{"id":696,"date":"2010-01-19T10:21:29","date_gmt":"2010-01-19T15:21:29","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/gsi\/?p=696"},"modified":"2010-01-19T10:21:29","modified_gmt":"2010-01-19T15:21:29","slug":"mutant-ctrc-gene-has-a-new-way-to-trigger-pancreatitis","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/gsi\/2010\/01\/19\/mutant-ctrc-gene-has-a-new-way-to-trigger-pancreatitis\/","title":{"rendered":"Mutant CTRC gene has a new way to trigger pancreatitis"},"content":{"rendered":"<p>GSI faculty member <strong>Miklos Sahin-Toth<\/strong> and colleague (Department of Molecular &amp; Cell Biology, GSDM) have demonstrated that misfolding of mutant digestive enzymes also kills acinar cells \u2014those that make and give out digestive enzymes.  <a href=\"http:\/\/www.bu.edu\/phpbin\/news\/releases\/display.php?id=1987\" target=\"_blank\">Click here for details<\/a>.\u00a0  Szmola R, Sahin-Toth M. Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells. Gut. 2009 Nov 30. [Epub ahead of print] PubMed PMID: 19951900<\/p>\n","protected":false},"excerpt":{"rendered":"<p>GSI faculty member Miklos Sahin-Toth and colleague (Department of Molecular &amp; Cell Biology, GSDM) have demonstrated that misfolding of mutant digestive enzymes also kills acinar cells \u2014those that make and give out digestive enzymes. Click here for details.\u00a0 Szmola R, Sahin-Toth M. Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells. [&hellip;]<\/p>\n","protected":false},"author":1231,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/gsi\/wp-json\/wp\/v2\/posts\/696"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/gsi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/gsi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/gsi\/wp-json\/wp\/v2\/users\/1231"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/gsi\/wp-json\/wp\/v2\/comments?post=696"}],"version-history":[{"count":4,"href":"https:\/\/www.bumc.bu.edu\/gsi\/wp-json\/wp\/v2\/posts\/696\/revisions"}],"predecessor-version":[{"id":707,"href":"https:\/\/www.bumc.bu.edu\/gsi\/wp-json\/wp\/v2\/posts\/696\/revisions\/707"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/gsi\/wp-json\/wp\/v2\/media?parent=696"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/gsi\/wp-json\/wp\/v2\/categories?post=696"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/gsi\/wp-json\/wp\/v2\/tags?post=696"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}