{"id":3,"date":"2009-07-29T16:35:45","date_gmt":"2009-07-29T20:35:45","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/kottonlab\/home\/"},"modified":"2026-01-30T14:57:56","modified_gmt":"2026-01-30T19:57:56","slug":"home","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/kottonlab\/","title":{"rendered":"The Kotton Lab"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" src=\"\/kottonlab\/files\/2026\/01\/IMG_2062-451x300.jpeg\" alt=\"\" width=\"451\" height=\"300\" class=\"alignnone size-medium wp-image-2915\" srcset=\"https:\/\/www.bumc.bu.edu\/kottonlab\/files\/2026\/01\/IMG_2062-451x300.jpeg 451w, https:\/\/www.bumc.bu.edu\/kottonlab\/files\/2026\/01\/IMG_2062-1024x681.jpeg 1024w, https:\/\/www.bumc.bu.edu\/kottonlab\/files\/2026\/01\/IMG_2062-768x510.jpeg 768w, https:\/\/www.bumc.bu.edu\/kottonlab\/files\/2026\/01\/IMG_2062-1536x1021.jpeg 1536w, https:\/\/www.bumc.bu.edu\/kottonlab\/files\/2026\/01\/IMG_2062-2048x1361.jpeg 2048w\" sizes=\"(max-width: 451px) 100vw, 451px\" \/><\/p>\n<p style=\"text-align: left;\"><strong>The Kott<a href=\"http:\/\/www.bumc.bu.edu\/stemcells\/\"><img loading=\"lazy\" alt=\"crmlogohi\" src=\"\/kottonlab\/files\/2009\/09\/crmlogohi.jpg\" class=\"alignright size-full wp-image-33\" width=\"225\" height=\"120\" \/><\/a>on lab\u2019s goal is advancing our understanding of lung disease and developmental biology with a focus on stem cell biology and gene therapy. We believe that novel treatments for many lung diseases can be realized based on a better understanding of how the lung develops as well as regenerates after lung injury.<a href=\"https:\/\/youtu.be\/VVxW2I8IHM0\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" src=\"\/kottonlab\/files\/2017\/05\/Lab-TV-Darrell-Kotton-2015-539x300.jpeg\" alt=\"Kotton Lab Featured on Lab TV\" class=\"wp-image-1627 alignright\" width=\"256\" height=\"142\" srcset=\"https:\/\/www.bumc.bu.edu\/kottonlab\/files\/2017\/05\/Lab-TV-Darrell-Kotton-2015-539x300.jpeg 539w, https:\/\/www.bumc.bu.edu\/kottonlab\/files\/2017\/05\/Lab-TV-Darrell-Kotton-2015-768x427.jpeg 768w, https:\/\/www.bumc.bu.edu\/kottonlab\/files\/2017\/05\/Lab-TV-Darrell-Kotton-2015-1024x570.jpeg 1024w, https:\/\/www.bumc.bu.edu\/kottonlab\/files\/2017\/05\/Lab-TV-Darrell-Kotton-2015.jpeg 1280w\" sizes=\"(max-width: 256px) 100vw, 256px\" \/><\/a><br \/>\n<\/strong><\/p>\n<p>We are particularly interested in understanding how lung cells decide and remember who they are. To this end, one focus of our group is defining the genomic and epigenomic programs that regulate lung cell fate. A longer term goal is the de novo generation of the full diversity of lung lineages and transplantable 3D lung tissues from pluripotent stem cells. Our Principal Investigator, <a href=\"https:\/\/www.bumc.bu.edu\/kottonlab\/lab-members-2\/\">Dr. Darrell Kotton<\/a>, also serves as the founding Director of the Center for Regenerative Medicine (CReM). <a href=\"http:\/\/www.bu.edu\/dbin\/stemcells\/index.php\" target=\"_blank\" rel=\"noopener noreferrer\">Take a full tour of the CReM<\/a> by clicking on our logo above.<strong><a href=\"http:\/\/www.bu.edu\/research\/magazine\/2012\/dialogues\/opening-the-doors-to-opensource-medicine\/index.shtml\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" src=\"\/kottonlab\/files\/2009\/07\/Opening-doors-to-open-source-medicine-631x300.jpg\" alt=\"Opening doors to open source medicine\" class=\"alignright wp-image-1435\" width=\"345\" height=\"164\" srcset=\"https:\/\/www.bumc.bu.edu\/kottonlab\/files\/2009\/07\/Opening-doors-to-open-source-medicine-631x300.jpg 631w, https:\/\/www.bumc.bu.edu\/kottonlab\/files\/2009\/07\/Opening-doors-to-open-source-medicine-768x365.jpg 768w, https:\/\/www.bumc.bu.edu\/kottonlab\/files\/2009\/07\/Opening-doors-to-open-source-medicine-1024x486.jpg 1024w, https:\/\/www.bumc.bu.edu\/kottonlab\/files\/2009\/07\/Opening-doors-to-open-source-medicine.jpg 1044w\" sizes=\"(max-width: 345px) 100vw, 345px\" \/><\/a><\/strong><\/p>\n<p><strong><em><\/em><\/strong><\/p>\n<p><b>Click on the menu to learn more about our research areas and our team<\/b><\/p>\n<p><strong>Have forty five minutes for an overview of our last deca<\/strong><strong>de? <a href=\"https:\/\/youtu.be\/fQ-ylRUg2ME\" target=\"_blank\" rel=\"noopener noreferrer\">Listen here to Darrell&#8217;s CReM 10 Year Anniversary Grand Rounds 2023 Lecture<\/a><\/strong><\/p>\n<p><strong> <a href=\"https:\/\/www.youtube.com\/embed\/9YP5P6dRD58\" target=\"_blank\" rel=\"noopener noreferrer\">Listen here to Darrell&#8217;s ATS Discovery Series Lecture, &#8220;Lung Regeneration: An Achievable Mission.&#8221;<\/a><\/strong><\/p>\n<p><strong>Open Source Works! Click here to access our:\u00a0<\/strong><strong>\u00a0<a href=\"http:\/\/www.bu.edu\/dbin\/stemcells\/iPSC_bank.php\">iPS Cell Lines<\/a>, <a href=\"https:\/\/www.bumc.bu.edu\/kottonlab\/vectors-and-plasmids\/\">Lentiviral Vectors<\/a>, <a href=\"https:\/\/www.bumc.bu.edu\/kottonlab\/bioinformatics-portal-kotton-lab\/\">Bioinformatics Datasets<\/a>, <a href=\"https:\/\/www.bumc.bu.edu\/kottonlab\/interstitial-lung-disease-ild-induced-pluripotent-stem-cell-ipsc-biorepository\/\" target=\"_blank\" rel=\"noopener noreferrer\">ILD iPSC Biorepository<\/a>, or <a href=\"https:\/\/www.bumc.bu.edu\/kottonlab\/vectors-and-plasmids\/protocols\/\">Detailed Protocols<\/a>\u00a0!<\/strong><\/p>\n<p><strong>or read more about <a href=\"http:\/\/www.bu.edu\/dbin\/stemcells\/open_source_biology.php\">our Open Source Biology Philosophy<\/a>\u00a0or a recent <a href=\"http:\/\/www.bu.edu\/research\/magazine\/2012\/dialogues\/opening-the-doors-to-opensource-medicine\/index.shtml\" target=\"_blank\" rel=\"noopener noreferrer\">interview on Darrell&#8217;s approach to sharing our cells<\/a><\/strong><\/p>\n<p><strong>Want to learn how to give a good talk or run a journal club? <a href=\"https:\/\/www.bumc.bu.edu\/kottonlab\/teaching-materials\/\" target=\"_blank\" rel=\"noopener noreferrer\">Check out our teaching materials!<\/a><\/strong><\/p>\n<p><img loading=\"lazy\" src=\"\/kottonlab\/files\/2020\/02\/IMG_2896-400x300.jpg\" alt=\"\" width=\"400\" height=\"300\" class=\"alignnone size-medium wp-image-2031\" srcset=\"https:\/\/www.bumc.bu.edu\/kottonlab\/files\/2020\/02\/IMG_2896-400x300.jpg 400w, https:\/\/www.bumc.bu.edu\/kottonlab\/files\/2020\/02\/IMG_2896-768x576.jpg 768w, https:\/\/www.bumc.bu.edu\/kottonlab\/files\/2020\/02\/IMG_2896-1024x768.jpg 1024w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/p>\n<p><a href=\"https:\/\/www.bumc.bu.edu\/kottonlab\/photos\/\" target=\"_blank\" rel=\"noopener noreferrer\">More photos of lab life<\/a><\/p>\n<p>See all our latest news on \u00a0twitter: \u00a0<a href=\"https:\/\/twitter.com\/Kottond\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" src=\"https:\/\/img.clipartfest.com\/3ca714319861d6d0f53f9b7b4f5971fc_13-twitter-logo-vector-png-clipart-twitter-logo_518-518.png\" class=\"alignnone\" width=\"38\" height=\"38\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; The Kotton lab\u2019s goal is advancing our understanding of lung disease and developmental biology with a focus on stem cell biology and gene therapy. We believe that novel treatments for many lung diseases can be realized based on a better understanding of how the lung develops as well as regenerates after lung injury. We [&hellip;]<\/p>\n","protected":false},"author":1319,"featured_media":0,"parent":0,"menu_order":14,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/kottonlab\/wp-json\/wp\/v2\/pages\/3"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/kottonlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/kottonlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/kottonlab\/wp-json\/wp\/v2\/users\/1319"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/kottonlab\/wp-json\/wp\/v2\/comments?post=3"}],"version-history":[{"count":51,"href":"https:\/\/www.bumc.bu.edu\/kottonlab\/wp-json\/wp\/v2\/pages\/3\/revisions"}],"predecessor-version":[{"id":2916,"href":"https:\/\/www.bumc.bu.edu\/kottonlab\/wp-json\/wp\/v2\/pages\/3\/revisions\/2916"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/kottonlab\/wp-json\/wp\/v2\/media?parent=3"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}