{"id":340,"date":"2010-03-09T08:35:41","date_gmt":"2010-03-09T13:35:41","guid":{"rendered":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/?page_id=340"},"modified":"2023-06-21T18:09:05","modified_gmt":"2023-06-21T22:09:05","slug":"sex-differences","status":"publish","type":"page","link":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/the-arcs\/recent-past-arc-programs-evolved-into-university-and-or-agency-funded-programs\/sex-differences\/","title":{"rendered":"Sex Differences in Adipose Tissue Biology and Related Metabolic Diseases"},"content":{"rendered":"

INITIATION DATE:<\/strong><\/h3>\n

12.01.09<\/p>\n

ARC DIRECTORS AND CO-DIRECTORS:<\/strong><\/h3>\n

Susan K. Fried, PhD; Director; Professor; Medicine\/ Endocrinology<\/p>\n

Paul Pilch, PhD; Co-Director; Professor; Biochemistry
\n <\/strong> <\/span><\/span><\/p>\n

OVERVIEW OF GOALS AND MISSION:<\/em><\/strong><\/h3>\n

Abstract<\/em><\/strong><\/em><\/h3>\n

The ARC focuses on the role of adipose tissue biology in the metabolic complications of obesity in men and women.\u00a0 Our members have complementary expertise in biochemistry, cell biology, immunology and translational research in obesity, diabetes and cardiovascular disease.\u00a0 As a graduating ARC with a close relationship to an existing NIH-funded center, the Boston Nutrition and Obesity Research Center, we have initiated novel collaborations that resulted in interdisciplinary grant proposals, including \u2018brite\u2019 adipocytes, adiporedoxin, a novel regulator adipocyte secretory function and adipocyte dysfunction in insulin resistance. We also engaged in fruitful ARC*ARC collaborations with four other ARCS: Mitochondria, Arterial Stiffness, Cancer and Inflammation, and Metabolic Disease and Insulin Resistance: Studies in Patients Undergoing Bariatric Surgery.\u00a0 There is substantial overlap in the membership of these ARCs, which reflect growing collaborations and common interests to enrich the training experiences of graduate and post-doctoral trainees.\u00a0 Thus, we hope to continue to sponsor multidisciplinary seminars and workshops to develop these collaborations and spark new ones.<\/p>\n

ARC Members:<\/strong><\/h3>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Name\/Title <\/strong>(*key personnel)<\/strong><\/b><\/td>\nDept\/School<\/strong><\/td>\nRole in ARC<\/strong><\/td>\n<\/tr>\n
Susan K Fried* <\/i><\/td>\nMedicine, Endocrinology, Diabetes & Nutrition, BUSM<\/td>\nDirector<\/i><\/td>\n<\/tr>\n
Paul Pilch* <\/i><\/td>\nBiochemistry, BUSM<\/td>\nDirector<\/i><\/td>\n<\/tr>\n
Caroline Apovian<\/a><\/td>\nMedicine, Endocrinology, Diabetes & Nutrition, BUSM<\/td>\nInvestigator<\/td>\n<\/tr>\n
Tamar Aprahamian*<\/td>\nMedicine, Renal, BUSM<\/td>\nInvestigator<\/td>\n<\/tr>\n
Barbara Corkey<\/td>\nMedicine, GI, BUSM<\/td>\nInvestigator<\/td>\n<\/tr>\n
Andrea Coviello<\/td>\nMedicine, Endocrinology, Diabetes & Nutrition, BUSM<\/td>\nInvestigator<\/td>\n<\/tr>\n
Gerald Denis<\/a><\/td>\nCancer Center, BU<\/td>\nInvestigator<\/td>\n<\/tr>\n
Stephen Farmer<\/i><\/a>*<\/td>\nBiochemistry, BUSM<\/td>\nInvestigator<\/td>\n<\/tr>\n
Andrew S. Greenberg*<\/i><\/td>\nTufts U, HNRC<\/td>\nCollaborator<\/td>\n<\/tr>\n
Ulla Hansen<\/a>*<\/td>\nBU-Biology, CRC<\/td>\nInvestigator<\/td>\n<\/tr>\n
Nawfal Istfan<\/i><\/a>*<\/sup> <\/i><\/td>\nEndocrinology, <\/i>Diabetes & Nutrition BUSM<\/i><\/td>\nInvestigator<\/td>\n<\/tr>\n
Kostya Kandror<\/i><\/a><\/td>\nBiochemistry, BUSM<\/td>\nInvestigator<\/td>\n<\/tr>\n
Simon Kasif<\/td>\nBioinformatics, CRC<\/td>\nInvestigator<\/td>\n<\/tr>\n
Igor Kramnik<\/a><\/td>\nImmunology, BUSM<\/td>\nInvestigator<\/td>\n<\/tr>\n
Matt Layne<\/a><\/td>\nBiochemistry, BUSM<\/td>\nInvestigator<\/td>\n<\/tr>\n
Mi-Jeong Lee*<\/i><\/td>\nMedicine, Endocrinology, Diabetes & Nutrition BUSM<\/td>\nInvestigator<\/td>\n<\/tr>\n
Karen K. Miller<\/td>\nEndocrinology, MGH<\/td>\nCollaborator<\/td>\n<\/tr>\n
Barbara Nikolajczyk<\/td>\nMedicine, Microbiology, BUSM<\/td>\nInvestigator<\/td>\n<\/tr>\n
Valentina Perissi<\/a><\/td>\nBiochemistry, BUSM<\/td>\nInvestigator<\/td>\n<\/tr>\n
Vishwajeet Puri*<\/i><\/td>\nMedicine, Endocrinology, Diabetes & Nutrition BUSM<\/td>\nInvestigator<\/td>\n<\/tr>\n
Barbara Schreiber<\/a><\/td>\nBiochemistry, BUSM<\/td>\nInvestigator<\/td>\n<\/tr>\n
Steven Smith*<\/i><\/td>\nBurnham Inst, Florida Hospital<\/td>\nCollaborator<\/td>\n<\/tr>\n
David Waxman<\/a><\/td>\nCell and Molecular Biology, BU-CRC<\/td>\nInvestigator<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

MAIN ARC PROJECT(S) FOR 2009-2010:<\/strong><\/strong><\/h3>\n

Our group has decided to pursue three objectives that we envision will serve as a new platform to produce preliminary data and evidence of collaborations for planned PPGs.<\/p>\n

1. Establish and utilize a mouse model (fat transplantation) to determine cell autonomous sex-related differences in adipocyte and adipose tissue biology with a focus on mechanisms underlying the protection of females from adipose tissue inflammation\/remodeling events.<\/p>\n

2. Identify sex-biased and depot-specific differences in gene expression networks that are common in mouse and human (bioinformatic analysis of existing and emerging datasets).<\/p>\n

3. Establish phenotypic characteristics (growth, differentiation) of preadipocytes (adipose stem cells) culture of male and female-derived adipocytes from human adipose depots, and their morphology. Plans for year 2-3 will analyze the metabolic effects of human adipose tissue or preadipocytes of different depot and Mvs. F origin when transplanted into immune-compromised rodents.<\/p>\n

ARC AS A RESOURCE:<\/strong><\/h3>\n

-Microarray results from visceral adipose tissues of male and female mice and humans<\/p>\n

-Adipose Tissues,\u00a0 preadipocyte or other stromal-derived cultures, and their products (e.g conditioned media) from male and female mice and humans<\/p>\n

AIM:\u00a0 We plan seminars and activities, co-sponsored by BNORC, to foster the translation of basic research in adipose tissue biology and obesity using cell and mouse models.\u00a0 We focus on topics that bring together multiple ARCs.<\/p>\n

–\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 The Annual Program of BNORC will focus on Nutrition, obesity and the microbiome, a topic of keen interest to the Bariatric ARC as well as ours.<\/p>\n

–\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 We will also continue seminars around the interface of CVD, Insulin resistance and Obesity in men and women that was highlighted in our recent symposium on Brain Control of Sympathetic Function and Cardiovascular Function.<\/p>\n

–\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Browning, britening, and whitening of adipocytes. This topic involves active collaborations with the MitoARC.<\/p>\n

Our central goal is to bring together researchers on the BUMC and BU to accelerate conversations on topics related to obesity and related disease.\u00a0 The goal is innovative integrative collaborations to address this very difficult to study disease at basic and translational levels.<\/p>\n

Pictures, Images, Figures:<\/strong><\/h3>\n
\"Venn
Venn diagram illustrating sex and depot-dependent difference in gene expression in adipose tissues (gonadal fat (GF) and inguinal subcutaneous fat (IF) of mice fed a high fat diet to induced obesity. Note that relatively few of the genes that are differentially expressed are common to both depots. (Clegg, Grove, Fried, Greenberg, et al., IJO In press)<\/figcaption><\/figure>\n
\"Gonadal
Gonadal steroids like contribute to sex differences in fat distribution in males and females through epigenetic effects and direct actions on adipose tissue growth, inflammation, metabolic and endocrine functions.<\/figcaption><\/figure>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

INITIATION DATE: 12.01.09 ARC DIRECTORS AND CO-DIRECTORS: Susan K. Fried, PhD; Director; Professor; Medicine\/ Endocrinology Paul Pilch, PhD; Co-Director; Professor; Biochemistry OVERVIEW OF GOALS AND MISSION: Abstract The ARC focuses on the role of adipose tissue biology in the metabolic complications of obesity in men and women.\u00a0 Our members have complementary expertise in biochemistry, cell […]<\/p>\n","protected":false},"author":2921,"featured_media":0,"parent":4379,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/pages\/340"}],"collection":[{"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/users\/2921"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/comments?post=340"}],"version-history":[{"count":38,"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/pages\/340\/revisions"}],"predecessor-version":[{"id":3543,"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/pages\/340\/revisions\/3543"}],"up":[{"embeddable":true,"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/pages\/4379"}],"wp:attachment":[{"href":"https:\/\/www.bumc.bu.edu\/evanscenteribr\/wp-json\/wp\/v2\/media?parent=340"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}