Ludy Shih, MD, MMSc

Dr. Ludy Shih is board-certified in Neurology. After receiving her medical degree from the University of California School of Medicine, Los Angeles, she completed her internship, Neurology residency and Movement Disorders fellowship at Harvard/Beth Israel Deaconess Medical Center (BIDMC) in Boston. Prior to joining the Movement Disorders section at BUMC Dr. Shih was on faculty of Harvard Medical School as Assistant Professor of Neurology and Director of the Deep Brain Stimulation Program at BIDMC.

Dr. Shih has been named the director of the Deep Brain Stimulation Program at BUMC and is actively engaged in teaching, patient care and clinical research. 

In April 2020 Dr Shih was appointed as Director of Neurology Research Education.

Special Interests: Movement Disorders, Parkinson’s disease, Essential Tremor, Dystonia, Deep Brain Stimulation, Gait disorders, Tremor, Motor Physiology, Digital biomarkers, Wearable Sensors, Drug Development, Clinical Outcomes, Research Education

Publications:

Schneider RB, Jimenez-Shahed J, Abraham DS, Thibault DP, Mantri S, Fullard M, Burack MA, Chou KL, Spindler M, Jermakowicz WJ, D’Haese PF, York MK, Kirk JC, Schwalb JM, Espay AJ, Shih LC, Simon DK, Hunter C, Crispo JAG, Willis AW; of the Parkinson Study Group Health Care Outcomes and Disparities Working Group (HCODWG) and the Registry to Advance DBS for PD (RAD-PD). Acute readmission following deep brain stimulation surgery for Parkinson’s disease: A nationwide analysis. Parkinsonism Relat Disord. 2019; in press. doi: 10.1016/j.parkreldis.2019.11.023.

Joutsa J*, Shih LC* (co-first), Fox MD. Mapping Holmes’ tremor circuit using the human brain connectome. Ann Neurol. 2019 Oct 15. doi: 10.1002/ana.25618.

Broom L, Worley A, Gao F, Hernandez L, Ashton C, Shih L, and VanderHorst V. Translational methods to detect asymmetries in temporal and spatial walking metrics in parkinsonian mouse models and human subjects with Parkinson’s disease. Scientific Reports 2019; doi.org/10.1038/s41598-019-38623-6.

Joutsa J*, Shih LC* (co-first), Horn A, Reich M, Hsu J, Wu O, Rost NS, Fox MD. Identifying therapeutic targets from spontaneous beneficial brain lesions. Ann Neurol 2018; 84: 153-157.

Elble RJ, Shih L, Cozzens JW. Surgical treatments for essential tremor. Expert Rev Neurother. 2018 Apr;18(4):303-321.

Ondo W, Hashem V, LeWitt PA, Pahwa R, Shih L, Tarsy D, Zesiewicz T, Elble R.Comparison of the Fahn-Tolosa-Marin Clinical Rating Scale and the Essential Tremor Rating Assessment Scale. Mov Disord Clin Pract. 2017 Nov 23;5(1):60-65.

Shih LC and Pascual-Leone A. Noninvasive brain stimulation for essential tremor. Tremor and Other Hyperkinetic Disorders 2017; doi: 10.7916/D8G44W01.

Beck CA, Beran DB, Biglan KM, Boyd CM, Dorsey ER, Schmidt PN, Simone R, Willis AW, Galifianakis NB, Katz M, Tanner CM, Dodenhoff K, Aldred J, Carter J, Fraser A, Jimenez-Shahed J, Hunter C, Spindler M, Reichwein S, Mari Z, Dunlop B, Morgan JC, McLane D, Hickey P, Gauger L, Richard IH, Mejia NI, Bwala G, Nance M, Shih LC, Singer C, Vargas-Parra S, Zadikoff C, Okon N, Feigin A, Ayan J, Vaughan C, Pahwa R, Dhall R, Hassan A, DeMello S, Riggare SS, Wicks P, Achey MA, Elson MJ, Goldenthal S, Keenan HT, Korn R, Schwarz H, Sharma S, Stevenson EA, Zhu W; Connect.Parkinson Investigators. National randomized controlled trial of virtual house calls for Parkinson disease. Neurology. 2017 Sep 12;89(11):1152-1161.

Broom L, Ellison B, Wagenaar L, Worley A, Soerberg E, Ashton C, Bennett D, Buchman A, Saper C, Shih L, Hausdorff J, and VanderHorst V. A translational approach to capture gait signatures of neurological disorders in mice and humans. Scientific Reports 2017; doi:10.1038/s41598-017-03336-1.

Horn A, Kühn AA, Merkl A, Shih L, Alterman R, Fox M. Probabilistic conversion of neurosurgical DBS electrode coordinates into MNI space. NeuroImage 2017; 150: 395-404.

Graebner AK, Tarsy D, Shih LC, Vanderhorst V, Kulkarni O, Kaplan S, Simon DK. Clinical impact of 123I-Ioflupane SPECT (DaTscan) in a movement disorders center. Neurodegen Diseases 2017; 17: 38-43.

Rossi PJ, Gunduz A, Judy J, Wilson L, Machado A, Giordano JJ, Elias WJ, Rossi MA, Butson CL, Fox MD, McIntyre CC, Pouratian N, Swann NC, de Hemptinne C, Gross RE, Chizeck HJ, Tagliati M, Lozano AM, Goodman W, Langevin JP, Alterman RL, Akbar U, Gerhardt GA, Grill WM, Hallett M, Herrington T, Herron J, van Horne C, Kopell BH, Lang AE, Lungu C, Martinez-Ramirez D, Mogilner AY, Molina R, Opri E, Otto KJ, Oweiss KG, Pathak Y, Shukla A, Shute J, Sheth SA, Shih LC, Steinke GK, Tröster AI, Vanegas N, Zaghloul KA, Cendejas-Zaragoza L, Verhagen L, Foote KD, Okun MS. Proceedings of the Third Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies. Front Neurosci. 2016;10:119.

Norris SA, Jinnah HA, Espay AJ, Klein C, Brüggemann N, Barbano RL, Malaty I, Rodriguez RL, Vidailhet M, Roze E, Reich SG, Berman BD, LeDoux MS, Pirio Richardson S, Agarwal P, Mari Z, Ondo W, Shih LC, Fox S, Berardelli A, Testa CM, Chang FCF, TroungD, Nahab F, Xie T, Hallett M, Rosen R, Wright LJ, Perlmutter JS. Clinical and Demographic Characteristics Related to Onset Site and Spread of Cervical Dystonia. Mov Disord 2016; 31:1874-1882.

Gibbons C, Garcia J, Wang N, Shih LC, and Freeman R. The diagnostic discrimination of cutaneous alpha-synuclein deposition in Parkinson disease. Neurology 2016;87(5):505-12.

Dorsey ER, Achey MA, Beck CA, Beran DB, Biglan KM, Boyd CM, Schmidt PN, Simone R, Willis AW, Galifianakis NB, Katz M, Tanner CM, Dodenhoff K, Ziman N, Aldred J, Carter J, Jimenez-Shahed J, Hunter C, Spindler M, Mari Z, Morgan JC, McLane D, Hickey P, Gauger L, Richard IH, Bull MT, Mejia NI, Bwala G, Nance M, Shih L, Anderson L, Singer C, Zadikoff C, Okon N, Feigin A, Ayan J, Vaughan C, Pahwa R, Cooper J, Webb S, Dhall R, Hassan A, Weis D, DeMello S, Riggare SS, Wicks P, Smith J, Keenan HT, Korn R, Schwarz H, Sharma S, Stevenson EA, Zhu W. National Randomized Controlled Trial of Virtual House Calls for People with Parkinson’s Disease: Interest and Barriers. Telemed J E Health. 2016; 22:590-8.

Gunduz A, Morita H, Rossi PJ, Allen WL, Alterman RL, Bronte-Stewart H, Butson CR, Charles D, Deckers S, de Hemptinne C, DeLong M, Dougherty D, Ellrich J, Foote KD, Giordano J, Goodman W, Greenberg BD, Greene D, Gross R, Judy JW, Karst E, Kent A, Kopell B, Lang A, Lozano A, Lungu C, Lyons KE, Machado A, Martens H, McIntyre C, Min H, Neimat J, Ostrem J, Pannu S, Ponce F, Pouratian N, Reymers D, Schrock L, Sheth S, Shih L, Stanslaski S, Steinke GK, Stypulkowski P, Tröster AI, Verhagen L, Walker H, Okun MS. Proceedings of the Second Annual Deep Brain Stimulation Think Tank: What’s in the Pipeline. Int J Neurosci. 2015;125(7):475-85.

Lee SI, Daneault JF, Golabchi FN, Patel S, Paganoni S, Shih L, Bonato P. A novel method for assessing the severity of levodopa-induced dyskinesia using wearable sensors. Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:8087-90.

Parihar R, Alterman R, Papavassiliou E, Tarsy D, Shih LC. Comparison of VIM and STN DBS for Parkinsonian Resting and Postural/Action Tremor. Tremor Other Hyperkinet Mov (N Y). 2015 Jul 6;5:321.

Sarkar SN, Papavassiliou E, Hackney DB, Alsop DC, Shih LC, Madhuranthakam AJ, Busse RF, La Ruche S, Bhadelia RA. Three-dimensional brain MRI for DBS patients within ultra-low radiofrequency power limits. Mov Disord. 2014 Jan 17. doi: 10.1002/mds.25808.

Shih LC, Vanderhorst VG, Lozano AM , Hamani C, Moro E. Improvement of Pisa syndrome with contralateral pedunculopontine stimulation. Mov Disord 2013; 28: 555-6.

Kulkarni OC, Czarnecki K, Papavassiliou E, Tarsy D, Shih LC. Complex parkinsonian tremor requiring combined ViM and STN stimulation (DBS). Mov Disord 2013; 28: 554.

Smith KM, O’Connor M, Papavassiliou E, Tarsy D, Shih LC. Phonemic verbal fluency decline after subthalamic nucleus deep brain stimulation does not depend on number of microelectrode recordings or lead tip placement. Parkinsonism Relat Disord 2014;20(4):400-4.

Shih LC, Tarsy D, Okun MS. The current state and needs of North American movement disorders fellowship training programs. Parkinsons Dis 2013; 2013:701426.

Shih LC, LaFaver K, Lim C, Papavassiliou E, Tarsy D. Loss of benefit in VIM thalamic deep brain stimulation (DBS) for essential tremor (ET): how prevalent is it? Parkinsonism Relat Disord 2013; 19:676-9.

Shih LC, Piel J, Warren A, Kraics L, Silver A, Vanderhorst V, Simon DK, Tarsy D. Singing in Groups for Parkinson’s Disease (SING-PD): A pilot study of group singing therapy for PD-related voice / speech disorders. Parkinsonism Relat Disord 2012; 18: 548-552.

Shih LC, Vanderhorst V, Papavassiliou E, Tarsy D. Sustained dyskinesias following elective cessation and reactivation of chronic STN DBS for a surgical procedure. Neuromodulation. 2011; 14:512-4.

Shih LC and Tarsy D. Survey of US neurologists’ attitudes towards deep brain stimulation for Parkinson’s disease. Neuromodulation. 2011; 14:208-13.

Patel S, Chen BR, Mancinelli C, Paganoni S, Shih L, Welsh M, Dy J, Bonato P. Longitudinal monitoring of patients with Parkinson’s disease via wearable sensor technology in the home setting. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:1552-5.

Chen BR, Patel S, Buckley T, Rednic R, McClure DJ, Shih L, Tarsy D, Welsh M, Bonato P. A web-based system for home monitoring of patients with Parkinson’s disease using wearable sensors. IEEE Trans Biomed Eng. 2011; 831-6.

Patel S, Chen BR, Buckley T, Rednic R, McClure D, Tarsy D, Shih L, Dy J, Welsh M, Bonato P. Home monitoring of patients with Parkinson’s disease via wearable technology and a web-based application. Conf Proc IEEE Eng Med Biol Soc. 2010;2010:4411-4.

Ekstein D, Shih LC, Sheen V. Focal botulinum toxin injections lead to rapid resolution of myogenic artifact during EEG monitoring. JNNP. 2010; 81:637-8.

Vanderhorst VG, Papavassiliou E, Tarsy D, Shih L. Early brain abscess: A rare complication of deep brain stimulation. Mov Disord. 2009; 24:1395-1397.

Lungu C, Aia PG, Shih LC, Esper CD, Factor SA, Tarsy D. Tardive dyskinesia due to aripiprazole: report of 2 cases. J Clin Psychopharmacol. 2009; 29:185-6.

Shih LC and Tarsy D. Deep brain stimulation for the treatment of atypical parkinsonism. Movement Disorders. 2007; 22:2149-55.

Shih LC, Saver JL, Alger JR, Starkman S, Leary MC, Vinuela F, Duckwiler G, Gobin YP, Jahan R, Villablanca JP, Vespa PM, Kidwell CS. Perfusion-weighted magnetic resonance imaging thresholds identifying core, irreversibly infarcted tissue. Stroke. 2003; 34:1425-30.