{"id":1003,"date":"2009-07-07T11:38:41","date_gmt":"2009-07-07T15:38:41","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/medicine\/?page_id=1003"},"modified":"2010-05-19T12:09:40","modified_gmt":"2010-05-19T16:09:40","slug":"leukemialymphomalab","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/medicine\/education-2-2\/faculty\/leukemialymphomalab\/","title":{"rendered":"Leukemia and Lymphoma Laboratory"},"content":{"rendered":"

Gerald V. Denis, Ph.D.
\nAssociate Professor<\/h2>\n

Education:<\/h4>\n

Ph.D., University of California, Berkeley
\nPostdoc, University of Massachusetts Medical Center<\/p>\n

General field of research:<\/h4>\n

Cancer<\/p>\n

Affiliations other than medicine:<\/h4>\n

Evans Center for Interdisciplinary Biomedical Research
\nDepartment of Pharmacology
\nHematology\/Oncology Section
\nProgram in Molecular Medicine
\nObesity and Diabetes
\nBoston Obesity Nutrition Research Center
\nFlow Cytometry Core Facility<\/p>\n

Contact information:<\/h4>\n

Office<\/em>
\nConte Building, K520
\nPhone: 617-414-1371<\/p>\n

Lab<\/em>
\nPhone: 617-414-1372
\nFax: 617-638-5673<\/p>\n

gdenis@bu.edu<\/a><\/p>\n

Research group information<\/h4>\n

Fangnian Wang, postdoc<\/p>\n

Wanda Blanton, Immunology Training Program fellow<\/p>\n

Anna Belkina, graduate student<\/p>\n

Hongsheng Liu, research associate<\/p>\n

Other research websites:<\/h4>\n

http:\/\/www.bumc.bu.edu\/immunology\/ <\/a><\/p>\n

http:\/\/www.bumc.bu.edu\/hematology\/hematology-training-grant\/<\/a><\/p>\n

http:\/\/www.bumc.bu.edu\/gpmm\/<\/a><\/p>\n

Keywords:<\/h4>\n

Cancer, stem cells, cancer therapeutics, insulin resistance, obesity, chromatin<\/p>\n

Summary of research interest:<\/h4>\n

The overall goal of my lab is to understand the fundamental mechanisms of transcriptional control of growth and development, and particularly, how chromatin-based disruptions of the eukaryotic cell cycle can lead to malignancy. We focus on the functions of the bromodomain protein Brd2. Results to date have broad significance for our understanding of adaptive immunity, B cell proliferation and non-Hodgkin\u2019s lymphoma (NHL). New results with Brd2 knockdown models have important implications for obesity and insulin resistance.<\/p>\n\n\n\n\n
\"leukemialab_brdu\"<\/a><\/td>\n\"leukemialab_machine\"<\/a><\/td>\n<\/tr>\n
\"leukemialab_sidepop\"<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Recent publications:<\/h4>\n

Greenwald et al (2004) E-mu-BRD2 transgenic mice develop B cell lymphoma and leukemia. Blood 103: 1475\u20131484. PMID: 14563639<\/p>\n

Sinha et al (2005) Bromodomain analysis of Brd2-dependent transcriptional activation of cyclin A. Biochem. J. 387: 257\u2013269. PMID: 15548137<\/p>\n

Denis et al (2006) Identification of transcription complexes that contain the double bromodomain protein Brd2 and chromatin remodeling machines. J. Proteome Res. 5: 502\u2013511. PMID: 16512664<\/p>\n

You et al (2006) The Kaposi\u2019s Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes. J. Virol. 80: 8909\u20138919. PMID: 16940503<\/p>\n

Lenburg et al (2007) Tumor-specific and proliferation-specific gene expression typifies murine transgenic B cell lymphomagenesis. J. Biol. Chem. 282: 4803\u20134811. PMID: 17166848<\/p>\n

Longe et al (2009) Telomere homolog oligonucleotides induce apoptosis in malignant but not in normal lymphoid cells: Mechanism and therapeutic potential. Int. J. Cancer. 124:473\u2013482. PMID: 19003960<\/p>\n

Romesser et al (2009) Development of a malignancy-associated proteomic signature for diffuse large B cell lymphoma. Am. J. Pathol. in press.<\/p>\n

Technologies available for sharing upon request:<\/h4>\n

Retroviral injections and lentivirus production<\/p>\n","protected":false},"excerpt":{"rendered":"

Gerald V. Denis, Ph.D. Associate Professor Education: Ph.D., University of California, Berkeley Postdoc, University of Massachusetts Medical Center General field of research: Cancer Affiliations other than medicine: Evans Center for Interdisciplinary Biomedical Research Department of Pharmacology Hematology\/Oncology Section Program in Molecular Medicine Obesity and Diabetes Boston Obesity Nutrition Research Center Flow Cytometry Core Facility Contact […]<\/p>\n","protected":false},"author":1250,"featured_media":0,"parent":8,"menu_order":17,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/pages\/1003"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/users\/1250"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/comments?post=1003"}],"version-history":[{"count":10,"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/pages\/1003\/revisions"}],"predecessor-version":[{"id":3768,"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/pages\/1003\/revisions\/3768"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/pages\/8"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/medicine\/wp-json\/wp\/v2\/media?parent=1003"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}