{"id":1089,"date":"2020-01-10T20:55:23","date_gmt":"2020-01-11T01:55:23","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/geriatrics\/?page_id=1089"},"modified":"2020-01-10T20:55:23","modified_gmt":"2020-01-11T01:55:23","slug":"safety-and-immunogenicity-of-adjuvanted-versus-high-dose-inactivated-influenza-vaccines-in-older-adults","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/geriatrics\/research\/current\/safety-and-immunogenicity-of-adjuvanted-versus-high-dose-inactivated-influenza-vaccines-in-older-adults\/","title":{"rendered":"Safety and Immunogenicity of Adjuvanted versus High-Dose Inactivated Influenza Vaccines in Older Adults"},"content":{"rendered":"<p>Funded by the Centers for Disease Control &amp; Prevention Clinical Immunization Safety Assessment (CISA), this randomized, blinded clinical trial works to assess the safety and immunogenicity of adjuvanted inactivated influenza vaccine (aIIV3) versus High-Dose inactivated influenza vaccine (IIV3-HD) in subjects aged \u226565 years. Duke University and BMC are the two study sites.<br \/>\nOlder adults are at high risk for influenza-related morbidity and mortality due to immunosenescence (decreased immune responses with age), multi-morbidity, specific age-related diseases (e.g. congestive heart failure, chronic lung disease) and age-related changes in compensatory physiologic responses to inflammatory states. Although the incidence of influenza is usually higher in younger adults and children than older adults, 90% of influenza-related deaths occur in older adults.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Funded by the Centers for Disease Control &amp; Prevention Clinical Immunization Safety Assessment (CISA), this randomized, blinded clinical trial works to assess the safety and immunogenicity of adjuvanted inactivated influenza vaccine (aIIV3) versus High-Dose inactivated influenza vaccine (IIV3-HD) in subjects aged \u226565 years. Duke University and BMC are the two study sites. Older adults are [&hellip;]<\/p>\n","protected":false},"author":14042,"featured_media":0,"parent":609,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/geriatrics\/wp-json\/wp\/v2\/pages\/1089"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/geriatrics\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/geriatrics\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/geriatrics\/wp-json\/wp\/v2\/users\/14042"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/geriatrics\/wp-json\/wp\/v2\/comments?post=1089"}],"version-history":[{"count":1,"href":"https:\/\/www.bumc.bu.edu\/geriatrics\/wp-json\/wp\/v2\/pages\/1089\/revisions"}],"predecessor-version":[{"id":1090,"href":"https:\/\/www.bumc.bu.edu\/geriatrics\/wp-json\/wp\/v2\/pages\/1089\/revisions\/1090"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/geriatrics\/wp-json\/wp\/v2\/pages\/609"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/geriatrics\/wp-json\/wp\/v2\/media?parent=1089"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}