Jason Randall Rock PhD

Associate Professor, Pulmonary, Allergy, Sleep & Critical Care Medicine

Faculty, National Emerging Infectious Disease Lab

670 Albany St | (617) 358-0798
Jason Rock
Sections

Pulmonary, Allergy, Sleep & Critical Care Medicine

Centers

Center for Regenerative Medicine

Pulmonary Center

Evans Center for Interdisciplinary Biomedical Research

Biography

Jason Rock, PhD, is an Associate Professor of Medicine at the Boston University School of Medicine. The Rock Lab int he Center for Regenerative Medicine studies how the many different cell types of our lungs are generated during development and how they respond to normal wear and tear, acute injury and disease. The underlying hypothesis is that aberrant (stem) cell behaviors explain many features of lung diseases such as chronic obstructive pulmonary disease, cystic fibrosis, asthma, and pulmonary fibrosis. We use in vivo and in vitro models to identify and test the progenitor capacity of putative stem cell populations and the molecular mechanisms and environmental influences (i.e., niches) that regulate their proliferation and differentiation. Our ultimate goal is to identify genetic, molecular and cellular therapies for the treatment of lung disease.

Other Positions

Education

Molecular and Medical Genetics, PhD, University of Florida College of Medicine, 2008

Biological Sciences, BS, Florida State University - Tallahassee, 2002

Publications

Published on 9/15/2021

Hernandez-Clavijo A, Sarno N, Gonzalez-Velandia KY, Degen R, Fleck D, Rock JR, Spehr M, Menini A, Pifferi S. TMEM16A and TMEM16B Modulate Pheromone-Evoked Action Potential Firing in Mouse Vomeronasal Sensory Neurons. eNeuro. 2021 Sep-Oct; 8(5). PMID: 34433575.

Published on 12/29/2020

Engler AE, Ysasi AB, Pihl RMF, Villacorta-Martin C, Heston HM, Richardson HMK, Thapa BR, Moniz NR, Belkina AC, Mazzilli SA, Rock JR. Airway-Associated Macrophages in Homeostasis and Repair. Cell Rep. 2020 12 29; 33(13):108553. PMID: 33378665.

Published on 12/22/2020

Yeung AK, Villacorta-Martin C, Hon S, Rock JR, Murphy GJ. Lung megakaryocytes display distinct transcriptional and phenotypic properties. Blood Adv. 2020 12 22; 4(24):6204-6217. PMID: 33351116.

Published on 4/2/2020

Basil MC, Katzen J, Engler AE, Guo M, Herriges MJ, Kathiriya JJ, Windmueller R, Ysasi AB, Zacharias WJ, Chapman HA, Kotton DN, Rock JR, Snoeck HW, Vunjak-Novakovic G, Whitsett JA, Morrisey EE. The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future. Cell Stem Cell. 2020 04 02; 26(4):482-502. PMID: 32243808.

Published on 10/1/2019

Engler AE, Mostoslavsky G, Miller L, Rock JR. Isolation, Maintenance and Differentiation of Primary Tracheal Basal Cells from Adult Rhesus Macaque. Methods Protoc. 2019 Oct 01; 2(4). PMID: 31581513.

Published on 5/2/2019

Henriques T, Agostinelli E, Hernandez-Clavijo A, Maurya DK, Rock JR, Harfe BD, Menini A, Pifferi S. TMEM16A calcium-activated chloride currents in supporting cells of the mouse olfactory epithelium. J Gen Physiol. 2019 07 01; 151(7):954-966. PMID: 31048412.

Published on 3/28/2019

Hwang SJ, Pardo DM, Zheng H, Bayguinov Y, Blair PJ, Fortune-Grant R, Cook RS, Hennig GW, Shonnard MC, Grainger N, Peri LE, Verma SD, Rock J, Sanders KM, Ward SM. Differential sensitivity of gastric and small intestinal muscles to inducible knockdown of anoctamin 1 and the effects on gastrointestinal motility. J Physiol. 2019 05; 597(9):2337-2360. PMID: 30843201.

Published on 3/12/2019

Zawieja SD, Castorena JA, Gui P, Li M, Bulley SA, Jaggar JH, Rock JR, Davis MJ. Ano1 mediates pressure-sensitive contraction frequency changes in mouse lymphatic collecting vessels. J Gen Physiol. 2019 04 01; 151(4):532-554. PMID: 30862712.

Published on 5/23/2018

Nguyen QH, Pervolarakis N, Blake K, Ma D, Davis RT, James N, Phung AT, Willey E, Kumar R, Jabart E, Driver I, Rock J, Goga A, Khan SA, Lawson DA, Werb Z, Kessenbrock K. Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity. Nat Commun. 2018 05 23; 9(1):2028. PMID: 29795293.

Published on 3/23/2018

Sung TS, Hwang SJ, Koh SD, Bayguinov Y, Peri LE, Blair PJ, Webb TI, Pardo DM, Rock JR, Sanders KM, Ward SM. The cells and conductance mediating cholinergic neurotransmission in the murine proximal stomach. J Physiol. 2018 05 01; 596(9):1549-1574. PMID: 29430647.

View full list of 58 publications.