{"id":2471,"date":"2019-08-13T15:22:17","date_gmt":"2019-08-13T19:22:17","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/hematology\/?page_id=2471"},"modified":"2020-10-16T15:41:44","modified_gmt":"2020-10-16T19:41:44","slug":"2471-2","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/hematology\/research\/2471-2\/","title":{"rendered":""},"content":{"rendered":"<h4 style=\"text-align: center;\"><strong>Translational Research Laboratory and Biospecimen Repository<\/strong><\/h4>\n<p>Translational research laboratory is designed to support research studies done by faculty investigators individually or in collaboration with academic\/industry partners to take full advantage of the potential for research on human biological material at Boston Medical Center to generate research-based knowledge aiming at understanding hematology &amp; oncology diseases.<\/p>\n<p>The biospecimen repository provides long-term storage of human biological research material including blood, nasal and buccal swabs, saliva, stool, tissue, and etc. in -80\u00b0 C and liquid nitrogen freezers for research purposes.<\/p>\n<p><span style=\"color: #003366;\"><strong>Services Offered:<\/strong><\/span><\/p>\n<ul>\n<li>Consenting and enrolling subjects to translational research studies<\/li>\n<li>Processing of biological specimens<\/li>\n<li>Shipping biological specimens<\/li>\n<li>Coordinating with other laboratories and CROs (contract research organizations) for specimen testing and analysis according to the study protocol<\/li>\n<li>Short and long-term liquid nitrogen and -80\u00b0C storage of specimens in monitored freezer<\/li>\n<li>Creating and maintaining clinical databases<\/li>\n<li>Writing and submitting IRB application<\/li>\n<li>Assisting with IRB application maintenance (amendments and annual report)<\/li>\n<li>Assisting with research protocol development and proposals writing<\/li>\n<li>Assisting with paper writing and publication<\/li>\n<li>Providing research budget estimation<\/li>\n<\/ul>\n<p><span style=\"color: #003366;\"><strong>Current Projects:<\/strong><\/span><\/p>\n<ul>\n<li><em>Prospective collection of microbiome and associated biologic samples in patients with malignancies and hematologic diseases.\u00a0<\/em>PI: Dr. Matthew Kulke<\/li>\n<\/ul>\n<ul>\n<li><em>Multidimensional IO markers of response and resistance to checkpoint inhibition.\u00a0<\/em>PI: Dr. Matthew Kulke<\/li>\n<\/ul>\n<ul>\n<li><em>Determination of genomic alterations in circulating cell-free DNA (cfDNA) associated with resistance to androgen-directed therapies in African American men with metastatic castration-resistant Prostate Cancer (mCRPC).\u00a0<\/em>PI: Dr. Gretchen Gignac, Dr. Josh Campbell<\/li>\n<\/ul>\n<ul>\n<li><em>Barriers to breast cancer care: A survey study.\u00a0<\/em>PI: Dr. Naomi Ko<\/li>\n<\/ul>\n<ul>\n<li><em>Assessing the serotonin metabolism pathway in intra\/extrahepatic cholangiocarcinoma and gallbladder cancer.\u00a0<\/em>PI: Dr. Matthew Kulke<\/li>\n<\/ul>\n<ul>\n<li><em>Single cell RNA Sequensing of solid tumors.\u00a0<\/em>PI: Dr. Matthew Kulke, Dr. George Murphy<\/li>\n<\/ul>\n<ul>\n<li><em>Qualitative interviews to understand trauma history and resilience in a population of breast cancer patients at Boston Medical Center.\u00a0<\/em>PI: Dr. Naomi Ko<\/li>\n<\/ul>\n<p><strong>Contact:<\/strong><\/p>\n<p><strong>Principal Investigator:<\/strong> Matthew Kulke, MD<\/p>\n<p><strong>Program Manager<\/strong>: Kiana Mahdaviani, PhD<br \/>\n<span><a href=\"mailto:Kiana.mahdaviani@bmc.org\">Kiana.mahdaviani@bmc.org<\/a><\/span><br \/>\n617-638-7599<\/p>\n<p><strong>Research Assistants:<\/strong><br \/>\nCasey Lu Simon-Plumb<br \/>\n<span><a href=\"mailto:CaseyLu.Simon-Plumb@bmc.org\">CaseyLu.Simon-Plumb@bmc.org<\/a><\/span><br \/>\n617-638-7587<\/p>\n<p>David Li<br \/>\n<span><a href=\"mailto:David.Li@bmc.org\">David.Li@bmc.org<\/a><\/span><br \/>\n617-638-7511<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Translational Research Laboratory and Biospecimen Repository Translational research laboratory is designed to support research studies done by faculty investigators individually or in collaboration with academic\/industry partners to take full advantage of the potential for research on human biological material at Boston Medical Center to generate research-based knowledge aiming at understanding hematology &amp; oncology diseases. The [&hellip;]<\/p>\n","protected":false},"author":6467,"featured_media":0,"parent":5,"menu_order":18,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/hematology\/wp-json\/wp\/v2\/pages\/2471"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/hematology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/hematology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/hematology\/wp-json\/wp\/v2\/users\/6467"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/hematology\/wp-json\/wp\/v2\/comments?post=2471"}],"version-history":[{"count":13,"href":"https:\/\/www.bumc.bu.edu\/hematology\/wp-json\/wp\/v2\/pages\/2471\/revisions"}],"predecessor-version":[{"id":2484,"href":"https:\/\/www.bumc.bu.edu\/hematology\/wp-json\/wp\/v2\/pages\/2471\/revisions\/2484"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/hematology\/wp-json\/wp\/v2\/pages\/5"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/hematology\/wp-json\/wp\/v2\/media?parent=2471"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}