2015 Seed Grant Application Open

SEED GRANT: Application Due April 10, 2015

The Genome Science Institute is pleased to announce the availability of one year seed grants ranging up to $20,000; each to enhance genetics and genomics research at Boston University/Boston Medical Center. These grants are intended to provide the resources needed to generate preliminary data prior to the submission of extramural grants (e.g., R01s or P01s).

PURPOSE AND SCOPE: This RFA is intended to stimulate the expansion of genetics and genomics research by enabling the generation of preliminary data and establishing collaborations so they can be convincingly presented in extramural grant applications. We encourage applicants to seek opportunities to

ELIGIBLITY: The RFA is open to all BU faculty on the Medical or Charles River campuses. Joint PIs are allowed. For faculty-level applicants, at least one PI must have been a GSI member for the six months prior to the submission deadline. (Exceptions for new faculty will be considered.) The GSI is open to all BU faculty engaged in genetics and/or genomics research. Please contact gsi@bu.edu to apply.

APPLICATION INSTRUCTIONS:

  1. A two-page application outlining the specific aims, rationale, background (brief) and methodology (brief) of the project.
  2. A one-page summary describing the expertise of the individuals involved.
  3. NIH four-page Biosketch including other support information for all participants.
  4. A detailed budget. Requests can be made only for support staff and/or supplies (i.e., not faculty salaries).
  5. Appropriate IRB/Animal Studies Approval.
  6. Application should be sent to gsi@bu.edu by 5:00 PM on Friday, April 10, 2015.

REVIEW PROCESS: Applications will be reviewed for scientific merit and potential importance in the field of genetics and genomics. Applications will be ranked by the GSI Seed Grant Committee and funding level determined by the GSI directors. A summary of the discussion is available by contacting the seed committee chair after the review. Anyone with a Conflict of Interest with a potential reviewer should make appropriate notes in the application.

REPORTING: Individuals who are funded should appropriately acknowledge support of the GSI in publications and grant applications that arise from this project. A 1-2 page progress report outlining the work carried out, as well as a basic breakdown of how funds have been spent is due 24 months from the date of award. (Although, individuals may be asked to provide this sooner.) Individuals will also be required to give a seminar in the GSI seminar series reporting their findings.

Finally, individuals are required to notify the GSI if any of the work conducted as a result of a GSI seed grant contributes in any way to either a publication or a subsequent award. This allows the GSI to measure the effectiveness of this program.

GSI Research Symposium 2021 Recap

We thank everyone who attended and participated in the 13th Annual GSI Research Symposium held virtually on November 18, 2021.

There were 112 registrations and an average 58 concurrent viewers this year over the span of the online symposium.  It began with a special tribute to remember our late colleague, Kimberlin Humphrey-Kiger, who passed away on October 24, 2021.

The morning session began with 10 superb lightning talks by graduate students, and then the afternoon session of lightning talks was rounded out with undergraduate, graduate, postdocs and staff presenting their genomics research from various basic research departments and graduate programs.

In between the lightning talks, we had Dean Dr. Karen Antman speak her special remarks, Charlie Jahnke from Research Computing Services highlighted BU's computational infrastructure supporting genomics, and we had a fantastic set of invited talks from GSI-supported COVID19 research projects and some new BU faculty working in the genetics and genomics fields.

Thanks to Illumina, the GSI and MSR held an RNA-seq award contest, and the winners are:

Adeline Matschulat (Varelas lab, Biochemistry), Allison Tipton (Russek lab, Pharm & Exp. Ther), Megan Snyder (Sherr lab, Environ. Health), Anna Berenson (Fuxman Bass lab, Biology CRC),  Jacob Beierle (Bryant lab, Pharm & Exp. Ther),  and  Dmitry Ketrov (Cifuentes lab, Biochemistry).

Thank you to all who participated and attended our event!

If you wish to view the recording of the GSI symposium, you can view the recording here

Access Passcode: @qVLp?j6

SARS-CoV2 Research Initiatives

Because of the ongoing COVID19 pandemic this FY21, the BU Genome Science Institute carried out a specially-directed research initiative to support three projects with clear genomics components matching our priorities towards combating SARS-CoV2.

 

  1. Dr. John Connor (PhD, BUSM Dept of Microbiology, NEIDL Investigator, GSI faculty member) for the BU CoGSofHoPe project (Coronavirus Genome Surveillance of Hospital Personnel). GSI has supported this project with library construction reagents and sequencing efforts to monitor the genomes of SARS-CoV2 virus samples within the BMC and BU community.
  2. Dr. Nader Rahimi (PhD. Department of Pathology, GSI Faculty member) for the project studying Lectins, SARS-CoV-2 and Endothelial Cell Injury.
  3. Dr. Andrew Emili (Professor of Biology and Biochemistry; Director, Center for Network Systems Biology) for the project describing Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2 .

 

We congratulate all three PI’s and their labs for advancing our understanding of SARS-CoV2 virus biology and look forward to hearing their work in combating this pandemic while preparing better for potential future pandemics.

 

IPA Training Workshop, May 19, 2021 from 12-3pm

GSI will be collaborating with QIAGEN Digital Insights (QDI) to host an Ingenuity Pathway (IPA) Virtual Training for all active users on Wednesday May 19th from 12-3pm. QIAGEN trainer Sumana Chintalapudi will provide an introduction to IPA, data reduction & core analysis features, and a brief Q&A & introduction to the Lands Explorer feature. Please email gsi@bu.edu for more details.

Ingenuity IPA Software Access Starting April 1, 2021

We are pleased to announce that the GSI will be renewing our license with Qiagen for Ingenuity Pathway Analysis (IPA) for the upcoming year. As part of the renewal, we have upgraded our license to include IPA Analysis Match which will allow users to not only quickly visualize and understand complex ‘omics data, but will also allow users to place these results within the context of biological systems. Over the course of the past year we have been working closely with Qiagen to ensure a seamless transition to our new license as well as improved accessibility for the GSI community. If you are interested in IPA Analysis Match for your research please contact gsi@bu.edu for details on both trial and full access site licenses.

Fee Schedule
IPA trial License: Trial license allows free access to IPA Analysis Match for 2-weeks. This allows users the opportunity to explore IPA on a limited basis to determine whether the platform meets their research needs. This license can then be expanded to a full site license, see below.

Full Site License: for access to the full site license we require an $800 buy-in from a sponsoring PI. The sponsoring PI will then be allowed to provide access to a maximum of 6 trainees. Each trainee will use their own login credentials to access IPA Analysis Match. Each BU email account allows installation on up to 3 devices.

For scheduling details and inquiries about this new program, please email gsi@bu.edu.

GSI Research Symposium 2020 Recap

The Annual GSI Research Symposium was successfully held virtually on November 14th, 2020.

There were 111 registrations and an average 56 concurrent viewers over the span of the webinar event.  The symposium began with a word from our sponsor, Illumina, with a Slide Presentation introducing the new NextSeq2000 system now here at the BUSM Microarray and Sequencing Resource (MSR).

After Dean Dr. Karen Antman kicked off the symposium with opening remarks, we had a fantastic set of talks from several new BU faculty working in the genetics and genomics fields in the first session.  There were then 16 superb lightning talks by graduate students and postdocs from the various basic research departments and graduate programs.  If you wish to view the recording of the GSI symposium, please email gsi@bu.edu for the link to the video.

Thanks to Illumina, the GSI and MSR held an RNA-seq award contest, and the winners are:

Kristyn  Borrelli (Bryant lab, Pharm & Exp. Ther),  Joseph Kern (Varelas lab, Biochem),  Stephen Ross (Muhlberger lab, Microbiology), Marc Vittoria (Ganem lab, Pharm & Exp. Ther) and  Ana Fiszbein (Faculty, Biology CRC).

Thank you to all who participated and attended our event!

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  • Snapshots of the GSI Research Symposium Virtual edition

 

 

Learn QIAGEN IPA and CLC Workbench to generate hypotheses and insights for publications and grant renewals

Qiagen is holding an upcoming Zoom training from QIAGEN Digital Insights. Qiagen will provide no-cost trial access to our platforms, live demonstrations, and customized training.

Their next training will be in two sessions, the first using the CLC bio platform for sequence analysis of viral isolates, followed by a review of Ingenuity Pathway Analysis (IPA) on host responses.

On July 22nd there will be two training sessions.

Morning Session 10:30 AM to 12:00 PM: CLC Bio Platform

· Introduction to CLC bio
· Resequencing in CLC bio fundamentals
· Resequencing the SARS-COVID-19 virus
· Quick primer on HOST Resequencing/RNAseq of COVID Patients

Afternoon Session 1:00 PM to 2:30 PM: Pathway Analysis and Interpretation

· Introduction to QIAGEN Knowledge Base
· Analysis and interpretation of RNA-seq data
· Determining relevant pathways targeted by infection
· Identification of key upstream regulators and biological processes related to infection
· Finding isoforms that have a role in antiviral immune response
· Exploring trends across published data sets with Analysis Match

Register in advance for this webinar:
https://qiagen.zoom.us/webinar/register/WN_GY077VWqSpuFn8phVGat3w

The contact for this event is below
Khushbu Kariwala
Account Manager- QIAGEN Digital Insights – Inside Sales
QIAGEN | 1001 Marshall Street | Redwood City, CA 94063 | USA
Phone: +1-415-6833-216
khushbu.kariwala@qiagen.com

GSI Workshop Competition 2020 Winners

The Genome Science Institute is excited to announce the winners of our second annual Workshop Competition! For full details on the competition and our partners that made the competition possible, check out our official announcement here!

  1. scRNA-seq Award, theme - "Invertebrates": “Genomic analysis of brain evolution and complex social behavior: leveraging the power of single-cell RNA sequencing to understand functional neuroplasticity”
    Sean Mullen, Ph.D. and James Traniello, Ph.D.
    BU Dept of Biology

  2. scRNA-seq Award, theme – "Neurobiology": “Deciphering Down Syndrome (DS)-related abnormalities in the white matter using a novel platform.”
    Ella Zeldich Ph.D. and Tarik Haydar, Ph.D.
    BUSM Dept of Anatomy and Neurobiology

  3. scRNA-seq Award, theme – "Immunology": “Perform benchmark study of novel unbiased single cell surface proteome and transcriptome profiling technology.”
    Julian Kwan, Ph.D. Dylan Steiner, and Andrew Emili, Ph.D.
    BUSM Dept of Biochemistry and BU Biology

  4. scRNA-seq Award, theme – "Cancer and Stem Cells": “Defining cellular changes driving basal-like breast cancer initiation and invasion”
    Bob Varelas Ph.D.
    BUSM Dept of Biochemistry

  5. scRNA-seq Award, theme – "Lung and Fibrosis": “Time series scRNA-seq to dissect the fate decisions of human foregut patterning.”
    Taylor Matte and Finn Hawkings, MBBCh.
    BUSM Dept of Medicine, Pulmonary Center, and CReM

 

GSI Symposium Live Feed!

Can't make it to the symposium? No problem! Click the image below to watch the oral presentations and the award ceremony.

GSI 2019 Overview

The 2019 academic year has been a great period of transition for the GSI.  We are optimistically anticipating this transition to set the foundation for a new era - GSI 2.0.

To recap some noteworthy moments from this past year, the GSI has observed extensive personnel transitions including Anita DeStefano shifting to another leadership role outside of GSI, Rick Myers blissfully entering retirement, and the previous admin, Katie McCue, receiving a promotion. Despite the GSI's sadness in seeing their team members depart ways from the GSI, it is an exciting venture receiving new blood with raw enthusiasm to facilitate change. Nelson Lau was selected as the GSI's new Director, Rachel Flynn became the new Co-Director, and Emily Piontek now supports the GSI as a financial admin.

Outside of the shift in personnel, the Annual Symposium in November 2018 was well attended in conjunction with a record company sponsorship thanks to Katie McCue, Anita DeStefano, Rick Myers, and Alla Grishok.

The GSI seminars had exceptional attendance and were able to host some spectacular scientists and academics. We are eager to note that seminar planning for this coming academic year is already underway!

In partnership with the Graduate Program in Genetics & Genomics (GPGG), the GSI was able to provide student laptops as a resource for new students that join the program. This is the first time the GPGG/GSI has been able to offer this kind of perk and we are excited for our 2 new students to have a new level of support.

Another big win for the GSI has been hosting our first-ever ddPCR and scRNAseq Workshop Grants Competition that helped researchers collaborate in new ways and incentivize experimenting with new equipment that the GSI has funded.

All of these accomplishments could never have been done without the help of combining the previous experience of the GSI's tried-and-true team members with the new ideas and enthusiasm of our newest team members. We are so grateful for all the insight given to us from Anita, Rick, and Katie and we are excited to see how our new chapter of faculty and staff take their own spin on the GSI's mission. Keep your eyes peeled for an amazing 2020 for the GSI!