{"id":11500,"date":"2018-12-18T14:39:03","date_gmt":"2018-12-18T19:39:03","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/medicine\/?p=11500"},"modified":"2018-12-18T14:41:21","modified_gmt":"2018-12-18T19:41:21","slug":"discovery-of-the-month-dec-2018","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/medicine\/2018\/12\/18\/discovery-of-the-month-dec-2018\/","title":{"rendered":"Discovery of the Month: Dec 2018"},"content":{"rendered":"<h3>&#8220;Retinoic Acid Signaling is Essential for Airway Smooth Muscle Homeostasis&#8221;<\/h3>\n<p class=\"author-list\"><a class=\"author-affiliation show-more\" data-dropdown=\"author-affiliation-0\" aria-expanded=\"false\"><img loading=\"lazy\" src=\"\/medicine\/files\/2018\/12\/Felicia-Chen.jpg\" alt=\"\" width=\"92\" height=\"92\" class=\"wp-image-11502 alignleft\" srcset=\"https:\/\/www.bumc.bu.edu\/medicine\/files\/2018\/12\/Felicia-Chen.jpg 184w, https:\/\/www.bumc.bu.edu\/medicine\/files\/2018\/12\/Felicia-Chen-150x150.jpg 150w, https:\/\/www.bumc.bu.edu\/medicine\/files\/2018\/12\/Felicia-Chen-100x100.jpg 100w\" sizes=\"(max-width: 92px) 100vw, 92px\" \/>Felicia Chen,\u00a0<\/a><a class=\"author-affiliation show-more\" data-dropdown=\"author-affiliation-1\" aria-expanded=\"false\">Fengzhi Shao,\u00a0<\/a><a class=\"author-affiliation show-more\" data-dropdown=\"author-affiliation-2\" aria-expanded=\"false\">Anne Hinds,\u00a0<\/a><a class=\"author-affiliation show-more\" data-dropdown=\"author-affiliation-3\" aria-expanded=\"false\">Sean Yao,\u00a0<\/a><a class=\"author-affiliation show-more\" data-dropdown=\"author-affiliation-4\" aria-expanded=\"false\">Sumati Ram-Mohan,\u00a0<\/a><a class=\"author-affiliation show-more\" data-dropdown=\"author-affiliation-5\" aria-expanded=\"false\">Timothy A. Norman,\u00a0<\/a><a class=\"author-affiliation show-more\" data-dropdown=\"author-affiliation-6\" aria-expanded=\"false\">Ramaswamy Krishnan,\u00a0and\u00a0<\/a><a class=\"author-affiliation show-more\" data-dropdown=\"author-affiliation-7\" aria-expanded=\"false\">Alan Fine<\/a><a class=\"author-affiliation show-more\" data-dropdown=\"author-affiliation-0\" aria-expanded=\"false\"><\/a><\/p>\n<p class=\"author-list\"><a class=\"author-affiliation show-more\" data-dropdown=\"author-affiliation-0\" aria-expanded=\"false\">Team led by <strong>Dr. Felicia Chen of the BU Pulmonary Center<\/strong> demonstrates that<span>\u00a0&#8220;Retinoic Acid signaling maintains airway smooth muscle homeostasis by preventing excessive activation of the TGF-\u03b2 pathway. We conclude that tonic RA signaling is critical for postnatal airway health.&#8221;<\/span><\/a><\/p>\n<p><img loading=\"lazy\" src=\"\/medicine\/files\/2018\/12\/Discovery-of-the-month-442x300.png\" alt=\"\" width=\"444\" height=\"301\" class=\"wp-image-11501 aligncenter\" srcset=\"https:\/\/www.bumc.bu.edu\/medicine\/files\/2018\/12\/Discovery-of-the-month-442x300.png 442w, https:\/\/www.bumc.bu.edu\/medicine\/files\/2018\/12\/Discovery-of-the-month-768x521.png 768w, https:\/\/www.bumc.bu.edu\/medicine\/files\/2018\/12\/Discovery-of-the-month.png 787w\" sizes=\"(max-width: 444px) 100vw, 444px\" \/><\/p>\n<p><a href=\"https:\/\/insight.jci.org\/articles\/view\/120398\">Read Full Article<\/a><\/p>\n<p><a href=\"https:\/\/bostonmedical.app.box.com\/s\/qbhdepwmp5n60kevdlz9a8gudrxs78jt\/file\/367991872219\">Presented by Dr. Chen at Grand Rounds, December 14, 2018<\/a><\/p>\n<p>This is the first installment in the Dept of Medicine series, <em>Discovery of the Month<\/em>. Recent projects are recognized and featured during a special monthly grand rounds for significant findings and publications.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;Retinoic Acid Signaling is Essential for Airway Smooth Muscle Homeostasis&#8221; Felicia Chen,\u00a0Fengzhi Shao,\u00a0Anne Hinds,\u00a0Sean Yao,\u00a0Sumati Ram-Mohan,\u00a0Timothy A. Norman,\u00a0Ramaswamy Krishnan,\u00a0and\u00a0Alan Fine Team led by Dr. Felicia Chen of the BU Pulmonary Center demonstrates that\u00a0&#8220;Retinoic Acid signaling maintains airway smooth muscle homeostasis by preventing excessive activation of the TGF-\u03b2 pathway. We conclude that tonic RA signaling is [&hellip;]<\/p>\n","protected":false},"author":14042,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3134,3140],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/posts\/11500"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/users\/14042"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/comments?post=11500"}],"version-history":[{"count":2,"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/posts\/11500\/revisions"}],"predecessor-version":[{"id":11504,"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/posts\/11500\/revisions\/11504"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/media?parent=11500"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/categories?post=11500"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/tags?post=11500"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}