{"id":4463,"date":"2012-02-07T15:00:28","date_gmt":"2012-02-07T20:00:28","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/im-residency\/?p=4463"},"modified":"2012-02-07T15:00:28","modified_gmt":"2012-02-07T20:00:28","slug":"thrombocytopenia","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/im-residency\/2012\/02\/07\/thrombocytopenia\/","title":{"rendered":"Thrombocytopenia"},"content":{"rendered":"<p>A 34 year-old Turkish man with PMHx of testicular CA (stage III and s\/p BEP chemotherapy regimen and surgical excision), \u00a0presents to BMC with a rash on arms and legs and bleeding m0uth. He was recently started on an H2 blocker for GERD-like symptoms. In a 5 day span, his platelet count dropped from &gt; 200k to 13k.<\/p>\n<p>What is on the differential diagnosis for his thrombocytopenia? The most likely causes appear to be drug-related vs. ITP. His testicular cancer was an unlikely source given his remission and lack of other symptoms. He failed to respond to platelet transfusion and discontinuing the H2-blocker (ranitidine). This indicates a process that is consuming platelets rather than a production problem. Therefore, the team speculated that this may be an ITP-like reaction to the medication. Steroids were began and we await further improvements in his cell counts.<\/p>\n<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16711312\">Thrombocytopenia\u00a0in adults: A practical approach to evaluation and management<\/a> &#8211;\u00a0South Med J. 2006\u00a0May;99(5):491-8; quiz 499-500, 533.<\/p>\n<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21455428\">Ranitidine-induced\u00a0thrombocytopenia: A rare drug reaction<\/a> &#8211;\u00a0Indian J Pharmacol. 2011 Feb;43(1):76-7.<br \/>\nA case report from India<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A 34 year-old Turkish man with PMHx of testicular CA (stage III and s\/p BEP chemotherapy regimen and surgical excision), \u00a0presents to BMC with a rash on arms and legs and bleeding m0uth. He was recently started on an H2 blocker for GERD-like symptoms. In a 5 day span, his platelet count dropped from &gt; [&hellip;]<\/p>\n","protected":false},"author":4816,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[4854],"tags":[4861],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/im-residency\/wp-json\/wp\/v2\/posts\/4463"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/im-residency\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/im-residency\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/im-residency\/wp-json\/wp\/v2\/users\/4816"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/im-residency\/wp-json\/wp\/v2\/comments?post=4463"}],"version-history":[{"count":0,"href":"https:\/\/www.bumc.bu.edu\/im-residency\/wp-json\/wp\/v2\/posts\/4463\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/im-residency\/wp-json\/wp\/v2\/media?parent=4463"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/im-residency\/wp-json\/wp\/v2\/categories?post=4463"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/im-residency\/wp-json\/wp\/v2\/tags?post=4463"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}