{"id":3050,"date":"2024-10-24T12:13:50","date_gmt":"2024-10-24T16:13:50","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/fhs-bap\/?page_id=3050"},"modified":"2024-11-21T07:36:44","modified_gmt":"2024-11-21T12:36:44","slug":"clinical-core","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/fhs-bap\/research\/programs-and-cores\/clinical-core\/","title":{"rendered":"Clinical Core"},"content":{"rendered":"

Clinical Core Leadership:<\/p>\n

\"\"<\/a>
Ashita Gurnani, PhD<\/figcaption><\/figure>\n
\"\"<\/a>
Jesse Mez, MD, MS<\/figcaption><\/figure>\n
\"Rhoda<\/a>
Rhoda Au, PhD<\/figcaption><\/figure>\n

The Clinical Core plays a pivotal role in our ongoing dementia research. Our primary objectives include:<\/p>\n

    \n
  • Surveillance and Diagnosis:<\/strong> Continuously monitoring FHS cohorts for incident dementia and conducting comprehensive diagnostic assessments.<\/li>\n
  • Longitudinal Characterization:<\/strong> Extending our understanding of cognitive function and brain structure across FHS cohorts.<\/li>\n
  • Ante-Mortem Support:<\/strong> Providing comprehensive support for the brain donation program.<\/li>\n<\/ul>\n

    Key Achievements:<\/strong><\/p>\n

      \n
    • Surveillance and Diagnosis:<\/strong> Conducted 699 participant chart “death reviews” and administered neuropsychological testing to 1489 participants.<\/li>\n
    • Brain Imaging:<\/strong> Conducted 791 structural brain MRI scans and defaced 5629 FHS MRIs for Freesurfer reprocessing.<\/li>\n
    • Ante-Mortem Support:<\/strong> Supported 32 brain donors and facilitated 8 clinicopathological conferences.<\/li>\n
    • Clinical Core Extensions:<\/strong> Developed a remote neuropsychological testing protocol, expanded the neurological examination, and translated testing materials into Mandarin and Cantonese.<\/li>\n<\/ul>\n

      Future Directions:<\/strong><\/p>\n

        \n
      • Digital Phenotyping:<\/strong> Piloting a study to develop remote neuropsychological testing protocols using smartphones.<\/li>\n
      • Data Science:<\/strong> Developing new methods for processing digital voice and pen data to quantify Boston Process Approach measures.<\/li>\n
      • Parkinson’s Disease Review:<\/strong> Strengthening protocols for flagging and case presentation for Parkinson’s Disease diagnosis.<\/li>\n<\/ul>\n

        By combining innovative research methods with a strong commitment to participant care, the Clinical Core is making significant strides in advancing our understanding of dementia and improving the lives of affected individuals.<\/p>\n

        \"\"<\/p>\n","protected":false},"excerpt":{"rendered":"

        Clinical Core Leadership: The Clinical Core plays a pivotal role in our ongoing dementia research. Our primary objectives include: Surveillance and Diagnosis: Continuously monitoring FHS cohorts for incident dementia and conducting comprehensive diagnostic assessments. Longitudinal Characterization: Extending our understanding of cognitive function and brain structure across FHS cohorts. Ante-Mortem Support: Providing comprehensive support for the […]<\/p>\n","protected":false},"author":22858,"featured_media":0,"parent":2730,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"page-templates\/no-sidebars.php","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/fhs-bap\/wp-json\/wp\/v2\/pages\/3050"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/fhs-bap\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/fhs-bap\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/fhs-bap\/wp-json\/wp\/v2\/users\/22858"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/fhs-bap\/wp-json\/wp\/v2\/comments?post=3050"}],"version-history":[{"count":3,"href":"https:\/\/www.bumc.bu.edu\/fhs-bap\/wp-json\/wp\/v2\/pages\/3050\/revisions"}],"predecessor-version":[{"id":3167,"href":"https:\/\/www.bumc.bu.edu\/fhs-bap\/wp-json\/wp\/v2\/pages\/3050\/revisions\/3167"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/fhs-bap\/wp-json\/wp\/v2\/pages\/2730"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/fhs-bap\/wp-json\/wp\/v2\/media?parent=3050"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}