{"id":1423,"date":"2009-07-21T13:49:59","date_gmt":"2009-07-21T17:49:59","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/medicine\/?page_id=1423"},"modified":"2012-10-03T15:50:09","modified_gmt":"2012-10-03T19:50:09","slug":"ganley","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/medicine\/education-2-2\/faculty\/ganley\/","title":{"rendered":"The Ganley-Leal Lab"},"content":{"rendered":"

\"ganleyleal_p1000225\"<\/a><\/p>\n

Assistant Professor<\/h2>\n

Education:<\/h4>\n

Ph.D. – University of Connecticut Health Center ASM\/NCID
\nPostdoctoral Fellow – Centers for Disease Control and Prevention
\nPostdoctoral Fellow – BUMC<\/p>\n

General field of research:<\/h4>\n

Immuno-parasitology and chronic inflammation<\/p>\n

Affiliations other than medicine:<\/h4>\n

Evans Center for Interdisciplinary Biomedical Research
\nSection of Infectious Diseases<\/p>\n

Contact information:<\/h4>\n

Office<\/em>
\n650 Albany Street, Room 636
\nPhone: (617) 414-7234<\/p>\n

Lab<\/em>
\n650 Albany Street, Room 630
\nPhone: (617) 414-5217
\nFax: (617) 414-5280<\/p>\n

lisa.ganleyleal@bmc.org<\/a><\/p>\n

Other research websites:<\/h4>\n

www.kemri.org<\/a><\/p>\n

Research group information<\/h4>\n

YanMei Liang, Laboratory Manager, Research Associate
\nQyana Griffith, M.D.\/Ph.D. student
\nJeremy Hetzel, Clinical Coordinator
\nAnsu Mammen Norohna, Gastroenterology Fellow
\nFrancis Farraye, M.D. Collaborator
\nMarie McDonnell, M.D. Collaborator<\/p>\n

Keywords:<\/h4>\n

Schistosomiasis; Global Health; B cells; Chronic Inflammatory Disease; Inflammatory Bowel Disease<\/p>\n

Summary of research interest:<\/h4>\n

Human schistosomiasis, caused by parasitic trematodes, currently affects over 207 million people. A poor understanding of the mechanisms involved in protective immunity has hindered vaccine development. High serum concentrations of parasite-specific IgE are correlated with resistance to schistosomiasis, however, the function(s) of IgE remain elusive. Although B cells are the producers of IgE, remarkably little is known about human B cell function in schistosomiasis. We recently reported that CD23 expression, the low affinity IgE receptor, on B cells is correlated with the development of resistance to schistosome infection in male, occupationally-exposed adult Kenyans. Cross-linking of CD23-bound IgE by antigen induces cellular activation and increased IgE production. However, the role of CD23 in human immunity is exceedingly complex and is virtually unstudied in human schistosomiasis. Our lab focuses on understanding the role of CD23-bound IgE in generating protective immunity as well as the host-parasite interactions between CD23 and schistosomes.<\/p>\n

Our second focus is to understand how Toll-like receptors mediate or regulate inherent inflammatory responses by B cells in chronic inflammatory diseases, including inflammatory bowel disease, type 2 diabetes, and schistosomiasis. This work involves collaboration with several clinicians on campus including Dr. Frank Farraye in Gastroenterology and Dr. Marie McDonnell in Endocrinology.<\/p>\n\n\n\n
\"ganleyleal_kenya-2008-053\"<\/a>\"ganleyleal_p1000230\"<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Recent publications:<\/h4>\n

Mwinzi, P., Ganley-Leal, L.M., Black, C., Secor, W.E., Karanja, D., and Colley, D. 2009. Circulating CD23+ B cell subset correlates with development of resistant to Schistosoma mansoni reinfection in occupationally exposed adults who have undergone multiple treatments. Journal of Infectious Diseases, 199. [PMCID: PMC2636678]<\/p>\n

Shin, H, Zhang, Y, Jagannathan, M, Hasturk, H, Kantarci, A, Liu, H, Van Dyke, TE, Ganley-Leal, LM, and Nikolajczyk, BS. 2009. B cells from periodontal disease patients express surface Toll-like Receptor 4 Journal of Leukocyte Biology, 85(4):648-655. [PMID: 19118102].<\/p>\n

Liang, Y, Ganley-Leal, L. 2009. Technical Note: A simple method for measuring human cell-bound IgE levels in whole blood. Journal of Immunological Methods, 343(2):134-139.<\/p>\n

Ansu Mammen Noronha, YanMei Liang, Jeremy Hetzel, Hatice Hasturk, Alpdogan Kantarci, Arthur Stucchi, Yue Zhang, Barbara S. Nikolajczyk, Francis A. Farraye, and Lisa M. Ganley-Leal. Hyper-activated B cells in human inflammatory bowel disease (In press: Journal of Leukocyte Biology)<\/p>\n

Technologies available for sharing upon request:<\/h4>\n

Flow Cytometry; Phospho-flow; Parasitology; Immuno-epidemiology<\/p>\n","protected":false},"excerpt":{"rendered":"

Assistant Professor Education: Ph.D. – University of Connecticut Health Center ASM\/NCID Postdoctoral Fellow – Centers for Disease Control and Prevention Postdoctoral Fellow – BUMC General field of research: Immuno-parasitology and chronic inflammation Affiliations other than medicine: Evans Center for Interdisciplinary Biomedical Research Section of Infectious Diseases Contact information: Office 650 Albany Street, Room 636 Phone: […]<\/p>\n","protected":false},"author":1750,"featured_media":0,"parent":8,"menu_order":13,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/pages\/1423"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/users\/1750"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/comments?post=1423"}],"version-history":[{"count":5,"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/pages\/1423\/revisions"}],"predecessor-version":[{"id":6846,"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/pages\/1423\/revisions\/6846"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/pages\/8"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/media?parent=1423"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}