{"id":6,"date":"2007-09-18T16:07:27","date_gmt":"2007-09-18T20:07:27","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/leukemia-lymphoma-laboratory\/biographical-information\/"},"modified":"2013-12-19T14:02:27","modified_gmt":"2013-12-19T19:02:27","slug":"biographical-information","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/leukemia-lymphoma-laboratory\/biographical-information\/","title":{"rendered":"Biographical information"},"content":{"rendered":"

\u00a0<\/strong><\/h3>\n

\"\"GERALD V. DENIS, Ph.D.<\/strong><\/p>\n

Associate Professor<\/p>\n

Program in Molecular Medicine and Immunology Training Program<\/p>\n

Section of Hematology\/Oncology, Departments of Pharmacology and Medicine<\/p>\n

Education<\/h4>\n

Harvard College (A.B.)
\nUniversity of Tokyo (M.Sc.)
\nUniversity of California, Berkeley (Ph.D.)<\/p>\n

Positions<\/h4>\n

1979\u201381\u00a0 \u00a0 Research assistant, Physics Department, Harvard University. High Energy Physics Laboratory, Cambridge, MA <\/i><\/p>\n

1981\u201383 \u00a0\u00a0 Research assistant, Biochemistry Department, Boston University School of Medicine (BUSM)<\/i><\/p>\n

1983\u201385 \u00a0\u00a0 Research assistant, University of Tokyo, Faculty of Pharmaceutical Sciences, Tokyo, Japan <\/i><\/p>\n

1985\u201390 \u00a0\u00a0 Research assistant, Molecular and Cellular Biology Department, University of California, Berkeley<\/i><\/p>\n

1991\u201396 \u00a0\u00a0 Fellow, Howard Hughes Medical Institute, University of Massachusetts Medical Center, Worcester<\/i><\/p>\n

1997\u201300 \u00a0\u00a0 Instructor in Medicine, Cancer Research Center, BUSM<\/i><\/p>\n

2000\u201310\u00a0\u00a0\u00a0 Assistant Professor of Medicine, BUSM<\/i><\/p>\n

2003\u201310\u00a0\u00a0\u00a0 Assistant Professor of Pharmacology, BUSM<\/p>\n

2003\u2013 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Member and Instructor, Graduate Program in Molecular Medicine, BUSM<\/p>\n

2003\u2013 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Hematology Training Program-affiliated faculty member, \u201cResearch Training in Blood Diseases and Resources\u201d, T32 HL007501, BUSM<\/p>\n

2006\u201311\u00a0\u00a0\u00a0 Scientific co-Director, Flow Cytometry Core Facility, BUSM<\/p>\n

2012\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Director, Flow Cytometry Core Facility, BUSM<\/p>\n

2007\u2013 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Immunology Training Program-affiliated faculty member, \u201cResearch Program in Immunology\u201d, T32 AI007309, BUSM<\/p>\n

2008\u2013 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Boston Nutrition Obesity Research Center-affiliated faculty member P30 DK046200, BUSM<\/p>\n

2010\u2013 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Associate Professor of Medicine and Pharmacology<\/p>\n

Community Outreach<\/b><\/p>\n

2006 \u2013 12 \u00a0 \u00a0Boston Medical Reserve Corps (Disaster Preparedness, Mass Casualty Exercises, Influenza Inoculation Clinics)<\/p>\n

2009 \u2013 10 \u00a0 \u00a0Boston Marathon, Medical Tent A (Emergency and Triage)<\/p>\n

2006 \u2013 09 \u00a0 \u00a0American Cancer Society Speakers Bureau, US Northeast Region<\/p>\n

2008 \u2013 09 \u00a0 \u00a0American Cancer Society Relay for Life<\/p>\n

Honors<\/h4>\n

1983, Tokyo Biochemical Society Scholarship
\n1984, Yoneyama Rotary Foundation Fellowship, Tokyo
\n1997, NIH FIRST award
\n1997, Aid for Cancer Research Award
\n2004, American Cancer Society Research Scholar Award
\n2005, Jiler \u2013 American Cancer Society Professors Meeting, competitive abstract winner\/participant<\/p>\n

Professional Memberships and Experience<\/span><\/b><\/p>\n

2000\u2013 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 American Society of Hematology (elected)<\/p>\n

2006\u2013 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 American Association for Cancer Research<\/p>\n

2009\u2013 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 The Obesity Society<\/p>\n

2011\u201312 \u00a0\u00a0 The Obesity Society Basic Science Section Chair<\/p>\n

2012\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 American Association of Immunologists<\/p>\n

2012\u201313 \u00a0\u00a0 Obesity Week 2013 Board of Managers<\/p>\n

2013 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Elected Fellow of The Obesity Society<\/p>\n

2013 \u2013 14 \u00a0 Vice-Chair, Obesity and Cancer Section, The Obesity Society<\/p>\n

2014 \u2013 15 \u00a0 Chair-Elect, Obesity and Cancer Section, The Obesity Society<\/p>\n

Community Boards<\/b><\/p>\n

2013 \u2013 \u00a0 \u00a0 \u00a0 \u00a0 South End Community Health Center, Boston, MA. Finance Committee.\u00a0<\/i>With special emphasis on obesity and its metabolic complications in inner city populations. Full Board member<\/i> November 2013<\/p>\n

Peer review activities<\/span><\/b><\/p>\n

1998\u2013 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Reviewer ad hoc<\/i>: Diabetes<\/span>, Endocrinology<\/span>, J. Clin. Endocrinol. Metab.<\/span>; Biochim. Biophys. Acta, Blood, Cell. Physiol. Biochem., Cancer Res., Clin. Cancer Res., EMBO J., Epigenetics, FASEB J., Gene, Genomics, Haematologica, Int. J. Cancer, J. Immunol., Mol. Cancer Therap., Mol. Cell. Biochem., Mol. Cell. Biol., Open Leukemia J, PLoS One.<\/p>\n

2000\u201312\u00a0\u00a0\u00a0 Managing editorships: Journal of the Pancreas, Frontiers in Bioscience; Editorial boards: Frontiers in Bioscience<\/p>\n

2004\u201308\u00a0\u00a0\u00a0 NIH Peer Review Committee: Cancer Prevention Research and Epidemiology Study Section (NCI). ad hoc<\/b><\/i> 2011 \u2013 2013 inclusive<\/b><\/p>\n

2005 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 NIH Peer Review Committee: Initiative on Transdisciplinary Research on Energetics and Cancer (TREC), (NCI)<\/p>\n

2005\u201312 \u00a0\u00a0 Peer Review Committee: Leukemia, Immunology and Blood Cell Development, American Cancer Society (Regular Member, term expired 2010; ad hoc<\/i> 2011 \u2013 2012)<\/p>\n

2005\u2013 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Peer Review of applications to Alpha Omega Alpha medical honor society<\/p>\n

2005\u2013 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Peer Review Committee: State of Florida Department of Health, James and Esther King Biomedical Research Program for cancer research grants<\/p>\n

2009\u2013 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Reviewer ad hoc<\/i>, National Science Foundation, Division of Molecular and Cellular Biosciences<\/p>\n

2012\u2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Institute of Medicine Advisory Panel on nutrition, diabetes and obesity (Dir: Dr Barbara Hansen)<\/p>\n

2013\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 NIH Peer Review Committee: NCI Provocative Questions (PQB), (NCI). Ad hoc<\/i><\/p>\n

Invited scientific presentations<\/span><\/b><\/p>\n

(2011). Bromodomain co-regulators in obesity, cancer and inflammation. Symposium on NF-\u03baB, cancer, obesity and inflammation. Cincinnati Cancer Symposium Series, Cincinnati<\/p>\n

(2012). Mechanisms that link obesity and cancer. Society for Preventive Medicine. Annual Meeting, New Orleans, LA<\/p>\n

(2012). Cancer and energy balance. The Obesity Society, San Antonio, TX<\/p>\n

(2012). Obesity and cancer risk. 20th<\/sup> United Europoean Gastroenterology Week, Amsterdam<\/p>\n

(2013). Unresolved, chronic inflammation as a critical link between insulin-resistant obesity and cancer. American Association of Immunologists, Honolulu, HI<\/p>\n

(2013). Chronic inflammation as a critical link between insulin-resistant obesity and certain cancers. Forsyth Institute, Cambridge, MA<\/p>\n

(2014). Chair. Unresolved, chronic inflammation as a mediator of diverse disease risks in insulin-resistant obesity. American Association of Immunologists, Pittsburgh, PA<\/p>\n

Recent Publications<\/h4>\n

Belkina AC, Nikolajczyk BS, Denis GV. (2013). BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair macrophage inflammatory responses. J. Immunol<\/i>. 190: 3670\u20133678. PMCID: PMC3608815<\/p>\n

DeFuria J, Belkina AC, Jagannathan-Bogdan M, Snyder-Cappione J, Carr JD, Nersesova Y, Markham D, Strissel KJ, Watkins A, Allen J, Bouchard J, Toraldo G, Jasuja R, Obin MS, McDonnell ME, Apovian CM, <\/sup>Denis GV, Nikolajczyk BS. (2013). B cells regulate the pro-inflammatory T cell balance in obesity and metabolic disease. Proc. Natl. Acad. Sci. USA<\/i>.110:5133\u20135188. PMCID: PMC3612635<\/p>\n

Belkina AC, Denis GV (2012). BET domain co-regulators in obesity, inflammation and cancer. Nature Rev. Cancer<\/i>. 12: 465\u2013477. PMCID \u2013 In process.<\/p>\n

Nikolajczyk BS, Jagannathan-Bogdan M, Denis GV. (2012). The outliers become a stampede as immunometabolism reaches a tipping point. Immunol. Rev. <\/i>249: 253\u2013275. PMID: 22889227, PMCID PMC3419483<\/p>\n

Denis GV. (2010). Bromodomain coactivators in cancer, obesity, type 2 diabetes and inflammation. Discov Med<\/i>.<\/i> 10:489\u2013499. PMCID: PMC3025494<\/p>\n

Belkina AC, Denis GV. (2010). Obesity genes and insulin resistance. Curr Opin Endocrinol Diabetes Obes<\/i>. 17:472\u2013477. PMID: 20585247 PMCID: PMCID: PMC307938<\/p>\n

Denis GV, Nikolajczyk BS, Schnitzler GR. (2010). An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis. FEBS Lett<\/i>. <\/i>584:3260\u20133268. PMCID: PMC2914217<\/p>\n

Wang F, Liu H, Blanton WP, Belkina A, Lebrasseur NK, Denis GV. (2009). Brd2 <\/i>disruption in mice causes severe obesity without type 2 diabetes. Biochem J.<\/i> 425:71\u201383. PMCID: PMC2819394<\/p>\n

Important recent reviews:<\/strong><\/p>\n

Denis GV, Huffman D, LeBrasseur NK (2013). The biology of aging: Role in cancer, metabolic dysfunction and health disparities. In Energy Balance and Cancer<\/i>, Volume 9: <\/i>Impact of Energy Balance on Cancer Disparities. DJ Bowen, GV Denis, NA Berger, Eds.; Springer, New York. Expected November 2013.<\/p>\n

Denis GV, Hamilton JA (2013). Healthy obese persons: How can they be identified and do metabolic profiles stratify risk?\u00a0Curr. Opin. Endocrinol. Diabetes Obes<\/i>. 20:369\u2013376. PMID 23974763, PMCID \u2013 In process<\/p>\n

Denis GV, Bowen DJ. (2013). Uncoupling obesity from cancer: Bromodomain co-regulators that control networks of inflammatory genes. In Energy Balance and Cancer<\/i>, Chapter 3, Volume 8: Obesity, Inflammation and Cancer. AJ Dannenberg, NA Berger, Eds.; Springer, New York. pp. 61\u201382.<\/p>\n

Wang F, Deeney JT, Denis GV. (2013). Brd2<\/i> gene disruption causes \u2018metabolically healthy\u2019 obesity: Epigenetic and chromatin-based mechanisms that uncouple obesity from Type 2 diabetes. In Vitamins and Hormones <\/i>91: 49\u201375. G Litwack, Ed.; Elsevier Academic Press, Amsterdam. PMID: 23374712<\/p>\n

Additional publications of interest:<\/strong><\/p>\n

Ehrlich DJ, McKenna BK, Evans JG, Belkina AC, Denis GV, Sherr DH, Cheung MC. (2011). Parallel imaging microfluidic cytometer. Meth Cell Biol.<\/em> 12: In press.<\/em><\/p>\n

Longe HO, PB Romesser, AM Rankin, DV Faller, MS Eller, BA Gilchrest and <\/strong>GV Denis (2009). Telomere homolog oligonucleotides induce apoptosis in malignant but not in normal lymphoid cells: Mechanism and therapeutic potential. Int. J. Cancer.<\/em> 124: 473\u2013482.<\/p>\n

Romesser PB, Perlman DH, Faller DV, Costello CE, McComb ME, Denis GV. (2009). Development of a malignancy-associated proteomic signature for diffuse large B cell lymphoma. Am J Pathol.<\/em> 175:25\u201335.<\/p>\n

Lenburg ME, Sinha A, Faller DV, Denis GV. (2007). Tumor-specific and proliferation-specific gene expression typifies murine transgenic B cell lymphomagenesis. J Biol Chem.<\/em> 282:4803\u20134811.<\/p>\n

Denis GV, McComb ME, Faller DV, Sinha A, Romesser PB, Costello CE (2006). Identification of transcription complexes that contain the double bromodomain protein Brd2 and chromatin remodeling machines. J Proteome Res<\/em>. 5:502\u2013511<\/p>\n

You J, Srinivasan V, Denis GV, Harrington WJ Jr, Ballestas ME, Kaye KM, Howley PM. (2006). Kaposi’s Sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes. J Virol.<\/em> 80:8909\u20138919.<\/p>\n

Sinha A, Faller DV, Denis GV. (2005). Bromodomain analysis of Brd2-dependent transcriptional activation of cyclin A<\/em>. Biochem J. <\/em>387:257\u2013269.<\/p>\n

Book Chapters<\/em>
\nDenis, G. V. (2007). Imatinib mesylate (Gleevec) and the emergence of chemotherapeutic drug-resistant mutations. In H. L. Kaufman, S. Wadler and K. H. Antman, Eds., Cancer Drug Discovery and Development; Specific Drugs for Molecular Targeting in Oncology<\/em>, Part IV, Chapter 22. Humana Press; Totowa, NJ. In press.<\/em><\/p>\n

Seminal, early insights into BET protein structure and function:<\/h4>\n

Denis GV. (2001). Bromodomain motifs and “scaffolding”? Frontiers in Bioscience<\/i> 6: D1065-8. PMID: 11532602; PMC3042883<\/p>\n

Denis GV. (2001). Duality in bromodomain-containing protein complexes. Frontiers in Bioscience<\/i> 6: D849-52. PMID: 11487463; PMC3034383<\/p>\n","protected":false},"excerpt":{"rendered":"

\u00a0 GERALD V. DENIS, Ph.D. Associate Professor Program in Molecular Medicine and Immunology Training Program Section of Hematology\/Oncology, Departments of Pharmacology and Medicine Education Harvard College (A.B.) University of Tokyo (M.Sc.) University of California, Berkeley (Ph.D.) Positions 1979\u201381\u00a0 \u00a0 Research assistant, Physics Department, Harvard University. High Energy Physics Laboratory, Cambridge, MA 1981\u201383 \u00a0\u00a0 Research assistant, […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":13,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/leukemia-lymphoma-laboratory\/wp-json\/wp\/v2\/pages\/6"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/leukemia-lymphoma-laboratory\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/leukemia-lymphoma-laboratory\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/leukemia-lymphoma-laboratory\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/leukemia-lymphoma-laboratory\/wp-json\/wp\/v2\/comments?post=6"}],"version-history":[{"count":27,"href":"https:\/\/www.bumc.bu.edu\/leukemia-lymphoma-laboratory\/wp-json\/wp\/v2\/pages\/6\/revisions"}],"predecessor-version":[{"id":203,"href":"https:\/\/www.bumc.bu.edu\/leukemia-lymphoma-laboratory\/wp-json\/wp\/v2\/pages\/6\/revisions\/203"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/leukemia-lymphoma-laboratory\/wp-json\/wp\/v2\/media?parent=6"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}