{"id":1146,"date":"2009-07-14T19:18:45","date_gmt":"2009-07-14T23:18:45","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/medicine\/1146\/"},"modified":"2022-09-30T15:39:59","modified_gmt":"2022-09-30T19:39:59","slug":"zhong","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/medicine\/education-2-2\/faculty\/zhong\/","title":{"rendered":"Zhong Lab"},"content":{"rendered":"

Xuemei Zhong, PhD
\nAssistant Professor\"zhong_lab-pi\"<\/a>
\n<\/strong><\/h2>\n

<\/h2>\n

Education:<\/h4>\n

PhD, Boston University Chobanian & Avedisian School of Medicine <\/span><\/p>\n

General field of research:<\/h4>\n

Immunology<\/span> <\/span><\/p>\n

Affiliations other than medicine:<\/h4>\n

Evans Center for Interdisciplinary Biomedical Research
\nDepartment of Medicine, Hematology Oncology Section, Boston University Chobanian & Avedisian School of Medicine, Boston Medical Center<\/span><\/p>\n

Contact information:<\/h4>\n

Office<\/em>
\nRm. 437A, EBRC, 650 Albany St., Boston, MA 02118<\/span>
\nPhone: (617)-638 7028<\/p>\n

Lab<\/em>
\nRm. 430, EBRC, 650 Albany St., Boston, MA 02118 <\/span>
\nPhone:\u00a0(617)-638 7535\/7029 <\/span>
\nFax: (617)-638 7140<\/p>\n

xuemei.zhong@bmc.org<\/a><\/span> <\/span><\/p>\n

Other research websites:<\/h4>\n

http:\/\/www.bumc.bu.edu\/hematology\/research-activities\/xuemei-zhong-phd-2\/<\/span><\/a> <\/span><\/p>\n

Research group information<\/h4>\n

<\/p>\n

Chunyan Bai, Research Assistant, <\/span>ChuYan.Bai@bmc.org<\/a><\/span> <\/span><\/p>\n

John P. Lovell, Summer student, <\/span>jlovell@bu.edu<\/a><\/span><\/p>\n

Lynsie Ranker, Summer student, <\/span>ranker@bc.edu<\/a><\/span><\/p>\n

Do Quyen T. Pham, Lab Technical Assistant, quyenp83@yahoo.com<\/a><\/span><\/p>\n

<\/p>\n

Keywords:<\/h4>\n

<\/p>\n

B1 B cell; Regulatory T cells; Regulatory B cells; inflammation; Autoimmune diseases; Cardiovascular diseases<\/p>\n

Summary of research interest:<\/h4>\n

<\/p>\n

Our lab is interested in studying B cells mediated immune regulation in autoimmune diseases and cardiovascular diseases. We are particularly interested in a sub-population of B lymphocytes called B1 B cells. Our preliminary study revealed many faces of B1 B cells in health and diseases. On one hand B1 B cells are critical for immune defense and immune regulation through interaction with other immune cells and producing natural antibodies. On the other hand, B1 B cells are potential “troublemakers” in autoimmune diseases because of their auto-reactivity. A better understanding of the balance between the immune-regulation and pathogenicity of B1 B cells are of significant importance in studying inflammatory autoimmune diseases and cardiovascular diseases.<\/span> <\/span><\/p>\n

<\/p>\n

\"zhong_lab-personnel\"<\/a><\/h4>\n

\"zhong_lab-science\"<\/a><\/h4>\n

Recent publications:<\/h4>\n

<\/p>\n

Zhong, X., T. J. Schneider, et al. (2001). An alternatively spliced long form of Fas apoptosis inhibitory molecule (FAIM) with tissue-specific expression in the brain. Mol Immunol 38: 65-72.<\/span> <\/span><\/p>\n

Zhong, X.,, T. Mizuno, and T. L. Rothstein. (2003). Fas-induced apoptosis in B cells. Apoptosis 8:451.<\/span> <\/span><\/p>\n

Zhong, X., C. Bai, W. Gao, T. B. Strom, and T. L. Rothstein. (2004). Featured Article of the Month: Suppression of expression and function of negative immune regulator PD-1 by certain pattern recognition and cytokine receptor signals associated with immune system danger. Int Immunol 16:1181.<\/span> <\/span><\/p>\n

Barrington, R. A., X. Zhong, M. Zhang, H. Jonsson, N. Holodick, A. Cherukuri, S. K. Pierce, T. L. Rothstein, and M. C. Carroll. (2005). CD21\/CD19 coreceptor signaling promotes B cell survival during primary immune responses. J Immunol 175:2859.<\/span> <\/span><\/p>\n

Zhong, X., J. R. Tumang, W. Gao, C. Bai, and T. L. Rothstein. (2007). PD-L2 expression extends beyond dendritic cells\/macrophages to B1 cells enriched for V(H)11\/V(H)12 and phosphatidylcholine binding. Eur J Immunol 37:2405-2410.<\/span> <\/span><\/p>\n

Zhong, X., W. Gao, N. Degauque, C. Bai, Y. Lu, J. Kenny, M. Oukka, T. B. Strom, and T. L. Rothstein. (2007). Reciprocal generation of Th1\/Th17 and T(reg) cells by B1 and B2 B cells. Eur J Immunol 37:2400-2404.<\/span> <\/span><\/p>\n

Repetny, K., X. Zhong, N. Holodick, T. Rothstein, U. Hansen. (2009). Binding of LBP-1a to specific immunoglobulin switch regions in vivo correlates with specific repression of class switch recombination. Eur J Immunol 39(5):1387-94<\/span> <\/span><\/p>\n

Ding, H., L. Wang, X. Wu, J. Yan, Y. He, B. Ni, W. Gao, X. Zhong. (2009). Blockade of B Cell-Activating Factor Suppresses Lupus-like Syndrome in Autoimmune BXSB Mice. J Cell Mol Med (in press).<\/span> <\/span><\/p>\n

<\/p>\n

Technologies available for sharing upon request:<\/h4>\n

<\/p>\n

Flow Cytometry; Lymphocytes isolation, activation,cell proliferation assay; ELISA; ANA; IHC; Animal model analysis; Retroviral transfection; Bone Marrow Adoptive Transfer<\/span><\/p>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Xuemei Zhong, PhD Assistant Professor Education: PhD, Boston University Chobanian & Avedisian School of Medicine General field of research: Immunology Affiliations other than medicine: Evans Center for Interdisciplinary Biomedical Research Department of Medicine, Hematology Oncology Section, Boston University Chobanian & Avedisian School of Medicine, Boston Medical Center Contact information: Office Rm. 437A, EBRC, 650 Albany […]<\/p>\n","protected":false},"author":1250,"featured_media":0,"parent":8,"menu_order":12,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/pages\/1146"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/users\/1250"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/comments?post=1146"}],"version-history":[{"count":13,"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/pages\/1146\/revisions"}],"predecessor-version":[{"id":19157,"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/pages\/1146\/revisions\/19157"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/pages\/8"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/media?parent=1146"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}