{"id":1982,"date":"2018-06-15T10:14:02","date_gmt":"2018-06-15T14:14:02","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/medlib\/?page_id=1982"},"modified":"2018-07-27T16:18:58","modified_gmt":"2018-07-27T20:18:58","slug":"ebm-intro-p13","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/medlib\/resources\/tutorials\/introduction-to-evidence-based-medicine\/ebm-intro-p13\/","title":{"rendered":"Why Practice EBM?"},"content":{"rendered":"<h2><\/h2>\n<p><img loading=\"lazy\" src=\"\/medlib\/files\/2018\/06\/types_sm_unfil.jpg\" width=\"125\" height=\"212\" alt=\"\" border=\"0\" align=\"left\" style=\"display: inline; margin: 2px 2px 2px 5px;\" \/><\/p>\n<h4>PROBLEM: Lack of familiarity with primary research can result in unnecessary clinical trials and possible harm to research subjects<sup>1<\/sup><\/h4>\n<ul>\n<li><span class=\"bold\">FACT:<\/span><span>\u00a0<\/span>64 clinical trials involving the drug Aprotinin between 1987 and 2002 continuously found that the drug lessened bleeding during surgery, but only 20% of previous studies were cited by researchers.<sup>2<\/sup><span>\u00a0<\/span>Because later researchers were unaware of research that came before, they may have denied a proven therapy to a control group.<\/li>\n<li><span class=\"bold\">EBM SOLUTION:<\/span><span>\u00a0<\/span>A careful and critical literature review should be carried out prior to engaging in clinical research.<\/li>\n<li><span class=\"bold\">EBM RESOURCE:<\/span><span>\u00a0<\/span>Medline (<a href=\"http:\/\/www-ncbi-nlm-nih-gov.ezproxy.bu.edu\/sites\/entrez?otool=mabummlib\">PubMed<\/a>) searching with the results limited to Clinical Trials will provide a fairly complete representation of previously completed clinical research.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>1. Brown D.<span>\u00a0<\/span><a href=\"http:\/\/www.washingtonpost.com\/wp-dyn\/content\/article\/2006\/01\/01\/AR2006010100749_pf.html\" target=\"_blank\" rel=\"noopener\">Superfluous Medical Studies Called Into Question<\/a>. Washington Post. 2006 Jan 2; Sect. A:6.<\/p>\n<p>2. Fergusson D, Glass KC, Hutton B, Shapiro S.<span>\u00a0<\/span><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=PureSearch&amp;db=pubmed&amp;details_term=16279145%5BUID%5D\" target=\"_blank\" rel=\"noopener\">Randomized controlled trials of aprotinin in cardiac surgery: could clinical equipoise have stopped the bleeding?<\/a>. Clin Trials. 2005;2(3):218-29; discussion 229-32.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: right;\"><a href=\"https:\/\/www.bumc.bu.edu\/medlib\/resources\/tutorials\/introduction-to-evidence-based-medicine\/ebm-intro-p14\/\">Continue<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>PROBLEM: Lack of familiarity with primary research can result in unnecessary clinical trials and possible harm to research subjects1 FACT:\u00a064 clinical trials involving the drug Aprotinin between 1987 and 2002 continuously found that the drug lessened bleeding during surgery, but only 20% of previous studies were cited by researchers.2\u00a0Because later researchers were unaware of research [&hellip;]<\/p>\n","protected":false},"author":9631,"featured_media":0,"parent":1914,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/no-sidebars.php","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/medlib\/wp-json\/wp\/v2\/pages\/1982"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/medlib\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/medlib\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/medlib\/wp-json\/wp\/v2\/users\/9631"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/medlib\/wp-json\/wp\/v2\/comments?post=1982"}],"version-history":[{"count":5,"href":"https:\/\/www.bumc.bu.edu\/medlib\/wp-json\/wp\/v2\/pages\/1982\/revisions"}],"predecessor-version":[{"id":4183,"href":"https:\/\/www.bumc.bu.edu\/medlib\/wp-json\/wp\/v2\/pages\/1982\/revisions\/4183"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/medlib\/wp-json\/wp\/v2\/pages\/1914"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/medlib\/wp-json\/wp\/v2\/media?parent=1982"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}