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31960135\" style=\"color: #000000;\">31960135<\/a><\/span><\/li>\n<li><span style=\"color: #000000;\">Shulman J, Jara H, Qureshi M, Lau H, Finn B, Abbas S, Cervantes-Arslanian AM, Mercado M, Greer D, Chapman M, Mian A, Takahashi CE. Perihematomal Edema Surrounding Spontaneous Intracerebral Hemorrhage by CT: Ellipsoidal vs. Morphometric Volumetry. <em>Medicine<\/em> (Baltimore). 2020 Jul 10;99(28):e20951. PMID: 32664097<\/span><\/li>\n<li><span style=\"color: #000000;\">Anand P, Zakaria A, Benameur K, Ong C, O\u2019Shea S, Putnam M, Greer D, Cervantes-Arslanian AM. Myoclonus in Patients with COVID-19: A Multicenter Case Series.<em> Crit Care Med.<\/em> 2020 Aug 14. PMID: 32804784<\/span><\/li>\n<li><span style=\"color: #000000;\">Nwajei F, Anand P, Abdalkader M, Andreu Arasa VC, Aparicio HJ, Behbahani S, Curiale G, Daneshmand A, Dasenbrock H, Mayo T, Mian A, Nguyen T, Ong C, Romero JRR, Sakai O, Takahashi C, Cervantes-Arslanian AM. Cerebral Venous Sinus Thromboses in Patients with SARS-Co-V Infection: Three Cases and a Review of the Literature. <em>J Stroke Cerebrovasc. Dis<\/em>. <em>2020. <\/em>PMID: 33254367<\/span><\/li>\n<li><span style=\"color: #000000;\">Greer DM, Shemie SD, Lewis A, Torrance S, Varelas P, Goldenberg FD, Bernat JL, Souter M, Topcuoglu MA, Alexandrov AW, Baldessari M, Bleck T, Citerio G, Dawson R, Hoppe A, Jacobe S, Manara A, Nakagawa TA, Pope TM, Silvester W, Thomson D, Al Rahma H, Badenes R, Baker AJ, Cerny V, Chang C, Chang TR, Gnedovskaya E, Han, M, Honeybul S, Jimenez E, Kuroda Y, Liu G, Mallick UK, Marquevich V, Mejia-Mantilla J, Piradov M, Quayyum S, Shrestha GS, Su Y, Timmons SD, Teitelbaum J, Videtta W, Zirpe K, Sung G. Determination of brain death\/death by neurologic criteria around the world: the world brain death project. <em>JAMA<\/em> 2020 Sep 15;324(11):1078-1097.<\/span><\/li>\n<li><span style=\"color: #000000;\">Migady I, Rae-Grant A, Greer DM. Brain death evaluation during the pandemic. <em>Neurology<\/em>. 2020 Oct 13;95(15);693-4.<\/span><\/li>\n<li><span style=\"color: #000000;\">Sharma M, Creutzfeldt CJ, Lewis A, Patel PV, Hartog C, Jannotta GE, Blissitt P, Kross EK, Kassenbaum N, Greer DM, Curtis JR, Wahlster S. Healthcare professionals\u2019 perceptions of critical care resources availability and factors associated with mental well-being during COVID-19: Results from a US survey. <em>Clin Infect Dis<\/em> 2020; Sep 2 [Epub ahead of print]<\/span><\/li>\n<li><span style=\"color: #000000;\">Anand P and Lau K.H. V, Chung D, Virmani D, Cervantes-Arslanian A, Mian A and Takahashi CE. Posterior Reversible Encephalopathy Syndrome in Patients with Coronavirus Disease 2019: Two Cases and a Review of The Literature. J Stroke Cerebrovasc Dis. 2020 Nov; 29 (11): 105212<\/span><\/li>\n<li><span style=\"color: #000000;\">Carneiro T, Dashkoff J, Leung LY, Nobleza COS, Marulanda-Londono E, Hathidara M Koch S, Sur N, Boske A, Voetsch B, Nour HA, Miller DJ,\u00a0 Daneshmand A, Shulman J, Curiale G, Greer DM, Romero JR, *Anand P, *Cervantes-Arslanian AM. Intravenous tPA for Acute Ischemic Stroke in Patients with COVID-19. <em>J Stroke Cerebrovasc. Dis<\/em>. 2020 Nov;29 (11): 105201. Epub 2020 Jul 27. PMCID: PMC7383245<\/span><\/li>\n<li><span style=\"color: #000000;\">Ong CJ, Orfanoudaki A, Zhang R, Caprasse FPM, Hutch M, MA L, Fard D, Balogun O, Miller M, Minnig M, Saglam H, Prescott B, Greer D, Smirnakis SM, Bertsimas D. Machine Learning and Natural Language Processing Methods to Identify Ischemic Stroke, Acuity and Location from Radiology Reports. Plos One. 2020;15(6): e0234908. PMID 32559211<\/span><\/li>\n<li><span style=\"color: #000000;\">Sugimoto K, Chung DY. Spreading Depolarizations and Subarachnoid Hemorrhage. Neurotherapeutics. 2020 04; 17(2):497-510. PMID: 32323204.<\/span><\/li>\n<li><span style=\"color: #000000;\">Janeway M; Zhao X; Rosenthaler M; Zuo Y; Balasubramaniyan K; Poulson M; Neufeld M, Siracuse J, Takahashi CE, Allee L; Dechert T; Burke P; Li F, Kalesan B. Clinical diagnostic phenotypes in hospitalization due to self-inflicted firearm injury. J Affect Disord. 2020 Sep 15; 278: 172-180. DOI: 10.1016\/j.jad.2020.09.067<\/span><\/li>\n<li><span style=\"color: #000000;\">Anand P, Zhou L, Bhadelia N, Hamer DH, Greer DM, Cervantes-Arslanian AM. Neurologic Findings Among Inpatients With COVID-19 at a Safety-net US Hospital. Neurol Clin Pract. 2021 Apr; 11(2):e83-e91. PMID: 33842075.<\/span><\/li>\n<li><span style=\"color: #000000;\">Sader E, Abdalkader M, Thom N, Nguyen TN, McDonald S, Greer D, Brown SC, Mohamedali A, Gutierrez J, Shi H, Morris J, Lopez-Rivera V, Sheth SA, Sloane KL, Singhal A, Atchaneeyasakul K, Liebeskind DS, Khandelwal P, Bach I, Raz E, Cervantes-Arslanian AM. Endovascular Treatment of Infective Endocarditis-Related Acute Large Vessel Occlusion Stroke. <em>J Stroke Cerebrovasc Dis.<\/em> 2021 Apr 08; 30(6):105775. PMID: 33839380<\/span><\/li>\n<li><span style=\"color: #000000;\">Nadjarian A, LeClair J, Mahoney TF, Awtry EH, Bhatia JS, Caruso LB, Clay A, Greer D, Hingorani KS, Horta LFB, Ibrahim M, Ieong MH, James T, Kulke MH, Lim R, Lowe RC, Moses JM, Murphy J, Nozari A, Patel AD, Silver B, Theodore AC, Wang RS, Weinstein E, Wilson SA, Cervantes-Arslanian AM. Validation of a Crisis Standards of Care Model for Prioritization of Limited Resources During the Coronavirus Disease 2019 Crisis in an Urban, Safety-Net, Academic Medical Center. <em>Crit Care Med.<\/em> 2021 Jun 09. PMID: 34115635.<\/span><\/li>\n<li><span style=\"color: #000000;\">Carneiro T, Spears W, LeClair J, Mahoney T, Takahashi C, Cervantes-Arslanian A. Admission Lymphocytopenia is Associated with Urinary Tract Infection and Nosocomial Infections in Hemorrhagic Stroke. <em>J Stroke Cerebrovasc Dis<\/em>. 2021 Sep 03; 30(11):106079. PMID: 34488005.<\/span><\/li>\n<li><span style=\"color: #000000;\">Arandela K, Samudrala S, Abdalkader M, Anand P, Daneshmand A, Dasenbrock H, Nguyen T, Ong C, Takahashi C, Shulman J, Babi MA, Sivakumar S, Shah N, Jain S, Anand S, Nobleza COS, Shekhar S, Venkatasubramanian C, Salahuddin H, Taqi MA, Nour HA, Nofar JB, Cervantes-Arslanian AM. Reversible Cerebral Vasoconstriction Syndrome in Patients with Coronavirus Disease: A Multicenter Case Series. <em>J Stroke Cerebrovasc Dis.<\/em> 2021 Sep 17; 30(12):106118. PMID: 34560378.<\/span><\/li>\n<li><span style=\"color: #000000;\">Sasanejad P, Hezarkhani LA, Arsang-Jang S, Tsivgoulis G, Ghoreishi A, Kristian B, Rahmig J, Farhoudi M, Hokmabadi ES, Borhani-Haghighi A, Sariaslani P, Sharifi-Razavi A, Ghandehari K, Khosravi A, Smith C, Nilanont Y, Akbari Y, Nguyen TN, Bersano A, Yassi N, Yoshimoto T, Lattanzi S, Gupta A, Zand R, Rafie S, Mousavian SP, Shahsavaripour MR, Amini S, Kamenova SU, Kondybayeva A, Zhanuzakov M, Macri EM, Nobleza COS, Ruland S, Cervantes-Arslanian AM, Desai MJ, Ranta A, Ahmadi AM, Rostamihosseinkhani M, Foroughi R, Hooshmandi E, Akhoundi FH, Shuaib A, Liebeskind, DS, Siegler J, Romano JG, Mayer SA, Shahripour RB, Zamani B, Woolsey A, Fazli Y, Mojtaba K, Isaac CF, Biller J, Di Napoli M, Azarpazhooh MR. Safety and Outcomes of Intravenous Thrombolytic Therapy in Ischemic Stroke Patients with COVID-19: CASCADE Initiative,<em> J Stroke Cerebrovasc Dis. <\/em>30(12). 2021.<\/span><\/li>\n<li><span style=\"color: #000000;\">Sreekrishnan A, Ong CJ, Mahajan R, Prescott B, Smirnakis SM, Bevers MB, Feske SK, Snider SB. Subcortical Sparing Associated with Ambulatory Independence after Hemicraniectomy for Malignant Infarction. J Stroke Cerebrovasc Dis. 2021;30(8):1015850. PMID: 34000606.<\/span><\/li>\n<li><span style=\"color: #000000;\">Prescott BR, Saglam H, Duskin J, Miller MI, Thakur AS, Gholap EA, Hutch MR, Smirnakis SM, Zafar SF, Dupuis J, Benjamin EJ, Greer DM, Ong CJ. Anisocoria and Poor Pupil Reactivity by Quantitative Pupillometry in Patients with Intracranial Pathology. Critical Care Medicine, 2021. doi: 10.1097\/CCM.0000000000005272.<\/span><\/li>\n<li><span style=\"color: #000000;\">Chung DY, Thompson BB, Kumar MA, Mahta A, Rao SS, Lai JH, Tadevosyan A, Kessler K, Locascio JJ, Patel AB, Mohamed W, Olson DM, John S, Rordorf GA. Association of External Ventricular Drain Wean Strategy with Shunt Placement and Length of Stay in Subarachnoid Hemorrhage: A Prospective Multicenter Study. Neurocrit Care. 2021 Sep 08. PMID: 34498207.<\/span><\/li>\n<li><span style=\"color: #000000;\">Bernier TD, Schontz MJ, Izzy S, Chung DY, Nelson SE, Leslie-Mazwi TM, Henderson GV, Dasenbrock H, Patel N, Aziz-Sultan MA, Feske S, Du R, Abulhasan YB, Angle MR. Treatment of Subarachnoid Hemorrhage-associated Delayed Cerebral Ischemia With Milrinone: A Review and Proposal. J Neurosurg Anesthesiol. 2021 Jul 01; 33(3):195-202. PMID: 33480639.<\/span><\/li>\n<li><span style=\"color: #000000;\">Chung DY, Abdalkader M, Nguyen TN. Aneurysmal Subarachnoid Hemorrhage. Neurol Clin. 2021 05; 39(2):419-442. PMID: 33896527.<\/span><\/li>\n<li><span style=\"color: #000000;\">Chung DY, Oka F, Jin G, Harriott A, Kura S, Aykan SA, Qin T, Edmiston WJ, Lee H, Yaseen MA, Sakad\u017eic S, Boas DA, Whalen MJ, Ayata C. Subarachnoid hemorrhage leads to early and persistent functional connectivity and behavioral changes in mice. J Cereb Blood Flow Metab. 2021 05; 41(5):975-985. PMID: 32936728.<\/span><\/li>\n<li><span style=\"color: #000000;\">Lau KHV, Hamlyn E, Williams TJ, Qureshi MM, Mak K, Mian A, Cervantes-Arslanian A, Zhu S, Takahashi C. The Effects of Video Instruction on Neuroscience Intensive Care Unit Nursing Skills in Case Presentations and Neurological Examinations. <em>J Neurosci Nurs.<\/em> 2021 Apr 08. PMID: 33840806.<\/span><\/li>\n<li><span style=\"color: #000000;\">Lau KHV, Anand P, Greer DM, Cervantes-Arslanian A, Phicil S, Moore J, Takahashi C. Leveraging Trends in Neurology Admissions for Departmental Planning During the COVID-19 Pandemic. <em><\/em> 2021 Apr; 11(2):125-130. PMID: 33791055.<\/span><\/li>\n<li><span style=\"color: #000000;\">Zhou SE, Barden MM, Gilmore EJ, Pontes-Neto OM, Sampaio Silva G, Kurtz P, Oliveira-Filho J, Cougo-Pinto PT, Zampieri FG, Napoli NJ, Theriot JJ, Greer DM, Maciel CB. Postcardiac arrest neuroprognostication practices: A survey of Brazilian physicians. <em>Crit Care Explor<\/em> 2021 Jan 11;3(1):e0321.<\/span><\/li>\n<li><span style=\"color: #000000;\">Greer DM, Moeller J, Torres DR, Soni M, Cruz S, Tornes L, Patwa H, Gutmann L, Sacco R, Galetta S. Funding the educational mission in neurology. <em>Neurology<\/em> 2021 Mar 23;96(12):574-82.<\/span><\/li>\n<li><span style=\"color: #000000;\">Greer DM, Ritter J, Helbok R, Badjatia N, Ko SB, Guanci M, Sheth KN. Impact of Fever Prevention in Brain-Injured Patients (INTREPID): Study Protocol for a Randomized Controlled Trial. <em>Neurocrit Care<\/em> 2021 Mar 24 [Online ahead of print]<\/span><\/li>\n<li><span style=\"color: #000000;\">Lewis A, Kumpfbeck A, Liebman J, Shemie SD, Sung G, Torrance S, Greer D. Barriers to the Use of Neurologic Criteria to Declare Death in Africa. <em>Am J Hosp Palliat Care<\/em>. 2021 Mar 30 [Online ahead of print]<\/span><\/li>\n<li><span style=\"color: #000000;\">Migdady I, Amin M, Shoskes A, Hassett C, Rae-Grant A, Snider SB, Greer DM, Cho SM, George P. Outcomes, Time-Trends, and Factors Associated with Ancillary Study Use for the Determination of Brain Death. <em>Crit Care Med<\/em> 2021 Apr 12 [Online ahead of print]<\/span><\/li>\n<li><span style=\"color: #000000;\">Francoeur C, Weiss MJ, Macdonald JM, Press C, Greer DM, Berg RA, Topjian AA, Morrison W, Kirschen MP. Variability in Pediatric Brain Death Determination Protocols in the United States. <em>Neurology<\/em> 2021 May 28 [Online ahead of print]<\/span><\/li>\n<li><span style=\"color: #000000;\">Beekman R, Maciel CB, Ormseth CH, Zhou SE, Galluzzo D, Miyares LC, Torres-Lopez VM, Payabvash S, Mak A, Greer DM, Gilmore EJ. Early head CT in post-cardiac arrest patients: a helpful tool or contributor to self-fulfilling prophecy? <em>Resuscitation<\/em>. 2021 Aug;165:68-76.<\/span><\/li>\n<li><span style=\"color: #000000;\">Kurtz P, Storm C, Soares M, Bozza F, Maciel CB, Greer DM, Bastos LSL, Melo U, Mazza B, Santino MS, Seabra Lannes R, de Moraes APP, Passos JT, Moralez GM, Santos RC, Machado MM, Saturnino SF, Mendes CL, Oswaldo Vianna A, Salluh J. Clinical Characteristics and In-Hospital Mortality of Cardiac Arrest Survivors in Brazil: A Large Retrospective Multicenter Cohort Study. <em>Crit Care Explor<\/em>. 2021 Jul 14;3(7):e0479.<\/span><\/li>\n<li><span style=\"color: #000000;\">Farris C, Baghdanian A, Takahashi CE, Sung E, Sakai O, Patel MN, Burley H, Rai Aayushi, Brahmbhatt T, Adran D, Kim H, Ravilla A, Mian A.\u00a0 Implementation of Institutional Triaging Algorithms Decreases Head and Neck MDCT Usage in Blunt Trauma.\u00a0 Radiology (Accepted, in press).<\/span><\/li>\n<li><span style=\"color: #000000;\">Zhou SE, Barden MM, Gilmore EJ, Pontes-Neto OM, Sampaio Silva G, Kurtz P, Oliveira-Filho J, Cougo-Pinto PT, Zampieri FG, Napoli NJ, Theriot JJ, Greer DM, Maciel CB. Postcardiac arrest neuroprognostication practices: A survey of Brazilian physicians. <em>Crit Care Explor<\/em> 2021 Jan 11;3(1):e0321.<\/span><\/li>\n<li><span style=\"color: #000000;\">Charidimou A, Samudrala S, Cervantes-Arslanian AM, Sloan JM, Dasenbrock HH, Daneshmand A. Vaccine-Induced Immune Thrombotic Thrombocytopenia with Concurrent Arterial and Venous Thrombi Following Ad26.COV2.S Vaccination. J Stroke Cerebrovasc Dis. 2021 Sep 18; 30(12):106113.PMID:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/34547677\" style=\"color: #000000;\">34547677<\/a><\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Division of Neurocritical Care provides care for critically ill patients with a wide variety of neurologic emergencies.\u00a0 Our research parallels illnesses most frequently affecting our patient population with a focus on brain death, coma post-cardiac arrest, traumatic brain injury, neurologic infections including COVID-19 and infectious endocarditis, and development of tools for early identification of [&hellip;]<\/p>\n","protected":false},"author":935,"featured_media":0,"parent":7222,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/neurology\/wp-json\/wp\/v2\/pages\/7615"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/neurology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/neurology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/neurology\/wp-json\/wp\/v2\/users\/935"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/neurology\/wp-json\/wp\/v2\/comments?post=7615"}],"version-history":[{"count":7,"href":"https:\/\/www.bumc.bu.edu\/neurology\/wp-json\/wp\/v2\/pages\/7615\/revisions"}],"predecessor-version":[{"id":7624,"href":"https:\/\/www.bumc.bu.edu\/neurology\/wp-json\/wp\/v2\/pages\/7615\/revisions\/7624"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/neurology\/wp-json\/wp\/v2\/pages\/7222"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/neurology\/wp-json\/wp\/v2\/media?parent=7615"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}