{"id":2823,"date":"2017-03-06T12:07:45","date_gmt":"2017-03-06T17:07:45","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/immunology\/?page_id=2823"},"modified":"2017-03-06T12:23:50","modified_gmt":"2017-03-06T17:23:50","slug":"gregory-hall","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/immunology\/trainees\/predoc\/gregory-hall\/","title":{"rendered":"Gregory Hall"},"content":{"rendered":"<h3>PhD C<a href=\"\/immunology\/files\/2017\/03\/GH.jpg\"><img loading=\"lazy\" src=\"\/immunology\/files\/2017\/03\/GH-199x300.jpg\" alt=\"GH\" class=\" wp-image-2824 alignleft\" width=\"139\" height=\"210\" srcset=\"https:\/\/www.bumc.bu.edu\/immunology\/files\/2017\/03\/GH-199x300.jpg 199w, https:\/\/www.bumc.bu.edu\/immunology\/files\/2017\/03\/GH-768x1160.jpg 768w, https:\/\/www.bumc.bu.edu\/immunology\/files\/2017\/03\/GH-678x1024.jpg 678w\" sizes=\"(max-width: 139px) 100vw, 139px\" \/><\/a>andidate in Pathology &amp; Laboratory Medicine<\/h3>\n<p>BS \u2013 Cornell University, 2006<\/p>\n<p>DVM \u2013 The Ohio State University, 2010<\/p>\n<p>3<sup>rd<\/sup> Year Doctoral Student<\/p>\n<p>Stearns-Kurosawa Lab<\/p>\n<p>&nbsp;<\/p>\n<p>The Stearns-Kurosawa Lab studies the pathologic effects of bacterially produced Shiga toxins utilizing various <em>in vivo <\/em>models.\u00a0 Shiga toxin-producing <em>E. coli <\/em>(STEC) are a food-borne pathogen responsible for epidemic outbreaks of diarrhea around the globe.\u00a0\u00a0 Most patients recover from STEC-induced hemorrhagic diarrhea without complication, but 5-15% of infected patients develop a potentially fatal thrombotic microangiopathy known as hemolytic uremic syndrome (HUS).<\/p>\n<p>Our lab is developing a murine model of STEC infection via alteration of the colonic microenvironment to facilitate successful <em>E. coli<\/em> colonization with subsequent Shiga toxin-induced disease. \u00a0\u00a0My project is to optimize and characterize our novel model of STEC infection.\u00a0 In particular, we are focused on the impact of Shiga toxin on the gastrointestinal mucosal immune response, as the toxins are known to induce acute cytokine release from a variety of cell types <em>in vitro<\/em> but little is known about their <em>in vivo<\/em> effects.\u00a0 Delineation of the host immune response to STEC may identify novel therapeutic targets for the prevention of HUS or biomarkers that can differentiate diarrhea-only patients from future HUS patients at the time of presentation.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>PhD Candidate in Pathology &amp; Laboratory Medicine BS \u2013 Cornell University, 2006 DVM \u2013 The Ohio State University, 2010 3rd Year Doctoral Student Stearns-Kurosawa Lab &nbsp; The Stearns-Kurosawa Lab studies the pathologic effects of bacterially produced Shiga toxins utilizing various in vivo models.\u00a0 Shiga toxin-producing E. coli (STEC) are a food-borne pathogen responsible for epidemic [&hellip;]<\/p>\n","protected":false},"author":11149,"featured_media":0,"parent":2457,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/pages\/2823"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/users\/11149"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/comments?post=2823"}],"version-history":[{"count":2,"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/pages\/2823\/revisions"}],"predecessor-version":[{"id":2827,"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/pages\/2823\/revisions\/2827"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/pages\/2457"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/media?parent=2823"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}