FTMS has traditionally been constructed on large, horizontal, room temperature bore magnets, but if it is possible to construct the FTMS in the 4.2K cold bore of a superconducting magnet, several important advantages will be achieved.<\/p>\n
First, the vacuum system will cryopump itself so the base pressure will be in the <1012<\/sup> mbar range and the pumping speed will be in the 105<\/sup> l\/sec range. Second, the cold vacuum system walls can be placed in thermal contact with the input resistors of a preamplifier. This will reduce thermal Johnson noise by a factor of 8.4 relative to room temperature operation which increases sensitivity and dynamic range by the same amount. Third, the vacuum system can be constructed in a 1″-2″ diameter bore which allows the use of NMR-style magnets for FTMS. Thus, the high field NMR magnets up to 23.3T can be used for FTMS without any change to the fundamental coil design.<\/p>\n The original design of a cryoFTMS system was discussed in the reference below.<\/p>\n O’Connor, P. B. Considerations for the Design of a Fourier Transform Mass Spectrometer in the 4.2K Cold Bore of a Superconducting Magnet Rapid Commun Mass Spectrom<\/em> 2002<\/strong>, 16<\/em>, 1160-1167. Link<\/a><\/p>\n To Download some recent pictures of the cryogenic FTMS vacuum chamber, click here.<\/a><\/p>\n After overcoming substantial electrical and mechanical engineering obstacles, the 14 T cryogenic MALDI-FTMS instrument has finally achieved first signal. The press release can be found here<\/a>. The reference below describes this research in detail.<\/p>\n Lin, C.; Mathur, R.; Aizikov, K.; O\u2019Connor, P. B. First Signal on the Cryogenic Fourier-Transform Ion Cyclotron Resonance Mass Spectrometer J. Am. Soc. Mass Spectrom.<\/em> 2007<\/strong>, 18<\/em>, 2090-2093. Link<\/a><\/p>\n","protected":false},"excerpt":{"rendered":" FTMS has traditionally been constructed on large, horizontal, room temperature bore magnets, but if it is possible to construct the FTMS in the 4.2K cold bore of a superconducting magnet, several important advantages will be achieved. First, the vacuum system will cryopump itself so the base pressure will be in the <1012 mbar range and […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":16,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/ftms\/wp-json\/wp\/v2\/pages\/50"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/ftms\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/ftms\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ftms\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/ftms\/wp-json\/wp\/v2\/comments?post=50"}],"version-history":[{"count":11,"href":"https:\/\/www.bumc.bu.edu\/ftms\/wp-json\/wp\/v2\/pages\/50\/revisions"}],"predecessor-version":[{"id":982,"href":"https:\/\/www.bumc.bu.edu\/ftms\/wp-json\/wp\/v2\/pages\/50\/revisions\/982"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/ftms\/wp-json\/wp\/v2\/media?parent=50"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}