{"id":2614,"date":"2014-09-12T11:47:39","date_gmt":"2014-09-12T15:47:39","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/immunology\/?page_id=2614"},"modified":"2017-03-06T12:25:09","modified_gmt":"2017-03-06T17:25:09","slug":"francis","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/immunology\/trainees\/predoc\/francis\/","title":{"rendered":"Ian Francis"},"content":{"rendered":"<h3><a title=\"Lee M. Wetzler, MD\" href=\"https:\/\/www.bumc.bu.edu\/immunology\/faculty\/wetzler\/\"><img loading=\"lazy\" src=\"\/immunology\/files\/2014\/09\/IanFrancisWebsitePicture-346x300.jpg\" alt=\"O\" class=\"alignleft wp-image-2615\" width=\"175\" height=\"151\" srcset=\"https:\/\/www.bumc.bu.edu\/immunology\/files\/2014\/09\/IanFrancisWebsitePicture-346x300.jpg 346w, https:\/\/www.bumc.bu.edu\/immunology\/files\/2014\/09\/IanFrancisWebsitePicture-1024x887.jpg 1024w, https:\/\/www.bumc.bu.edu\/immunology\/files\/2014\/09\/IanFrancisWebsitePicture.jpg 1458w\" sizes=\"(max-width: 175px) 100vw, 175px\" \/><\/a>MD\/PhD in Microbiology<\/h3>\n<p>BS, University of Denver<\/p>\n<p><a title=\"Lee M. Wetzler, MD\" href=\"https:\/\/www.bumc.bu.edu\/immunology\/faculty\/wetzler\/\">Wetzler Lab<\/a><\/p>\n<p>My interests lie in vaccine development. As a member of the Wetzler Lab, I am involved in the development of vaccines towards the human pathogen <i>Neisseria gonorrhoeae <\/i>(Ng), the causative agent of the sexually transmitted disease, gonorrhea.<i> \u00a0<\/i>Over 300,000 cases of gonorrhea are reported per year in the US, with estimates that the disease burden may be twice as much.\u00a0 Worldwide there are estimates that there are over 60 million cases worldwide. Gonorrhea can present as urethritis in men and more seriously, pelvic inflammatory disease with infertility as a possible outcome in women. While this disease is treatable with antibiotics, the rapid development of resistance has led the CDC to identify Ng as an \u201cimmediate public health threat that requires urgent and aggressive action\u201d towards new therapeutics and vaccines. This drive for innovation faces a significant challenge in the human-specific adaptations of Ng. We are working with our collaborators to develop a humanized transgenic mouse model of disease that will serve as the platform for our future testing of <i>Neisseria gonorrhoeae <\/i>vaccine antigen candidates, which we are currently evaluating.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>MD\/PhD in Microbiology BS, University of Denver Wetzler Lab My interests lie in vaccine development. As a member of the Wetzler Lab, I am involved in the development of vaccines towards the human pathogen Neisseria gonorrhoeae (Ng), the causative agent of the sexually transmitted disease, gonorrhea. \u00a0Over 300,000 cases of gonorrhea are reported per year [&hellip;]<\/p>\n","protected":false},"author":6648,"featured_media":0,"parent":2457,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/pages\/2614"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/users\/6648"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/comments?post=2614"}],"version-history":[{"count":2,"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/pages\/2614\/revisions"}],"predecessor-version":[{"id":2829,"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/pages\/2614\/revisions\/2829"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/pages\/2457"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/immunology\/wp-json\/wp\/v2\/media?parent=2614"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}