{"id":2350,"date":"2021-09-30T18:21:27","date_gmt":"2021-09-30T22:21:27","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/kottonlab\/?page_id=2350"},"modified":"2025-05-15T13:46:34","modified_gmt":"2025-05-15T17:46:34","slug":"interstitial-lung-disease-ild-induced-pluripotent-stem-cell-ipsc-biorepository","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/kottonlab\/interstitial-lung-disease-ild-induced-pluripotent-stem-cell-ipsc-biorepository\/","title":{"rendered":"Interstitial Lung Disease (ILD) Induced Pluripotent Stem Cell (iPSC) Biorepository"},"content":{"rendered":"<figure id=\"attachment2155\" aria-describedby=\"caption-attachment2155\" style=\"width: 477px\" class=\"wp-caption alignright\"><img loading=\"lazy\" src=\"\/kottonlab\/files\/2020\/03\/Screen-Shot-2020-03-22-at-4.12.16-PM-467x300.png\" alt=\"\" width=\"467\" height=\"300\" class=\"wp-image-2155 size-medium\" srcset=\"https:\/\/www.bumc.bu.edu\/kottonlab\/files\/2020\/03\/Screen-Shot-2020-03-22-at-4.12.16-PM-467x300.png 467w, https:\/\/www.bumc.bu.edu\/kottonlab\/files\/2020\/03\/Screen-Shot-2020-03-22-at-4.12.16-PM-768x493.png 768w, https:\/\/www.bumc.bu.edu\/kottonlab\/files\/2020\/03\/Screen-Shot-2020-03-22-at-4.12.16-PM.png 975w\" sizes=\"(max-width: 467px) 100vw, 467px\" \/><figcaption id=\"caption-attachment2155\" class=\"wp-caption-text\">See our catalogue to request an iPSC line<\/figcaption><\/figure>\n<p>Welcome to the Interstitial Lung Disease iPSC Biorepository. Through this webpage you can access induced pluripotent stem cell (iPSC) lines generated by reprogramming somatic cells (blood or fibroblasts) procured with informed consent from patients with\u00a0 interstitial lung disease (ILD), pulmonary fibrosis (either idiopathic\/sporadic or familial forms), or their familial controls. The resulting stem cell lines are archived as frozen, shareable vials housed in our Center for Regenerative Medicine at Boston University and Boston Medical Center. Please <a href=\"https:\/\/stemcellbank.bu.edu\/Catalog\/Item\/Home\" target=\"_blank\" rel=\"noopener noreferrer\">access the searchable catalogue of these lines at this link<\/a>, where information on how to request the lines from our iPSC Core facility is also detailed.<\/p>\n<p>When you click on the above link, you will be taken to a searchable catalogue; try typing in the search window the phrase &#8220;interstitial lung disease&#8221;, one of the diagnoses listed below, or type in a gene name relevant to ILD risk (e.g TERT, TERC, RTEL1, ABCA3, SFTPC, NKX2-1, HPS, etc).<\/p>\n<p><strong>Our ILD biorepository includes iPSC lines from patients with the following diagnoses:<\/strong><\/p>\n<ul>\n<li>Idiopathic pulmonary fibrosis<\/li>\n<li>Familial pulmonary fibrosis<\/li>\n<li>Hermansky-Pudlak Syndrome<\/li>\n<li><a href=\"https:\/\/www.bumc.bu.edu\/kottonlab\/childhood-interstitial-lung-diseases-child-induced-pluripotent-stem-cell-ipsc-biorepository\/\" target=\"_blank\" rel=\"noopener noreferrer\">Childhood interstitial lung disease (ChILD)<\/a><\/li>\n<li><a href=\"https:\/\/www.bumc.bu.edu\/kottonlab\/tbx4life-ipsc-biorepository\/\" target=\"_blank\" rel=\"noopener noreferrer\">TBX4 Syndrome<\/a><\/li>\n<li>Scleroderma<\/li>\n<li>Genetic ILD risk alleles: TERT (pending), TERC, RTEL1, ABCA3, SFTPC, NKX2-1, HPS1<\/li>\n<\/ul>\n<figure id=\"attachment1656\" aria-describedby=\"caption-attachment1656\" style=\"width: 389px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" src=\"\/kottonlab\/files\/2017\/05\/mouse-lung-with-bleomycin-injury-379x300.jpg\" alt=\"\" width=\"379\" height=\"300\" class=\"wp-image-1656 size-medium\" srcset=\"https:\/\/www.bumc.bu.edu\/kottonlab\/files\/2017\/05\/mouse-lung-with-bleomycin-injury-379x300.jpg 379w, https:\/\/www.bumc.bu.edu\/kottonlab\/files\/2017\/05\/mouse-lung-with-bleomycin-injury-768x608.jpg 768w, https:\/\/www.bumc.bu.edu\/kottonlab\/files\/2017\/05\/mouse-lung-with-bleomycin-injury-1024x811.jpg 1024w, https:\/\/www.bumc.bu.edu\/kottonlab\/files\/2017\/05\/mouse-lung-with-bleomycin-injury.jpg 1280w\" sizes=\"(max-width: 379px) 100vw, 379px\" \/><figcaption id=\"caption-attachment1656\" class=\"wp-caption-text\">Lung tissue section<\/figcaption><\/figure>\n<p>We thank the NIH\/NHLBI for a U01 consortium grant that made the launch of this bank possible, as well as the volunteers, donors, and patients who donated samples. We are grateful also for prior funds given to the CReM to support cell procurement from the following patient foundations, organizations, and institutes: the HPS Network, the chILD Foundation, the Pulmonary Fibrosis Foundation, and the National Heart Lung and Blood Institute.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Welcome to the Interstitial Lung Disease iPSC Biorepository. Through this webpage you can access induced pluripotent stem cell (iPSC) lines generated by reprogramming somatic cells (blood or fibroblasts) procured with informed consent from patients with\u00a0 interstitial lung disease (ILD), pulmonary fibrosis (either idiopathic\/sporadic or familial forms), or their familial controls. The resulting stem cell lines [&hellip;]<\/p>\n","protected":false},"author":1319,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/kottonlab\/wp-json\/wp\/v2\/pages\/2350"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/kottonlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/kottonlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/kottonlab\/wp-json\/wp\/v2\/users\/1319"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/kottonlab\/wp-json\/wp\/v2\/comments?post=2350"}],"version-history":[{"count":5,"href":"https:\/\/www.bumc.bu.edu\/kottonlab\/wp-json\/wp\/v2\/pages\/2350\/revisions"}],"predecessor-version":[{"id":2852,"href":"https:\/\/www.bumc.bu.edu\/kottonlab\/wp-json\/wp\/v2\/pages\/2350\/revisions\/2852"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/kottonlab\/wp-json\/wp\/v2\/media?parent=2350"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}