{"id":2812,"date":"2017-03-06T11:31:48","date_gmt":"2017-03-06T16:31:48","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/immunology\/?page_id=2812"},"modified":"2017-03-06T12:24:41","modified_gmt":"2017-03-06T17:24:41","slug":"jaileene-hernandez-escalante","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/immunology\/trainees\/predoc\/jaileene-hernandez-escalante\/","title":{"rendered":"Jaileene Hernandez Escalante"},"content":{"rendered":"<h3><a href=\"\/immunology\/files\/2017\/03\/JHE.jpg\"><img loading=\"lazy\" src=\"\/immunology\/files\/2017\/03\/JHE-300x300.jpg\" alt=\"JHE\" class=\"size-medium wp-image-2813 alignleft\" width=\"300\" height=\"300\" srcset=\"https:\/\/www.bumc.bu.edu\/immunology\/files\/2017\/03\/JHE-300x300.jpg 300w, https:\/\/www.bumc.bu.edu\/immunology\/files\/2017\/03\/JHE-150x150.jpg 150w, https:\/\/www.bumc.bu.edu\/immunology\/files\/2017\/03\/JHE.jpg 495w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><strong>PhD in Microbiology<\/strong><\/h3>\n<p>B.S. in Biology, Temple University<\/p>\n<p>T1D is an autoimmune disorder involving the destruction of pancreatic \u03b2 cells by autoreactive T cells leading to a loss of insulin production and control of blood glucose levels. While genetic components to the disease exist, there is evidence that environmental factors may play a role in disease progression. Abnormalities in lipid metabolism often occur in T1D patients and I am interested in how metabolic environmental effects contribute to Type 1 Diabetes (T1D) disease progression. My dissertation research in Dr. Hans Dooms\u2019 lab will be to understand the effect of different chain length fatty acids on phenotype and function of T cells from the non-obese diabetic (NOD) mouse model along with the effects on disease pathogenesis. The T cell metabolic program promptly changes depending on the activation state of cells and influences T cell phenotype. These metabolic programs match T cell function where T helper Th1 and Th2 cells rely on glycolysis to carry out their roles while CD8<sup>+ <\/sup>memory and T regulatory cells depend on fatty acid oxidation and oxidative phosphorylation. We are working to understand how changes in the cell-extrinsic metabolic environment as well as cell-intrinsic defects in metabolic pathways may alter T cell responses and promote autoimmunity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>PhD in Microbiology B.S. in Biology, Temple University T1D is an autoimmune disorder involving the destruction of pancreatic \u03b2 cells by autoreactive T cells leading to a loss of insulin production and control of blood glucose levels. While genetic components to the disease exist, there is evidence that environmental factors may play a role in [&hellip;]<\/p>\n","protected":false},"author":11149,"featured_media":0,"parent":2457,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/pages\/2812"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/users\/11149"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/comments?post=2812"}],"version-history":[{"count":1,"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/pages\/2812\/revisions"}],"predecessor-version":[{"id":2814,"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/pages\/2812\/revisions\/2814"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/pages\/2457"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/media?parent=2812"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}