Markus Bosmann, MD (PULMONARY CENTER)
Mohsan Saeed, PhD (BIOCHEMISTRY & CELL BIOLOGY, NEIDL)<\/p>\n
SARS-CoV-2 caused a global pandemic, leading to an unprecedented public health crisis within a few months. With an urgent need to gain better insights into the pathogenesis of localized SARS-CoV-2 infection in the lung and its distant organ complications, this Affinity Research Collaborative (ARC), a multi-disciplinary researcher team of Boston University (BUMC, CRC) aims to develop and test novel cell cultures systems to dissect how this virus invades the lung and other organs, how it replicates inside cells, and how it is recognized and counteracted by the host immune defence. Using mouse models of the disease, studies will also focus on life-threatening complications, such as Acute Respiratory Distress Syndrome (ARDS), sepsis, multi-organ failure, coagulopathy, and the role of co-infections, co-morbidities, sex and age. These directions will serve as a translational platform for pre-clinical models of SARS-CoV-2 infection to design innovative diagnostics, preventive agents and facilitate the drug development process. Bidirectional translational interactions between basic scientists, clinicians and epidemiologists will be embedded in the existing infrastructures, science networks and the collaborative culture of BU. In a broader perspective, this ARC initiative aspires to strengthen the preparedness for outbreaks of contagious respiratory viruses in the future. Hence, we envisioned this ARC platform to set the stage for self-sustaining extramurally funded research programs of other respiratory viral illnesses modeled on investigative pursuits carried out here.<\/p>\n
The purpose of this Affinity Research Collaborative (ARC) was to build an interdisciplinary research program focused on pandemic and endemic respiratory pathogens, including SARS-CoV-2, influenza viruses, and bacterial pathogens such as Streptococcus pneumoniae<\/em> and Legionella<\/em> spp., which collectively cause substantial global morbidity and mortality (1). The ARC was initiated during the COVID-19 pandemic, when there was an urgent need to establish experimental models, infrastructure, and collaborative networks for studying SARS-CoV-2. As the pandemic evolved, the ARC broadened its scope to address shared mechanisms of respiratory infection, host defense, pneumonia, acute respiratory distress syndrome (ARDS), and post-infectious complications.<\/p>\n Vaccines and antiviral therapies have substantially reduced the burden of severe COVID-19, but vaccination does not completely prevent infection or transmission, effectiveness varies among pathogens and emerging variants, and vaccines are not available for many respiratory pathogens. Future pandemics may also involve pathogens capable of partially evading pre-existing immunity. Continued investigation of the molecular and cellular mechanisms governing infection, host responses, tissue injury, and recovery therefore remains essential for improving diagnosis, prevention, and treatment of viral and bacterial pneumonia and ARDS.<\/p>\n During the final years of the ARC, this broader mission became increasingly important. Research activities expanded beyond SARS-CoV-2 toward other clinically important respiratory pathogens, particularly S. pneumoniae<\/em> and Legionella<\/em>, as well as influenza, and emerging respiratory viruses. This transition leveraged the infrastructure, technologies, expertise, and collaborative relationships originally established for COVID-19 research and redirected them toward sustained respiratory-pathogen preparedness.<\/p>\n Markus Bosmann, MD, Pulmonary Center Pathology & Laboratory Medicine Co-Directors Markus Bosmann, MD (PULMONARY CENTER)Mohsan Saeed, PhD (BIOCHEMISTRY & CELL BIOLOGY, NEIDL) Synopsis SARS-CoV-2 caused a global pandemic, leading to an unprecedented public health crisis within a few months. With an urgent need to gain better insights into the pathogenesis of localized SARS-CoV-2 infection in the lung and its distant organ complications, this Affinity […]<\/p>\n","protected":false},"author":1607,"featured_media":0,"parent":3331,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/pages\/3490"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/users\/1607"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/comments?post=3490"}],"version-history":[{"count":12,"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/pages\/3490\/revisions"}],"predecessor-version":[{"id":6855,"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/pages\/3490\/revisions\/6855"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/pages\/3331"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/media?parent=3490"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Members<\/h4>\n
\nMohsan Saeed, PhD, NEIDL, Biochemistry
\nKristine Abo, Post Doc,
\nYuriy Alekseyev, PhD, Clinical Pathology & Laboratory Medicine
\nKonstantinos Dionysios Alysandratos, MD, PhD, Pulmonary Center, CReM
\nManu Anantpadma, PhD, NEIDL
\nNahid Bhadelia, MD, Infectious Disease
\nKevin Brueck, PhD Student, Pulmonary
\nEric Burks, MD, Pathology & Laboratory Medicine
\nJoshua Campbell, PhD, Computational Biomedicine
\nDavid Center, MD, CTSI Director, Pulmonary Center
\nKevin Chandler, PhD, Biochemistry
\nFelicia Chen, PhD, Pulmonary
\nVipul Chitalia, MD, Medicine, Nephrology
\nDaniel Cifuentes Buira, PhD, Biochemistry
\nJohn Connor, PhD, NEIDL, Microbiology
\nRena Conti, PhD, Questrom, Markets, Public Policy & Law
\nRonald Corley, PhD, NEIDL Director
\nCatherine Costello, PhD, Center for Biomedical Mass Spectrometry Director
\nNicholas Crossland, DVM, Pathology & Laboratory Medicine
\nRobert Davey, PhD, NEIDL, Microbiology
\nLynn Deng, PhD, Research Implementation
\nFlorian Douam, PhD, NEIDL, Microbiology
\nAndrew Emili, PhD, Biology
\nKara Farquharson, PhD Student, Pulmonary
\nAlan Fine, MD, Pulmonary
\nLucien Garo, PhD student, Pulmonary Center Pathology & Laboratory Medicine
\nValerie Gouon-Evans, PhD,PharmD, Gastroenterology, CReM
\nAnthony Griffiths, PhD, NEIDL, Microbiology
\nRahm Gummuluru, PhD, NEIDL, Developmental Core Director, Providence\/Boston Center for AIDS Res (Prov\/Bos CFAR)
\nJim Hamilton, PhD, Physiology & Biophysics
\nFinn Hawkins, MBBCh, Medicine CReM
\nOlivia Tsai Hix, Resesarch Study Technician, CReM
\nJessie Huang, Post Doc, CReM
\nAdam Hume, PhD, NEIDL, Microbiology
\nElaine Hylek, MD, General Internal Medicine
\nLaertis Ikonomou, PhD, CReM, Pulmonary Center
\nKaren Jacobson, MD, MPH, Medicine
\nArchana Jayaraman,\u00a0 Post Doc, Pulmonary
\nYang Jin, MD, PhD, Medicine
\nMatthew Jones, PhD, Pulmonary Center
\nKonstantinos Kontodimas, Research Assistant, Pulmonary
\nDarrell Kotton, MD, CReM, Pulmonary Center
\nWendy Kuohung, MD, Obstetrics & Gynecology \/ Reproductive Endocrinology
\nBen Linas, MD, MPH, Infectious Diseases
\nWeining Lu, MD, MS, FASN, Pathology & Laboratory Medicine
\nJose Carlos Villacorta Martin, PhD
\nSarah Anne Mazzilli, PhD, Computational Biomedicine
\nJay Mizgerd, ScD, Pulmonary, Microbiology
\nGustavo Mostoslavsky, PhD, Gastroenterology, CReM
\nElke M\u00fchlberger, PhD, NEIDL, Microbiology, Biomolecule Production Core Director
\nMelissa Pesta, Technician, Pulmonary
\nValentina Perissi, PhD, Biochemistry
\nLee Quinton, PhD, Medicine
\nNader Rahimi, PhD, Pathology
\nVasan Ramachandran, MD, Preventative Medicine & Epidemiology Section Chief
\nKatya Ravid, DSc, Medicine, Biochemistry, Whitaker Cardiovascular Center, Boston University Interdisciplinary Biomedical Research Office & Evans Center for Interdisciplinary Biomedical Research Director
\nDaniel Remick, MD, Pathology & Laboratory Medicine
\nNathan Sanders, MD-PhD Student, Pulmonary
\nFrancesca Seta, PhD, Vascular Biology, Whitaker Cardiovascular Institute, Metabolic Phenotyping & IVIS Imaging Core Director
\nArjun Sharma, Research Fellow, Pulmonary
\nChantelle Simone, Research Assistant, Center for Biomedical Mass Spectrometry
\nSaravanan Subramaniam, PhD, Infectious Diseases and Coagulation Disorders
\nEllen Suder, PhD Student, Microbiology
\nJacquelyn Turcinov, PhD Student, NEIDL
\nKatrina Traber, Md, PhD, Medicine
\nXaralabos \u2018Bob\u2019 Varelas, PhD, Biochemistry
\nSarah Walachowski, Post Doc, Infectious Diseases and Coagulation Disorders
\nRuby Wang, MD, Pulmonary Medicine
\nRhiannon Werder, Post Doc, CReM, Pulmonary
\nLee Wetzler, MD, Infectious Diseases
\nAndrew Wilson, MD, CReM, Pulmonary
\nBen Wolozin, PhD, Pharmacology & Exp Therapeutics
\nChaoshuang Xia, Post Doc
\nGrace Zhao, MD, PhD, Chief & Vice Chair for Anatomic Pathology, Pathology & Laboratory Medicine<\/p>\n","protected":false},"excerpt":{"rendered":"