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The Neuropathology Core is dedicated to advancing our understanding of neurodegenerative diseases. Our primary objectives include:<\/p>\n
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- Comprehensive Neuropathological Evaluation:<\/strong> Conducting in-depth examinations of brain tissue from donors with and without dementia or Alzheimer’s disease (AD).<\/li>\n
- Digital Pathology Library:<\/strong> Creating a digital repository of pathology slides for easy access and analysis.<\/li>\n
- Novel Method Development:<\/strong> Developing innovative techniques for qualitative and quantitative histopathological characterization of brain tissue.<\/li>\n<\/ul>\n
Key Achievements:<\/strong><\/p>\n
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- Tissue Acquisition:<\/strong> Received 8 new cases over the past year, bringing the total to 288.<\/li>\n
- Data Management:<\/strong> Entered neuropathological data into REDCap, a database compatible with the National Alzheimer’s Coordinating Center (NACC), and generated reports for families.<\/li>\n
- Automation:<\/strong> Developed an automated report generation system from REDCap data.<\/li>\n
- Tissue Distribution:<\/strong> Implemented a rigorous tissue request review process and distributed samples to 2 investigators.<\/li>\n
- Research Output:<\/strong> Supported 8 original peer-reviewed publications and 7 currently funded grants.<\/li>\n
- Quantitative Analysis:<\/strong> Conducted detailed staining analyses and developed AI tools for analyzing pathologic density and cell types.<\/li>\n
- Machine Learning:<\/strong> Utilized quantitative protein densities for machine learning-driven disease progression modeling.<\/li>\n
- SuStaIn:<\/strong> Developed a machine learning toolset to model neuropathology progression through the brain.<\/li>\n<\/ul>\n
Future Goals:<\/strong><\/p>\n
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- Tissue Distribution:<\/strong> Streamlining tissue distribution processes and communication with the Brain Tissue Repository Oversight Committee (BROC) and Data Team.<\/li>\n
- Legacy Case Analysis:<\/strong> Completing TDP-43 and Thal assessments on legacy cases.<\/li>\n
- Digitalization:<\/strong> Completing digital slide scanning.<\/li>\n
- Vascular Pathology Assessment:<\/strong> Expanding assessments of vascular pathologies.<\/li>\n<\/ul>\n
By combining state-of-the-art techniques with a comprehensive tissue repository, the Neuropathology Core is making significant contributions to the field of neurodegenerative disease research.<\/p>\n
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- Legacy Case Analysis:<\/strong> Completing TDP-43 and Thal assessments on legacy cases.<\/li>\n
- Data Management:<\/strong> Entered neuropathological data into REDCap, a database compatible with the National Alzheimer’s Coordinating Center (NACC), and generated reports for families.<\/li>\n
- Digital Pathology Library:<\/strong> Creating a digital repository of pathology slides for easy access and analysis.<\/li>\n