{"id":75499,"date":"2020-09-25T13:58:47","date_gmt":"2020-09-25T17:58:47","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/gms\/?p=75499"},"modified":"2020-09-29T12:40:39","modified_gmt":"2020-09-29T16:40:39","slug":"gms-scientists-discover-covid-19-lung-inflammation-pathway","status":"publish","type":"post","link":"https:\/\/www.bumc.bu.edu\/gms\/2020\/09\/25\/gms-scientists-discover-covid-19-lung-inflammation-pathway\/","title":{"rendered":"GMS Scientists Discover COVID-19 Lung Inflammation Pathway"},"content":{"rendered":"<p><img loading=\"lazy\" src=\"\/gms\/files\/2020\/09\/Screen-Shot-2020-09-25-at-12.47.45-PM-636x122.png\" alt=\"\" width=\"636\" height=\"122\" class=\"size-medium wp-image-75503 aligncenter\" srcset=\"https:\/\/www.bumc.bu.edu\/gms\/files\/2020\/09\/Screen-Shot-2020-09-25-at-12.47.45-PM-636x122.png 636w, https:\/\/www.bumc.bu.edu\/gms\/files\/2020\/09\/Screen-Shot-2020-09-25-at-12.47.45-PM-1024x197.png 1024w, https:\/\/www.bumc.bu.edu\/gms\/files\/2020\/09\/Screen-Shot-2020-09-25-at-12.47.45-PM-768x148.png 768w, https:\/\/www.bumc.bu.edu\/gms\/files\/2020\/09\/Screen-Shot-2020-09-25-at-12.47.45-PM-1536x296.png 1536w, https:\/\/www.bumc.bu.edu\/gms\/files\/2020\/09\/Screen-Shot-2020-09-25-at-12.47.45-PM-2048x394.png 2048w\" sizes=\"(max-width: 636px) 100vw, 636px\" \/><\/p>\n<p>Scientists, including GMS faculty, at <a href=\"https:\/\/www.bu.edu\/neidl\/\">NEIDL<\/a> and <a href=\"https:\/\/www.bu.edu\/dbin\/stemcells\/\">CReM<\/a> have uncovered how COVID-19 triggers severe lung inflammation. Their research points to the body&#8217;s NFkB signaling pathway as the driver of this response. In discovering this, they are opening the door to therapeutic research that could reduce inflammation before it becomes deadly. In the words of Dr. Andrew Wilson (one of the co-corresponding authors of the study), &#8220;<span>It\u2019s been wonderful to finally be on the offense, rather than on the defense, like we were early on in April and May.&#8221;<\/span><\/p>\n<p><a href=\"https:\/\/www.bu.edu\/articles\/2020\/in-deadly-covid-19-lung-inflammation-bu-researchers-discover-a-culprit-in-nfkb-pathway\/\">Read more<\/a> about their research, as well as their use of organoid models derived from stem cells.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists, including GMS faculty, at NEIDL and CReM have uncovered how COVID-19 triggers severe lung inflammation. Their research points to the body&#8217;s NFkB signaling pathway as the driver of this response. In discovering this, they are opening the door to therapeutic research that could reduce inflammation before it becomes deadly. In the words of Dr. [&hellip;]<\/p>\n","protected":false},"author":15019,"featured_media":75565,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[7158,7154,54],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/gms\/wp-json\/wp\/v2\/posts\/75499"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/gms\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/gms\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/gms\/wp-json\/wp\/v2\/users\/15019"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/gms\/wp-json\/wp\/v2\/comments?post=75499"}],"version-history":[{"count":4,"href":"https:\/\/www.bumc.bu.edu\/gms\/wp-json\/wp\/v2\/posts\/75499\/revisions"}],"predecessor-version":[{"id":75509,"href":"https:\/\/www.bumc.bu.edu\/gms\/wp-json\/wp\/v2\/posts\/75499\/revisions\/75509"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/gms\/wp-json\/wp\/v2\/media\/75565"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/gms\/wp-json\/wp\/v2\/media?parent=75499"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/gms\/wp-json\/wp\/v2\/categories?post=75499"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/gms\/wp-json\/wp\/v2\/tags?post=75499"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}