{"id":15,"date":"2002-11-23T06:10:19","date_gmt":"2002-11-23T10:10:19","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/msr\/research-topics\/lipid-antigens-for-tuberculosis\/"},"modified":"2012-07-29T00:33:28","modified_gmt":"2012-07-29T04:33:28","slug":"lipid-antigens-for-tuberculosis","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/msr\/research-topics\/lipid-antigens-for-tuberculosis\/","title":{"rendered":"Lipid Antigens for Tuberculosis"},"content":{"rendered":"<p><strong>CD1c-mediated T-cell recognition of isoprenoid glycolipids in <em>Mycobacterium tuberculosis<\/em> infection<\/strong><\/p>\n<p>A collaboration in immunology&#8230;<\/p>\n<p><img loading=\"lazy\" border=\"0\" src=\"https:\/\/www.bumc.bu.edu\/msr\/files\/Images\/small_nature.jpg\" width=\"316\" height=\"443\" alt=\"lipid antigens nature cover\" \/><\/p>\n<p><em>A recent article collaborating with Prof. Branch Moody<\/em><\/p>\n<p>Mass Spectrometry was used to identify and structurally define a previously unknown lipid antigen isolated from tuberculosis bacteria.&nbsp; Both low energy CID MS\/MS and high energy CID with accurate mass measurement were used for determination of the pseudo-isoprenoid structure of the lipid chain.&nbsp; The structure of the saccharide moiety was determined by permethylation followed by GCMS for determination of the substitution pattern.&nbsp;&nbsp;<\/p>\n<p>For more information, please visit <a href=\"http:\/\/www.nature.com\" target=\"blank\">www.nature.com<\/a>, or contact <a href=\"mailto:cecmsms@bu.edu\">Cathy Costello<\/a> for reprints.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection A collaboration in immunology&#8230; A recent article collaborating with Prof. Branch Moody Mass Spectrometry was used to identify and structurally define a previously unknown lipid antigen isolated from tuberculosis bacteria.&nbsp; Both low energy CID MS\/MS and high energy CID with accurate mass measurement were used [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":6,"menu_order":16,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/msr\/wp-json\/wp\/v2\/pages\/15"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/msr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/msr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/msr\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/msr\/wp-json\/wp\/v2\/comments?post=15"}],"version-history":[{"count":1,"href":"https:\/\/www.bumc.bu.edu\/msr\/wp-json\/wp\/v2\/pages\/15\/revisions"}],"predecessor-version":[{"id":1656,"href":"https:\/\/www.bumc.bu.edu\/msr\/wp-json\/wp\/v2\/pages\/15\/revisions\/1656"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/msr\/wp-json\/wp\/v2\/pages\/6"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/msr\/wp-json\/wp\/v2\/media?parent=15"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}